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  4. Recombinant Mouse Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (Hscb)

Recombinant Mouse Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (Hscb)

  • 中文名称：
    小鼠Hscb重组蛋白
  • 货号：
    CSB-YP810386MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hscb重组蛋白
  • 货号：
    CSB-EP810386MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hscb重组蛋白
  • 货号：
    CSB-EP810386MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hscb重组蛋白
  • 货号：
    CSB-BP810386MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hscb重组蛋白
  • 货号：
    CSB-MP810386MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hscb
  • Uniprot No.：
    Q8K3A0
  • 别名：
    Hscb; Hsc20; Iron-sulfur cluster co-chaperone protein HscB [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB; mitochondrial; C-HSC20); Iron-sulfur cluster co-chaperone protein HscB; cytoplasmic]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-234
  • 氨基酸序列
    A AAGKSIAPQC WNCGHAREAG CGDEFFCSHC RALQPPDPTR DYFSLMNCNR SFRVDVTKLQ HRYQQLQRLV HPDFFSQKSQ TEKHFSDKHS TLVNDAYKTL QAPLTRGLYL LKLQGIEIPE GTDYKADSQF LVEIMEINER LADAQSEAAM EEIEATVRAK QKEFTDNINS AFEQGDFEKA KELLTKMRYF SNIEEKIKLS KTPL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.
  • 亚细胞定位：
    [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm.; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion.
  • 蛋白家族：
    HscB family
  • 数据库链接：

    KEGG: mmu:100900

    STRING: 10090.ENSMUSP00000062811

    UniGene: Mm.200231

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