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  4. Recombinant Mouse Kinase suppressor of Ras 1 (Ksr1), partial

Recombinant Mouse Kinase suppressor of Ras 1 (Ksr1), partial

  • 中文名称：
    小鼠Ksr1重组蛋白
  • 货号：
    CSB-YP012695MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ksr1重组蛋白
  • 货号：
    CSB-EP012695MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ksr1重组蛋白
  • 货号：
    CSB-EP012695MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ksr1重组蛋白
  • 货号：
    CSB-BP012695MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ksr1重组蛋白
  • 货号：
    CSB-MP012695MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ksr1
  • Uniprot No.：
    Q61097
  • 别名：
    Ksr1; Ksr; Kinase suppressor of Ras 1; mKSR1; EC 2.7.11.1; Protein Hb
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown.
  • 基因功能参考文献：
    1. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF. PMID: 27368419
    2. praja2 regulates KSR1 stability and mitogenic signaling. PMID: 27195677
    3. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding. PMID: 28003362
    4. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras. PMID: 25002533
    5. propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses PMID: 24158441
    6. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1. PMID: 24095280
    7. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation. PMID: 23431403
    8. Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model. PMID: 23221422
    9. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane. PMID: 23250398
    10. The loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development. PMID: 22301919
    11. a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1 PMID: 22206009
    12. Genetic disruption of KSR1 results in striking reductions in kit-ligand-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase. PMID: 21726514
    13. Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability. PMID: 21471251
    14. findings suggest that Ksr1 functions as a previously unknown scaffold that enhances iNOS activity and is therefore crucial for the pulmonary response to P. aeruginosa infections PMID: 21297617
    15. KSR1 is a functional protein kinase, MEK1 is an in vitro substrate of KSR1, and the catalytic activities of both proteins are required for eliciting cell survival responses downstream of TNF. PMID: 21144847
    16. despite a requirement for KSR1 for full ERK activation in thymocytes, full and efficient ERK activation is not essential for the majority of thymocyte selection events. PMID: 20865788
    17. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. PMID: 11751383
    18. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo PMID: 11940661
    19. evidence for interaction of Nm23-H1 and the suppressor of kinase Ras(KSR)in mammalian cells; can phosphorylate KSR via a histidine-dependent pathway PMID: 12105213
    20. Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR PMID: 12410604
    21. KSR1 permits coupling of ROCK to the actin polymerization machinery and its effects are mediated by the C-terminal domain of KSR1 PMID: 12588996
    22. molecular scaffold KSR1 regulates the intensity and duration of ERK activation to modulate a cell's proliferative and oncogenic potential PMID: 15121859
    23. Data demonstrate that phosphorylation and stability of the molecular scaffold KSR1 are critical regulators of growth factor-specific responses that promote cell proliferation. PMID: 15371409
    24. KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways PMID: 15520859
    25. Deletion of KSR1 prevents adipogenesis in vitro, which can be rescued by introduction of low levels of KSR1 PMID: 16107706
    26. KSR1 is a member of a unique class of proteins whose deletion blocks both cell senescence and transformation PMID: 16507997
    27. absence of KSR1 leads to deficits in associative learning and theta burst stimulation-induced LTP PMID: 16731514
    28. KSR1 as a caspase target and suggest that cleavage of the KSR1 scaffold represents another mechanism whereby caspases down-regulate ERK survival signaling to promote cellular apoptosis. PMID: 17613518
    29. NM23-H1 and its interacting partner STRAP physically interact with p53 and positively regulate its functions, including p53-induced apoptosis and cell cycle arrest PMID: 17916563
    30. KSR1 is recruited to the immunological synapse during T-cell activation; membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse. PMID: 19139278
    31. a specific role for the molecular scaffold KSR1 and KSR1-mediated ERK signaling in the cellular response to DNA interstrand cross-links. PMID: 19147494
    32. These findings provide unique insight into the signaling dynamics of the KSR1 scaffold. PMID: 19541618

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family
  • 组织特异性：
    Expressed in brain, spleen and testis. Isoform 1 is highly expressed spleen and weakly in testis, and isoform 2 is highly expressed in brain and weakly in testis.
  • 数据库链接：

    KEGG: mmu:16706

    STRING: 10090.ENSMUSP00000018478

    UniGene: Mm.4745

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