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  4. Recombinant Mouse Low-density lipoprotein receptor-related protein 8 (Lrp8), partial

Recombinant Mouse Low-density lipoprotein receptor-related protein 8 (Lrp8), partial

  • 中文名称：
    小鼠Lrp8重组蛋白
  • 货号：
    CSB-YP849758MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lrp8重组蛋白
  • 货号：
    CSB-EP849758MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lrp8重组蛋白
  • 货号：
    CSB-EP849758MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lrp8重组蛋白
  • 货号：
    CSB-BP849758MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lrp8重组蛋白
  • 货号：
    CSB-MP849758MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lrp8
  • Uniprot No.：
    Q924X6
  • 别名：
    Lrp8; Apoer2; Low-density lipoprotein receptor-related protein 8; LRP-8; Apolipoprotein E receptor 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2. Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells.
  • 基因功能参考文献：
    1. The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia. PMID: 30066942
    2. Stage-specific labeling of newborn Apoer2-deficient neurons revealed that the neurons ectopically invaded the marginal zone and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners. PMID: 27909010
    3. GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse. PMID: 28978486
    4. A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension PMID: 26990752
    5. findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1 PMID: 27810638
    6. reveals a novel function for Reelin/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration PMID: 26386179
    7. total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn PMID: 25340851
    8. This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. PMID: 25308109
    9. This study demonistrated that LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice. PMID: 25892301
    10. Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP, and cued fear learning. PMID: 25429077
    11. genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function. PMID: 25197062
    12. Tandem Sepp1-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them. PMID: 24760755
    13. data demonstrate that several multivalent ligands for ApoER2 induce clustering in transfected cells and primary neurons and that these complexes included other synaptic molecules, such as APP and PSD-95 PMID: 24755222
    14. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis. PMID: 24840660
    15. longer isoforms of Sepp1 with high selenium content interact with a binding site distinct from the ligand-binding domain of apoER2 for selenium delivery PMID: 24532792
    16. Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. PMID: 24381170
    17. The Reelin receptors ApoER2 and VLDLr play essential roles in Reelin-mediated migration and positioning of mesencephalic dopaminergic neurons. PMID: 23976984
    18. Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons. PMID: 23506116
    19. there are reelin-independent functions of very-low-density lipoprotein receptor (VLDLR) and low-density lipoprotein receptor-related protein 8 in geniculate nucleus development. PMID: 23758727
    20. Data indicate that uptake of Sepp1 and Gpx3 by d-13 visceral yolk sac was independent of apoER2 and megalin. PMID: 23651543
    21. Data show identified ApoER2 as being the main receptor responsible for Reelin mediated detachment of neuroblasts and correct migration of early generated interneurons within the OB, a prerequisite for correct OB lamination. PMID: 23209795
    22. These results identify LRP8 as a novel positive factor of canonical Wnt signaling pathway. PMID: 22589174
    23. apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body. PMID: 22761431
    24. ApoEr2 plays important roles in structure and function of CNS synapses and dendritic spines PMID: 21347244
    25. activation of VLDLR and apoER2 by reelin and apoE induces ABCA1 expression and cholesterol efflux via a Dab1-PI3K-PKCzeta-Sp1 signaling cascade. PMID: 22170052
    26. ApoER2 plays a pivotal role in the development of the rod bipolar pathway and maintenance of retinal synaptic connectivity. PMID: 21976526
    27. Apolipoprotein E receptor-2 deficient transgenic mice fed a selenium-deficient diet become neurologically dysfunctional and do not survive. PMID: 17553992
    28. ApoER2 is involved in pathogenesis of antiphospholipids antibodies. PMID: 21119114
    29. Reelin activates the Rho GTPase Cdc42, known for its role in neuronal morphogenesis and directed migration, in an ApoER2-, Disabled-1-, and phosphatidylinositol 3-kinase-dependent manner. PMID: 21048135
    30. Data show that the identification of VLDLR and ApoER2 as Idol(Mylip) targets suggests potential roles for this LXR-inducible E3 ligase in the central nervous system in addition to lipid metabolism. PMID: 20427281
    31. One APOER2 isoform has 4 binding repeats & an adjacent short 13 AA insertion with a furin cleavage site. The resulting receptor fragment (the entire ligand-binding domain is secreted as soluble polypeptide) inhibits Reelin signaling in primary neurons. PMID: 12426372
    32. Reelin receptor machinery, including ApoER2 and VLDLR and Dab1 protein, is located in radial glia precursors in cortical wall from the ventricular zone to the pial surface. PMID: 12586425
    33. apoER2 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation PMID: 12695510
    34. Apolipoprotein E receptors activate p42/44 MAPK and have roles in neurite outgrowth PMID: 15169786
    35. Reelin treatment targets adaptor protein Disabled-1(Dab1) for proteolytic degradation by the ubiquitin-proteasome pathway and signaling through neuronal apolipoprotein E receptor 2 can activate the ubiquitin-proteasome machinery PMID: 15175346
    36. binding of LDL to platelets resulted in tyrosine phosphorylation of apoER2' PMID: 15459198
    37. Reelin binds several receptors. including LrpB ini cultured hippocampux neurons. PMID: 15987942
    38. Thus, alternative splicing of Apoer2, a novel component of the NMDA receptor complex, controls the modulation of NMDA receptor activity, synaptic neurotransmission, and memory by Reelin. PMID: 16102539
    39. ApoEr2 coprecipitated with APP alpha- and beta-CTF, and F-spondin reduced the levels of APP intracellular domain signaling. PMID: 16227578
    40. ApoEr2 can form a multiprotein complex with NMDA receptor subunits and PSD95 PMID: 16332682
    41. platelets adhere to dimeric beta2GPI under both arterial and venous shear stresses. Platelets adhere via two receptors: GPIbalpha and apoER2'. These receptors are present in a complex on the platelet surface PMID: 17096706
    42. Study demonstrates that a differentially spliced isoform of ApoE receptor 2 (Apoer2), is essential for protection against neuronal cell loss during normal aging. PMID: 17174920
    43. Sertoli cell ApoER2 is a Sepp1 receptor and a component of the selenium delivery pathway to spermatogenic cells PMID: 17314095
    44. These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin. PMID: 17494763
    45. ApoER2 knockout mice also displayed altered use of specific search strategies in the maze PMID: 17907841
    46. present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons PMID: 17913789
    47. the activity of PCSK9 and its binding affinity on VLDLR and ApoER2 does not depend on the presence of LDLR. PMID: 18039658
    48. Fyn, due in part to its effects on Dab1, regulates the phosphorylation, trafficking, and processing of APP and apoEr2. PMID: 18089558
    49. Neurodegeneration in mice resulting from loss of functional apolipoprotein E receptor 2. PMID: 18172410
    50. The plasticity associated with the Reelin-Apoer 2-exon 19 pathway is distinct from that which contributes to injury-induced enhancement of 'pain' processing. PMID: 18279306

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
  • 蛋白家族：
    LDLR family
  • 组织特异性：
    Expressed in neurons throughout the brain, with strong expression in pyramidal neurons of the hippocampus, granule cells of the dentate gyrus, cortical neurons and Purkinje cells of the cerebellum. Also expressed in the epithelium of the choroid plexus an
  • 数据库链接：

    UniGene: Mm.442134

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