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  4. Recombinant Mouse Lysine-specific histone demethylase 1B (Kdm1b), partial

Recombinant Mouse Lysine-specific histone demethylase 1B (Kdm1b), partial

  • 中文名称：
    小鼠Kdm1b重组蛋白
  • 货号：
    CSB-YP815880MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kdm1b重组蛋白
  • 货号：
    CSB-EP815880MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kdm1b重组蛋白
  • 货号：
    CSB-EP815880MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kdm1b重组蛋白
  • 货号：
    CSB-BP815880MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kdm1b重组蛋白
  • 货号：
    CSB-MP815880MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm1b
  • Uniprot No.：
    Q8CIG3
  • 别名：
    Kdm1b; Aof1; Lsd2; Lysine-specific histone demethylase 1B; EC 1.-.-.-; Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
  • 基因功能参考文献：
    1. reveal a direct role of hypoxia-inducible factor in regulating miRNA biogenesis and consequently activating the miR-215-KDM1B-mediated signaling required for glioma-initiating cells adaptation to hypoxia PMID: 26766590
    2. AOF1 is the second histone demethylase in the family of flavin-dependent amine oxidases and reveals a demethylase-independent repression function. PMID: 20101264
    3. oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to set up the DNA methylation marks at four out of seven imprinted genes examined PMID: 19727073
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 组织特异性：
    Expressed in growing oocytes and in intestinal gland.
  • 数据库链接：

    KEGG: mmu:218214

    STRING: 10090.ENSMUSP00000038373

    UniGene: Mm.31259

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