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  4. Recombinant Mouse Laminin subunit alpha-2 (Lama2), partial

Recombinant Mouse Laminin subunit alpha-2 (Lama2), partial

  • 中文名称：
    小鼠Lama2重组蛋白
  • 货号：
    CSB-YP726665MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lama2重组蛋白
  • 货号：
    CSB-EP726665MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lama2重组蛋白
  • 货号：
    CSB-EP726665MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lama2重组蛋白
  • 货号：
    CSB-BP726665MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lama2重组蛋白
  • 货号：
    CSB-MP726665MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lama2
  • Uniprot No.：
    Q60675
  • 别名：
    Lama2; Laminin subunit alpha-2; Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能参考文献：
    1. These findings provide a mechanistic understanding of LAMA2 muscular dystrophy and establish a strong basis for a potential treatment. PMID: 28659438
    2. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination. PMID: 28636612
    3. results indicate a novel role for laminin-dystroglycan interactions in the cooperative integration of astrocytes, endothelial cells, and pericytes in regulating the Blood Brain Barrier. PMID: 25392494
    4. Laminin alpha2-mediated FAK activation in podocytes is an important early event in Alport glomerular pathogenesis. PMID: 24915008
    5. The effects of merosin knockout on alkaline phosphatase activity in the liver of normal and dystrophic mice is reported. PMID: 24680793
    6. Remodeling of extracellular matrix protein laminin may constitute an effort to revascularize and oxygenate the tissue following ischemic injury. PMID: 22759265
    7. The data of this study suggested that prosurvival Lama interactions in the developing postnatal VZ-SVZ germinal zone regulate the ability, or timing, of oligodendrocyte production to occur appropriately. PMID: 22706957
    8. Identification of cell adhesive sequences in the N-terminal region of the laminin alpha2 chain. PMID: 22654118
    9. Expression of autophagy-related genes is upregulated in laminin alpha2 chain-deficient muscle. PMID: 21920942
    10. alpha7 integrin is a modifier of disease progression in laminin-alpha2-deficient mice. PMID: 21652631
    11. Levels of both lipid rafts and raft-located acetylcholinesterase dimers increase in muscle of mice with muscular dystrophy by merosin deficiency. PMID: 20670915
    12. Overexpression of laminin alpha1 chain that lacks the dystroglycan binding LG4-5 domains in alpha2 chain deficient mice resulted in prolonged lifespan and improved health. PMID: 20657839
    13. These results suggest that the A2G78 and A2G80 sites play functional roles as heparan sulfate- and alpha-dystroglycan-binding sites in the laminin alpha2 chain LG4-5 module. PMID: 19800000
    14. Ku70 is a regulator of Bax-mediated pathogenesis in laminin-alpha2-deficiency muscle cells. PMID: 19692349
    15. Expression and distribution of laminin alpha2 in embryonic and adult mouse tissues PMID: 11969289
    16. this study identified a novel spontaneous mouse model of human congenital muscular dystrophy with laminin alpha2 chain deficiency, named dy(Pas)/dy(Pas). Homozygous animals rapidly developed a progressive muscular dystrophy leading to premature death. PMID: 12609503
    17. merosin contributes to muscle passive stiffness, viscoelasticity, and contractility PMID: 12736195
    18. Data show that merosin deficiency reduces fatigue and prolongs the duration of force potentiation in sternohyoid muscle from an animal model of merosin-deficient congenital muscular dystrophy. PMID: 12840158
    19. laminin alpha2 is essential for odontoblast differentiation and regulates the expression of dentin matrix proteins PMID: 14681233
    20. although alpha2-laminins are not essential for the initial assembly of costameric lattices of skeletal muscle sarcolemma, they play a role in maintaining the stability and organization of the framework PMID: 14734655
    21. Diseased muscles that lack laminin-alpha2 have altered compositions and proliferation of mononuclear cell populations. PMID: 15817132
    22. Lack of laminin alpha2 chain led to reduced laminin gamma 3 chain and abnormal testicular basement membranes; seminiferous tubules displayed defect in timing of lumen formation, resulting in production of fewer spermatides. PMID: 16127160
    23. Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice PMID: 16429580
    24. A decrease in laminin-alpha2 protein was observed in the muscle of alpha7-integrin-deficient mice and a decrease in mdx/alpha7-/- mice compared with wild-type mice. PMID: 16684813
    25. We observed production of laminin alpha2 in non-myogenic cells of normal mice, and we could enrich these laminin alpha2-producing cells in CD90(+) cell fractions. PMID: 17963748
    26. study describes defects in a new Lama2 allele, nmf417, in which a point mutation substitutes Arg for Cys79 at a conserved CxxC motif in laminin N-terminal domain; nmf417 homozygosity caused progressive myodegeneration & peripheral nerve root amyelination PMID: 18430779
    27. No muscle degeneration was evident; expression of various laminin chains was similar to that of limb muscles, and sustained integrin alpha7B expression was noted in laminin alpha2 chain-deficient laryngeal muscles. PMID: 19086066
    28. findings suggest that a normal role for CNS laminin is to promote the development of oligodendrocyte progenitors into myelin-forming oligodendrocytes via modulation of Fyn regulatory molecules PMID: 19776266

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  • 相关疾病：
    Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 数据库链接：

    KEGG: mmu:16773

    STRING: 10090.ENSMUSP00000090304

    UniGene: Mm.256087

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