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  4. Recombinant Mouse Lysine-specific demethylase 3A (Kdm3a), partial

Recombinant Mouse Lysine-specific demethylase 3A (Kdm3a), partial

  • 中文名称：
    小鼠Kdm3a重组蛋白
  • 货号：
    CSB-YP750852MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kdm3a重组蛋白
  • 货号：
    CSB-EP750852MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kdm3a重组蛋白
  • 货号：
    CSB-EP750852MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kdm3a重组蛋白
  • 货号：
    CSB-BP750852MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kdm3a重组蛋白
  • 货号：
    CSB-MP750852MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kdm3a
  • Uniprot No.：
    Q6PCM1
  • 别名：
    Kdm3a; Jhdm2a; Jmjd1a; Kiaa0742Lysine-specific demethylase 3A; EC 1.14.11.-; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
  • 基因功能参考文献：
    1. Data suggest a critical role for KDM3A in the PI3K/AP-1 oncogenic axis and propose a novel strategy for inhibition of KDM3A against liver tumor development under PI3K pathway activation. PMID: 28692045
    2. JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1) and downstream targets including Ucp1 in brown adipocytes. PMID: 25948511
    3. Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which in turn display altered fractionation of beta-actin and gamma-tubulin. PMID: 24554764
    4. Results show that Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor. PMID: 25071150
    5. Despite these differences in rats, genetic knockout of Kdm3a in mice resulted in no dramatic effect on immune system development and activation or EAE susceptibility and severity PMID: 24312603
    6. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination. PMID: 24009392
    7. Exposing cells to either chemical or cellular sources of (*)NO resulted in a significant increase in dimethyl Lys-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A. PMID: 23546878
    8. essential for spermatogenesis and plays a role in regulating fat metabolic gene expression in muscle and brown fat tissue PMID: 19875498
    9. the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem-regulated gene expression and spermatogenesis PMID: 19910458
    10. TSGA may modulate the function of ER71 and thereby affect spermatogenesis as well as embryonic development PMID: 16619273
    11. Jmjd1a might be a critical signaling molecule underlying the maintenance of pluripotency in mouse embryonic stem cells PMID: 16988490
    12. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes. PMID: 17938240
    13. the mouse H3K9me2/1-specific demethylase JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) is essential for spermatogenesis PMID: 17943087
    14. Jmjd1a coregulates myocardin-related transcription factor-A (MRTF-A) and myocardin-dependent transcription. PMID: 17991879
    15. G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells PMID: 18535151
    16. Jhdm2a expression is induced by beta-adrenergic stimulation, and that Jhdm2a directly regulates peroxisome proliferator-activated receptor alpha (Ppara) and Ucp1 expression PMID: 19194461
    17. Thus, H3K9 demethylase JHDM2a is a crucial regulator of genes involved in energy expenditure and fat storage, which suggests it is a previously unrecognized key regulator of obesity and metabolic syndrome. PMID: 19624751

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa.
  • 蛋白家族：
    JHDM2 histone demethylase family
  • 组织特异性：
    Highly expressed in testis (at protein level). Also expressed at high levels in tissues responsive to sympathetic nerve activity such as brown adipose tissue and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:104263

    STRING: 10090.ENSMUSP00000065716

    UniGene: Mm.260479

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