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  4. Recombinant Mouse Lymphocyte-specific helicase (Hells), partial

Recombinant Mouse Lymphocyte-specific helicase (Hells), partial

  • 中文名称：
    小鼠Hells重组蛋白
  • 货号：
    CSB-YP733715MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hells重组蛋白
  • 货号：
    CSB-EP733715MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hells重组蛋白
  • 货号：
    CSB-EP733715MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hells重组蛋白
  • 货号：
    CSB-BP733715MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hells重组蛋白
  • 货号：
    CSB-MP733715MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hells
  • Uniprot No.：
    Q60848
  • 别名：
    Hells; Lsh; Pasg; Lymphocyte-specific helicase; EC 3.6.4.-; Proliferation-associated SNF2-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
  • 基因功能参考文献：
    1. Lsh assists epigenetic gene repression upon binding to the Oct4 promoter region. PMID: 28621576
    2. These results suggest that Lsh exerts epigenetic regulation at key regulators of neural stem cell fate ensuring adequate neural stem/progenitor cells self-renewal and maintenance during development. PMID: 28442710
    3. fibroblasts derived from chromatin remodeling ATPase LSH (HELLS)-null mouse embryos, which lack DNA methylation from centromeric repeats, transposons and a number of gene promoters, are capable of reestablishing DNA methylation and silencing of misregulated genes upon re-expression of LSH. PMID: 27179028
    4. Data suggest that HELLS controls cytosine methylation in a nuclear compartment that is in part defined by lamin B1 attachment regions. PMID: 25170028
    5. histone H3 lysine 4 methylation modification was assessed in murine embryonic fibroblasts (MEFs) derived from the DNA methylation mutant Lsh(-/-) mice. PMID: 24711395
    6. These results indicate that in the absence of HELLS, proliferation of spermatogonia is reduced and germ cell differentiation arrested at the midpachytene stage, implicating an essential role for HELLS during male meiosis. PMID: 21349825
    7. LSH is essential for developmentally programmed de novo DNA methylation at the promoters of protein coding genes and recruitment of G9a/GLP complex to a subset of genomic loci. PMID: 21149390
    8. Data show that hypomethylation in Lsh-/- cells is associated with efficient transcriptional elongation and splicing. PMID: 20161795
    9. model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns PMID: 14612388
    10. PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death. PMID: 15105378
    11. Lsh has a critical and previously unidentified role in epigenetic gene silencing and maintenance of genomic stability during female meiosis. PMID: 17115026
    12. Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of polycomb repressive complex targets PMID: 17726103
    13. DNA hypomethylation caused by Lsh depletion is linked to transcriptional upregulation of retroviral elements and oncogenes such as PU.1 which in turn may promote the development of erythroleukemia in mice PMID: 18487951

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  • 亚细胞定位：
    Nucleus. Note=Closely associated with pericentric heterochromatin.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 组织特异性：
    Highly expressed in thymus, bone marrow, and testis. Not detected in heart, brain, liver, kidney, skeletal muscle, spleen, peripheral blood lymphocytes, small intestine, colon, prostate or ovary.
  • 数据库链接：

    KEGG: mmu:15201

    STRING: 10090.ENSMUSP00000025965

    UniGene: Mm.392920

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