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  4. Recombinant Mouse Laminin subunit alpha-5 (Lama5), partial

Recombinant Mouse Laminin subunit alpha-5 (Lama5), partial

  • 中文名称：
    小鼠Lama5重组蛋白
  • 货号：
    CSB-YP720233MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lama5重组蛋白
  • 货号：
    CSB-EP720233MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lama5重组蛋白
  • 货号：
    CSB-EP720233MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lama5重组蛋白
  • 货号：
    CSB-BP720233MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lama5重组蛋白
  • 货号：
    CSB-MP720233MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lama5
  • Uniprot No.：
    Q61001
  • 别名：
    Lama5; Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae.
  • 基因功能参考文献：
    1. the overriding effect of laminin 511 in the skin is inhibition of basal keratinocyte proliferation and migration. PMID: 27234307
    2. Study found that the extracellular matrix protein laminin-511 (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP. PMID: 28831020
    3. Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation PMID: 27208857
    4. The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress. PMID: 27940654
    5. According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time. PMID: 27064881
    6. Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5) may regulate appropriate hair morphogenesis. PMID: 23529140
    7. Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes. PMID: 24036115
    8. Laminin alpha 5 (Lama5) mRNA expressions in the lung of newborn in the nicotine treated Exp D1 decreased by 0.63 fold. PMID: 23755407
    9. These results suggest that laminin trimers containing alpha5 that are synthesized and secreted by endothelium or by trophoblasts are capable of integrating into the basement membrane and promoting normal vascularization of the placenta. PMID: 22911783
    10. mechanistic role of laminin-511 in tissue homeostasis PMID: 22666383
    11. amino acid residues within the short arm region of alpha5 that were critical for neurite outgrowth activity PMID: 22621685
    12. crystal structure of laminin alpha5LN-LE1-2 fragment shows the LN domain is a beta-jelly roll with several elaborate insertions; surface loop is required for stable ternary association with the beta- and gamma-short arms in the laminin network PMID: 21311558
    13. Downregulation of laminin-511 is important for hair regression. PMID: 20226633
    14. role in lobar septation and visceral pleural basement membrane formation in developing mouse lung PMID: 12051813
    15. several peptides of Laminin alpha 5 had cell attachment activity and the ability to promote neurite outgrowth. PMID: 12061820
    16. Results demonstrate that the alpha5 LG3 module is essential for the Lutheran blood group glycoprotein (Lu) binding to laminin alpha5. PMID: 12244066
    17. Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the G domain of this protein. PMID: 12519075
    18. Data suggest that laminin-10 (alpha5beta1gamma1) is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect. PMID: 12743034
    19. the laminin alpha5 chain is essential for normal development of the intestinal smooth muscle and point to possible mesenchyme-derived compensation to promote normal intestinal morphogenesis when laminin alpha5 is absent. PMID: 12921739
    20. crucial role for the LG4 module of laminin-alpha5 in epithelial morphogenesis that is distinct from that of the laminin-alpha1 LG4. PMID: 14568553
    21. Cryptic matrix epitope AQARSAASKVKVSMKF of laminin alpha 5 induces diverse inflammatory cell activities, including chemotaxis and expression of proteinases, cytokines, and cytokine receptors. PMID: 15661925
    22. Epithelial laminin alpha5 is necessary for murine lung development through signaling pathways that promote alveolar epithelial cell differentiation and VEGF expression. PMID: 15936333
    23. Laminin alpha5, a gene up-regulated during neural crest induction, is localized in regions of newly formed cranial and trunk neural folds and adjacent neural crest migratory pathways in a manner largely conserved between chick and mouse. PMID: 16316641
    24. A new mouse PKD model has been produced through insertion of a PGKneo cassette in an intron of the gene that encodes laminin alpha5 (Lama5). Lama5neo/neo mice exhibit PKD, proteinuria, and death from renal failure by 4 wk of age. PMID: 16790509
    25. The major contributions of laminin-5 to the resistance of the epidermis against frictional stress but also for basement membrane regeneration and repair of damaged skin are reflected by the phenotype of Herlitz junctional epidermolysis bullosa. PMID: 17000025
    26. podocyte foot process differentiation may require direct exposure to laminin alpha5 PMID: 17599968
    27. Laminin alpha 5 has a crucial role in establishing and maintaining the specific mucosal pattern of the mouse small intestine PMID: 18628307
    28. Laminin alpha5 directly inhibits integrin alpha(6)beta(1)-mediated migration of T lymphocytes through laminin alpha4. PMID: 19396173

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 组织特异性：
    In adult, high levels in heart, lung, and kidney; lower in brain, muscle and testis; very low in liver, gut and skin. Expressed in many tissues in embryonic day 11.
  • 数据库链接：

    KEGG: mmu:16776

    STRING: 10090.ENSMUSP00000015791

    UniGene: Mm.4339

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