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  4. Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial (Acadl)

Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial (Acadl)

  • 中文名称：
    Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial(Acadl)
  • 货号：
    CSB-YP001125MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial(Acadl)
  • 货号：
    CSB-EP001125MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial(Acadl)
  • 货号：
    CSB-EP001125MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial(Acadl)
  • 货号：
    CSB-BP001125MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Long-chain specific acyl-CoA dehydrogenase, mitochondrial(Acadl)
  • 货号：
    CSB-MP001125MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Acadl
  • Uniprot No.：
    P51174
  • 别名：
    AcadlLong-chain specific acyl-CoA dehydrogenase; mitochondrial; LCAD; EC 1.3.8.8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    31-430
  • 氨基酸序列
    GAEARLETPS AKKLTDVGIR RIFSSEHDIF RESVRKFFQE EVIPHHTEWE KAGEVSREVW EKAGKQGLLG INIAEKHGGI GGDLLSTAVT WEEQAYSNCT GPGFSLHSDI VMPYIANYGT KEQIEKFIPQ MTAGKCIGAI AMTEPGAGSD LQGVRTNAKR SGSDWILNGS KVFITNGWLS DLVIVVAVTN REARSPAHGI SLFLVENGMK GFIKGRKLHK MGMKAQDTAE LFFEDVRLPA NALLGEENKG FYYLMQELPQ ERLLIAELAI SACEFMFEET RNYVKQRKAF GKTVAHIQTV QHKLAELKTH ICVTRAFVDS CLQLHETKRL DSGSASMAKY WASELQNSVA YECVQLHGGW GYMWEYPIAK AYVDARVQPI YGGTNEIMKE LIARQIVSDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.
  • 基因功能参考文献：
    1. LCAD-/- mice succumb to influenza from bioenergetic starvation, likely due to increased reliance upon glucose for energy. PMID: 29458021
    2. SIRT3 may play an essential role in attenuating lipid accumulation in the heart through the deacetylation of LCAD PMID: 25748450
    3. Carnitine supplementation lowered myocardial triglycerides, normalizing myocardial triglycerides levels in LCAD Knock-out mice. PMID: 23563854
    4. LCAD KO mice are ineffective in maintaining metabolic homeostasis during fasting, which is reflected by an impaired myocardial energy status in fasted LCAD KO mice. PMID: 24042017
    5. the fatty acid oxidation pathway and LCAD are factors contributing to the pathophysiology of pulmonary disease PMID: 24591516
    6. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. PMID: 24121500
    7. mice with an inherited deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD), were protected from high-fat diet-induced obesity and liver and muscle insulin resistance. PMID: 20444420
    8. LCAD is deacetylated in wild-type mice under fasted conditions and by SIRT3 in vitro and in vivo; hyperacetylation of LCAD reduces its enzymatic activity PMID: 20203611
    9. These data demonstrate that primary defects in mitochondrial fatty acid oxidation capacity can lead to diacylglycerol accumulation, PKCepsilon activation, and hepatic insulin resistance. PMID: 17940018
    10. Novel candidate genes in T1D CD55 and Acadl were identified. PMID: 18178847
    11. substantial cardiac hypertrophy in LCAD-deficient mice PMID: 19736549

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Acyl-CoA dehydrogenase family
  • 组织特异性：
    Expressed in heart, skeletal muscle, kidney, and brain. Expressed in liver (at protein level).
  • 数据库链接：

    KEGG: mmu:11363

    STRING: 10090.ENSMUSP00000027153

    UniGene: Mm.2445

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