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  4. Recombinant Mouse Lysine-specific demethylase 4B (Kdm4b), partial

Recombinant Mouse Lysine-specific demethylase 4B (Kdm4b), partial

  • 中文名称：
    小鼠Kdm4b重组蛋白
  • 货号：
    CSB-YP838678MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kdm4b重组蛋白
  • 货号：
    CSB-EP838678MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kdm4b重组蛋白
  • 货号：
    CSB-EP838678MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kdm4b重组蛋白
  • 货号：
    CSB-BP838678MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kdm4b重组蛋白
  • 货号：
    CSB-MP838678MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm4b
  • Uniprot No.：
    Q91VY5
  • 别名：
    Kdm4b; Jhdm3b; Jmjd2b; Lysine-specific demethylase 4B; EC 1.14.11.-; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能参考文献：
    1. Jmjd2b deletion in adipose tissues induced obesity and systemic metabolic abnormalities. PMID: 30073721
    2. Data show that lysine demethylase 4 A/B double tudor domains (KDM4A/B DTDs) bind strongly to histone H3 (H3)K23me3. PMID: 27841353
    3. results indicate that JMJD2B regulates PPARgamma and C/EBPalpha during adipogenesis PMID: 28060835
    4. JMJD2B-deficient mice exhibited hyperactive behavior, sustained hyperactivity in a novel environment, deficits in working memory and spontaneous epileptic-like seizures. PMID: 27023172
    5. KDM4B histone demethylase regulates expression of myogenic regulators such as MyoD and thereby controls myogenic differentiation of C2C12 myoblast cells. PMID: 25534856
    6. This study establishes novel Jmjd2b targets that potentiate a biological rationale involving Jmjd2b in NSC inflammation. PMID: 22890720
    7. The promoter of Kdm4b is bound and activated by C/EBPbeta PMID: 22722334
    8. Induction of Jmjd2b in the embryonic stem cells decreased total levels of histone-3 lysine-9 trimethylation (H3K9me3) by 63%. PMID: 23263990
    9. Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia. PMID: 22951486
    10. A subgroup of murine Jmjd2 proteins antagonize H3K9me3 at pericentric heterochromatin. PMID: 16738407

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM3 histone demethylase family
  • 数据库链接：

    KEGG: mmu:193796

    STRING: 10090.ENSMUSP00000025036

    UniGene: Mm.45047

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