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  4. Recombinant Mouse Lithostathine-2 (Reg2)

Recombinant Mouse Lithostathine-2 (Reg2)

  • 中文名称：
    小鼠Reg2重组蛋白
  • 货号：
    CSB-YP600523MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Reg2重组蛋白
  • 货号：
    CSB-EP600523MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Reg2重组蛋白
  • 货号：
    CSB-EP600523MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Reg2重组蛋白
  • 货号：
    CSB-BP600523MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Reg2重组蛋白
  • 货号：
    CSB-MP600523MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Reg2
  • Uniprot No.：
    Q08731
  • 别名：
    Reg2; Lithostathine-2; Islet of Langerhans regenerating protein 2; REG-2; Pancreatic stone protein 2; PSP; Pancreatic thread protein 2; PTP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-173
  • 氨基酸序列
    QVAEEDFP LAEKDLPSAK INCPEGANAY GSYCYYLIED RLTWGEADLF CQNMNAGHLV SILSQAESNF VASLVKESGT TASNVWTGLH DPKSNRRWHW SSGSLFLFKS WATGAPSTAN RGYCVSLTSN TAYKKWKDEN CEAQYSFVCK FRA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Might act as an inhibitor of spontaneous calcium carbonate precipitation.
  • 基因功能参考文献：
    1. Normal expression of Reg2 gene is required for appropriate compensations in pancreatic islet proliferation and expansion in response to obesity and aging. PMID: 28009527
    2. mReg2 inhibits AIF-mediated apoptosis by promoting the nuclear presence of Scythe and inducing hsp70. PMID: 25370781
    3. Reg2 induces glucose-regulated peptide 78 (GRP78) expression via the Akt-mTORC1 axis. PMID: 24801175
    4. Reg2 protects MIN6 cells from streptozotocin-induced apoptosis by attenuating streptozotocin's ability to disrupt mitochondrial membrane integrity, activate caspase-3 and promote poly-ADP ribose polymerase cleavage, and induce apoptosis. PMID: 20919961
    5. adjuvant immunotherapy regulates type 1 diabetes in diabetic mice and induces Reg2-mediated regeneration of beta cells PMID: 20876350
    6. Overexpression of Reg2 gene offered no protection against streptozotocin-induced beta-cell damage and diabetes and did not protect acinar cells against caerulein-induced acute pancreatitis. PMID: 20489047
    7. Reg2 deficiency enhanced liver sensitivity to Fas-induced oxidative stress and delayed liver regeneration with persistent TNF-alpha/IL6/STAT3 signaling. PMID: 17133485
    8. RegII is a novel beta-cell-derived autoantigen in NOD mice. The autoimmune response against this protein may convert a regenerative into an islet-destructive process accelerating development of type 1 diabetes. [regII protein] PMID: 17192462
    9. Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and phosphorylation PMID: 17898082

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed only in regenerating islets and normal exocrine pancreas, but not in normal pancreatic islets. Expressed strongly in pancreas, weakly in liver, but not at all in gall bladder.
  • 数据库链接：

    KEGG: mmu:19693

    STRING: 10090.ENSMUSP00000023906

    UniGene: Mm.46360

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