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  4. Recombinant Mouse Leucine-rich repeat-containing protein 10 (Lrrc10)

Recombinant Mouse Leucine-rich repeat-containing protein 10 (Lrrc10)

  • 中文名称：
    小鼠Lrrc10重组蛋白
  • 货号：
    CSB-YP818351MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lrrc10重组蛋白
  • 货号：
    CSB-EP818351MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lrrc10重组蛋白
  • 货号：
    CSB-EP818351MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lrrc10重组蛋白
  • 货号：
    CSB-BP818351MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lrrc10重组蛋白
  • 货号：
    CSB-MP818351MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lrrc10
  • Uniprot No.：
    Q8K3W2
  • 别名：
    Lrrc10; HrlrrpLeucine-rich repeat-containing protein 10; Heart-restricted leucine-rich repeat protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-274
  • 氨基酸序列
    MGNTIRAFVA FIPTDRCQSY VVGDLREMPL DRMVDLSGSQ LRRFPLHVCS FTELVKLYLS DNHLHSLPPD LAQLQNLQIL ALDFNNFKAL PRVVCTLKQL CILYLGNNKL CDLPDELSLL QNLRTLWLES NCLTRLPDVV CELSLLKTLH AGSNALRLLP GQLRRLRELR TIWLSGNQLA DFPSVLLRMP FLEVIDVDRN SIRYFPSLAH LTNLKLVIYD HNPCRNAPKV GKGVRRVGRW AEETPEPDPR KARRYALAKE ENQEPPPPLL PSSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play important roles in cardiac development and/or cardiac function.
  • 基因功能参考文献：
    1. LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10 PMID: 26608339
    2. Data demonstrate that the transcription factors Nkx2-5 and GATA4 cooperatively regulate cardiac-specific expression of Lrrc10. PMID: 23751912
    3. Lrrc10 is a novel dilated cardiomyopathy candidate gene and the Lrrc10-/- mouse model is a unique system to investigate pediatric cardiomyopathy. PMID: 23236519
    4. GATA4 and MEF2C can both increase transcriptional activity of Lrrc10 promoter but that they do not work together in a synergistic fashion. PMID: 21345312
    5. SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates PMID: 15830381
    6. LRRC10 exhibits dynamic intracellular expression patterns in cardiomyocytes. PMID: 17626279
    7. Lrrc10-null mice develop normally and exhibit no discernable phenotype PMID: 18781631

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Detected specifically in the heart.
  • 数据库链接：

    KEGG: mmu:237560

    STRING: 10090.ENSMUSP00000073502

    UniGene: Mm.37320

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