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  4. Recombinant Mouse Leucine-rich repeat-containing G-protein coupled receptor 4 (Lgr4), partial

Recombinant Mouse Leucine-rich repeat-containing G-protein coupled receptor 4 (Lgr4), partial

  • 中文名称：
    小鼠Lgr4重组蛋白
  • 货号：
    CSB-YP012905MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lgr4重组蛋白
  • 货号：
    CSB-EP012905MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lgr4重组蛋白
  • 货号：
    CSB-EP012905MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lgr4重组蛋白
  • 货号：
    CSB-BP012905MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lgr4重组蛋白
  • 货号：
    CSB-MP012905MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lgr4
  • Uniprot No.：
    A2ARI4
  • 别名：
    Lgr4; Gpr48Leucine-rich repeat-containing G-protein coupled receptor 4; G-protein coupled receptor 48
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP.
  • 基因功能参考文献：
    1. he HA tag-specific antibody can be employed to characterize the biochemical features of Lgr4 and to identify possible biding partners of the protein in cells derived from various mouse tissues. PMID: 28634819
    2. LGR4 might play a vital role in stem cells from apical papillae proliferation and odontoblastic differentiation. PMID: 28986711
    3. compressive force induced the differentiation of RAW264.7 from increase in RANK and decrease in LGR4 expression. PMID: 29572179
    4. the host protein leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is essential for VSV and VSV-G pseudotyped lentivirus (VSVG-LV) to infect susceptible cells. PMID: 28842478
    5. Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation. PMID: 28768769
    6. LGR4 is another receptor for RANKL. LGR4 competes with RANK to bind RANKL and suppresses canonical RANK signaling during osteoclast differentiation. Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast number, surface area, and size) and increased bone erosion. PMID: 27064449
    7. Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/beta-catenin pathways. PMID: 27693558
    8. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration. PMID: 27088858
    9. These date indicate that hydrogen peroxide suppresses Lgr4 expression in osteoblastic cells. PMID: 27861872
    10. Lgr4 gene is regulated by BMP and is required for BMP effects on osteoblastic differentiation. PMID: 26332449
    11. Rspo1 and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt/beta-catenin signaling for bone formation. PMID: 28272338
    12. Study suggests that miR-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation. PMID: 28130056
    13. A mechanistic understanding of RANKL-LGR4 interaction has provided new insight into LGR4 mediated RANKL signaling in osteoporosis and other diseases PMID: 27178473
    14. LGR4 acted as a key receptor for Rspo2 to promote osteogenesis. PMID: 27140682
    15. Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 and Wnt/beta-catenin PMID: 26333992
    16. results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging. PMID: 25811370
    17. The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development. PMID: 25188337
    18. suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network PMID: 26102032
    19. An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity. PMID: 25063812
    20. formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt signaling pathway but not the TGF-beta/Smad pathway PMID: 24595031
    21. The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R-spondins. PMID: 24616052
    22. Lgr4 regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway. PMID: 24877628
    23. LGR4 plays an important role in the regulation of plasma lipid rhythms, partially through regulating the expression of microsomal triglyceride transfer protein; these data provide a possible link between the peripheral circadian clock and lipid metabolism PMID: 24353284
    24. data revealed the roles of Lgr4 in early prostate development and in stem cell differentiation through regulation of the Wnt, Notch, and Sonic Hedgehog signaling pathways. PMID: 23897697
    25. Lgr4KO and Lgr4/5KO results in complete loss of intestinal stem cells in embryos, impairs proliferation of developing kidney and skin epithelium, and depletes Lgr5+follicular epithelium and impairs hair follicle development. PMID: 24680895
    26. Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR syndrome PMID: 24519938
    27. Lgr4 activates Sox2 to regulate mammary development and stem cell functions via Wnt/beta-catenin/Lef1. PMID: 23712846
    28. identify the transforming growth factor beta antagonist follistatin as a key mediator of RSPO-LGR4 signaling in myogenic differentiation PMID: 24344199
    29. LGR4 has a critical role in uterine gland morphogenesis through amplifying Wnt-beta-catenin signaling PMID: 23975934
    30. Multi-functional norrin is a ligand for the LGR4 receptor. PMID: 23444378
    31. Lgr4/Gpr48 plays a critical role in modulating the TLR2/4 signaling pathway and represents a useful therapeutic approach of targeting Lgr4/Gpr48 in TLR2/4-associated septic shock and autoimmune diseases. PMID: 23589304
    32. Lgr4 signaling through Wnt/beta-catenin regulates peritubular myoid cells and is essential for spermatogenesis. PMID: 23533175
    33. Lgr4 is critically involved in the maintenance of intestinal homeostasis and protection against inflammatory bowel disease through modulation of the Wnt/beta-catenin signaling pathway PMID: 23393138
    34. LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis. PMID: 22738954
    35. GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression. PMID: 22135314
    36. Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state. PMID: 21523854
    37. Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine PMID: 21508962
    38. Relationship between the functions of Lgr4 and female reproductive systems. PMID: 20638054
    39. GPR48 is one of the constituents responsible for the EGFR signaling pathway with its effects directly linked to its ligand, HB-EGF. PMID: 20732323
    40. Gpr48 participates in the development of the male epididymis and efferent ducts through regulation of ERalpha expression via the cAMP/PKA signaling pathway. PMID: 20023170
    41. LGR4 is an important signaling molecule implicated in the tube morphogenesis of the male reproductive tract PMID: 16406039
    42. Lgr4 has pivotal roles to play in the regulation of ESR1 expression, the control of duct elongation through basement membrane remodeling, and the regional differentiation of the caput epididymidis. PMID: 17079737
    43. Lgr4 might be a novel gene class regulating cell motility PMID: 17850793
    44. Disruption of Gpr48 causes anterior segment dysgenesis through down-regulation of the Pitx2 gene. PMID: 18424556
    45. Inactivation of GPR48 induces the EOB phenotype by reducing epithelial cell proliferation and migration, indicating that GPR48 plays an essential role in eyelid development. PMID: 18487371
    46. Lgr4 might be a novel gene class regulating the development of hair follicles PMID: 18651655
    47. Gpr48/Lgr4 inactivation impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway PMID: 18955481
    48. Although Lgr4 hypomorphic mutant (Lgr4(Gt/Gt)) embryos developed a normal gall bladder bud at embryonic day (E) 10.25, no further elongation was observed at later stages PMID: 19301403
    49. Data demonstrate that Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway. PMID: 19605502

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:107515

    STRING: 10090.ENSMUSP00000047325

    UniGene: Mm.277351

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