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  4. Recombinant Mouse Low-density lipoprotein receptor-related protein 5 (Lrp5), partial

Recombinant Mouse Low-density lipoprotein receptor-related protein 5 (Lrp5), partial

  • 中文名称：
    小鼠Lrp5重组蛋白
  • 货号：
    CSB-YP842018MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lrp5重组蛋白
  • 货号：
    CSB-EP842018MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lrp5重组蛋白
  • 货号：
    CSB-EP842018MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lrp5重组蛋白
  • 货号：
    CSB-BP842018MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lrp5重组蛋白
  • 货号：
    CSB-MP842018MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lrp5
  • Uniprot No.：
    Q91VN0
  • 别名：
    Lrp5; Lr3; Lrp7; Low-density lipoprotein receptor-related protein 5; LRP-5; Low-density lipoprotein receptor-related protein 7; LRP-7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development. Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis.
  • 基因功能参考文献：
    1. Heterozygous deletion of the LRP5 gene in mice could alter the profile of the immune cells, influence the balance of immune environment, and modulate bone homeostasis. PMID: 29899194
    2. Megakaryocytes are increased in the bone marrow of Lrp5G170V/G170V mice. Depletion of megakaryocytes does not affect the Lrp5-induced high bone mass. PMID: 29454962
    3. The phenotype of the Lrp5(tvrm111B) mutant includes abnormalities of the retinal vasculature and of bone mineral density. PMID: 28356706
    4. the LRP5 mutation in high bone mass transgenic mice shows altered bone matrix composition PMID: 27230741
    5. Lrp6 is the key mediator of Wnt3a signaling in osteoblasts and Lrp5 played a less significant role in mediating Wnt3a signaling. PMID: 29176883
    6. Identification of a link between Wnt-Lrp5 signaling and insulin signaling in the osteoblast that has the potential to influence energy balance and compound the detrimental effects of a HFD on whole-body metabolism. PMID: 28938444
    7. Lrp5(-/-) mice displayed significantly delayed retinal vascular development, absence of deep layer retinal vessels, leading to increased levels of vascular endothelial growth factor and subsequent pathologic glomeruloid vessels, as well as decreased inner retinal visual function. PMID: 27524797
    8. A mouse LRP5 ectodomain recombinant was cleaved by VAP1, creating a peptide, VAHLTGIHAVEE, detected by mass spectrometric analysis of the 140-kDa fragment, suggesting that the sessile bond by VAP1 is Glu1206-Val1207. PMID: 28425175
    9. we revealed miR-375-3p negatively regulated osteogenesis by targeting LRP5 and beta-catenin PMID: 28158288
    10. lung myeloid cells are responsive to Lrp5/beta-catenin signaling, leading to differentiation of an alveolar macrophage subtype that antagonizes the resolution of lung fibrosis. PMID: 27668462
    11. LRP5 is a novel anti-inflammatory macrophage marker that positively regulates migration, phagocytosis, lipid uptake and metabolism. PMID: 26739212
    12. These results revealed a new role of the canonical Lrp5/6-beta-catenin pathway in regulating the morphogenesis of the cerebellum during postnatal development. PMID: 26772978
    13. LRP5 function in mice causes retinal hypovascularization during development as well as retinal neovascularization in adulthood with disorganized and leaky vessels. PMID: 27031698
    14. Lrp5 is required for glucose uptake, and glucose uptake regulates the growth rate of mammary epithelial cells in culture. PMID: 26711269
    15. Data show that LDL receptor-related protein 5 (LRP5) gain-of-function mutations do not activate beta-catenin signaling in osteoblasts. PMID: 26681532
    16. These in vivo data support in vitro studies regarding the mechanism of HBM-causing mutations, and imply that HBM LRP5 receptors differ in their relative sensitivity to inhibition by SOST and DKK1. PMID: 25808845
    17. Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results frommechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse models. PMID: 26554834
    18. In hypercholesterolemia LRP5(-/-) mice Wnt/beta-catenin pathway was shut down. An antiatherogenic role for LRP5 was demonstrated as HC LRP5(-/-) mice developed larger aortic atherosclerotic lesions than WT mice. PMID: 25748163
    19. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5/Tie2 pathway. PMID: 26091161
    20. Data show that low density lipoprotein receptor-related protein 5 (LRP5) and the canonical Wnt pathway down-regulation regulate the dyslipidaemic profile by promoting lipid and macrophage retention in the vessel wall. PMID: 25656427
    21. Lrp5 binds to Frizzled, preventing Frz-regulated non-canonical Wnt pathway activation and further non-canonical pathway-mediated tumour metastasis. PMID: 25902418
    22. Sclerostin inhibits bone formation through Lrp5 interaction. PMID: 25640331
    23. Our findings indicate that LRP5 plays an essential role in osteoarthritis cartilage destruction PMID: 24479426
    24. Wnt-Lrp5 signaling regulates basic cellular activities. PMID: 25802278
    25. Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling. PMID: 24789067
    26. Col1a2(+/p.G610C) ;Lrp5(+/p.A214V) offspring had significantly increased bone mass and strength compared to Col1a2(+/p.G610C) ;Lrp5(+/+) littermates. PMID: 24677211
    27. Bone formation was more reduced in Col1a1-Krm2 than in Lrp5-/- mice, whereas osteoclast number was similarly increased in both genotypes in comparison with wild-type mice PMID: 25061805
    28. Hgf as an important transactivator of canonical Wnt signaling that is mediated by Met-stimulated, Gsk3-dependent Lrp5/6 phosphorylation PMID: 24692544
    29. Knockdown of LRP5 expression by siRNA prevents tissue plasminogen activator (tPA)-induced neurite extension. PMID: 23925701
    30. LRP5 signaling is a prerequisite for neovascularization in VLDLR knockout mice. LRP5 may be an effective target for inhibiting intraretinal neovascularization. PMID: 24058663
    31. The Wnt coreceptor, Lrp5, is a genetic driver of lung fibrosis in mice and a marker of disease progression and severity in humans with idiopathic pulmonary fibrosis. PMID: 24921217
    32. The current study is the first to reveal that dioscin can promote osteoblasts proliferation and differentiation via Lrp5 and ER pathway. PMID: 24742230
    33. In the absence of LRP5, the anabolic effects of SOST depletion can occur via other receptors (such as LRP4/6) PMID: 24225945
    34. Lack of LRP5 has a more pronounced effect on gene expression than the high bone mass-causing LRP5 missense mutation. PMID: 23553928
    35. tissue stiffness modulated by the extracellular matrix cross-linking enzyme, lysyl oxidase, regulates postnatal lung development through LRP5-Tie2 signaling PMID: 23841513
    36. These results indicate that expression of both Lrp5 and Lrp6 are required within mature osteoblasts for normal postnatal bone development. PMID: 23675479
    37. Lrp5-mediated Wnt signaling significantly contributes to maintenance of mechanical properties and bone mass. PMID: 23356985
    38. LRP5-Tie2-Ang signaling axis plays a central role in control of both angiogenesis and alveolarization during postnatal lung development PMID: 22848540
    39. Results show that loss of function of Lrp5 increases cartilage degradation in mild instability-induced OA models in mice PMID: 22850184
    40. Peptide-mediated disruption of N-cadherin-LRP5/6 interaction increases Wnt/beta-catenin signaling and osteoblast function in vitro and promotes calvaria bone formation in vivo. PMID: 22576936
    41. The importance of Lrp5 in bone cell mechanotransduction, is reported. PMID: 22750014
    42. study hypothesizes that calcific aortic valve disease develops secondary to Wnt3a/Lrp5 activation via oxidative-mechanical stress in eNOS null mice PMID: 22359381
    43. Data suggest that Lrp5 loss and gain of function mutations result in cell-autonomous alterations in osteoblast proliferation and apoptosis but do not alter the proliferative response of osteoblasts to mechanical strain in vitro. PMID: 22567110
    44. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. PMID: 22433869
    45. Lrp5 and Lrp6 play redundant roles in intestinal epithelium development, and that Lrp5/6 might regulate intestinal stem/precursor cell maintenance by regulating Wnt/beta-catenin signaling. PMID: 21866564
    46. Data suggest that Lrp5 regulates multiple groups of genes that influence retinal angiogenesis and may contribute to the pathogenesis of familial exudative vitreoretinopathy (FEVR). PMID: 22272305
    47. Insulin signaling also involves the Wnt co-receptor LRP5, which has a positive effect on insulin signaling. PMID: 22337886
    48. Lrp5/6 is necessary for calcification in the aortic valve in the presence of experimental hypercholesterolemia. PMID: 21678468
    49. Data indicate an important role for mesenchymal Lrp5/6 signaling in limb patterning. PMID: 21924256
    50. These studies uncover a new and important molecular tuning mechanism for differential regulation of LRP5 and LRP6 phosphorylation and signaling activity. PMID: 21887268

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Endoplasmic reticulum.
  • 蛋白家族：
    LDLR family
  • 组织特异性：
    Widely expressed, with the highest expression levels in liver, heart, and lung and the lowest levels in brain and spleen.
  • 数据库链接：

    KEGG: mmu:16973

    STRING: 10090.ENSMUSP00000025856

    UniGene: Mm.274581

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