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  4. Recombinant Mouse Lymphocyte antigen 86 (Ly86)

Recombinant Mouse Lymphocyte antigen 86 (Ly86)

  • 中文名称：
    小鼠Ly86重组蛋白
  • 货号：
    CSB-YP013252MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ly86重组蛋白
  • 货号：
    CSB-EP013252MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ly86重组蛋白
  • 货号：
    CSB-EP013252MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ly86重组蛋白
  • 货号：
    CSB-BP013252MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ly86重组蛋白
  • 货号：
    CSB-MP013252MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ly86
  • Uniprot No.：
    O88188
  • 别名：
    Ly86; Md1Lymphocyte antigen 86; Ly-86; Protein MD-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-162
  • 氨基酸序列
    D HGSENGWPKH TACNSGGLEV VYQSCDPLQD FGLSIDQCSK QIQSNLNIRF GIILRQDIRK LFLDITLMAK GSSILNYSYP LCEEDQPKFS FCGRRKGEQI YYAGPVNNPG LDVPQGEYQL LLELYNENRA TVACANATVT SS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
  • 基因功能参考文献：
    1. Cardiac-specific overexpression of MD-1 significantly attenuated pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction, whereas loss of MD-1 had the opposite effects. PMID: 28165494
    2. results suggest that soluble MD-1 is a valuable biomarker for inflammatory diseases PMID: 27352793
    3. our results reveal that MD-1 deficiency is of critical importance in down-regulating induction and progression of colitis, thereby suggesting that MD-1 might be a target for future interventional therapies of inflammatory bowel disease. PMID: 27209086
    4. Heat-inactivated murine serum diminished the ability of sMD-1 to bind RP105. PMID: 22118968
    5. Together with the binding assay with tetra-acylated lipid IVa, MD-1 is shown to be a lipid-binding coreceptor. PMID: 20595044
    6. Required for cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide . RP105/MD-1 has structural similarity to Toll-like receptor 4(TRL4) PMID: 11861286
    7. Regulation of MD-1 expression may control both pregnancy and allograft survival PMID: 12322892
    8. direct LPS interaction with cell surface TLR4-MD-2 that is distinct from that with MD-2 or CD14. PMID: 14517279
    9. A signal via the RP105/MD-1 complex drves B cells to differentiate into antibody-secreting cells. PMID: 15905547

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  • 亚细胞定位：
    Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
  • 组织特异性：
    Highly expressed in spleen, liver, brain and thymus, and at lower levels in kidney.
  • 数据库链接：

    KEGG: mmu:17084

    STRING: 10090.ENSMUSP00000021860

    UniGene: Mm.2639

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