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  4. Recombinant Mouse Interferon regulatory factor 9 (Irf9)

Recombinant Mouse Interferon regulatory factor 9 (Irf9)

  • 中文名称：
    Recombinant Mouse Interferon regulatory factor 9 (Irf9)
  • 货号：
    CSB-EP011824MO
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Irf9
  • Uniprot No.：
    Q61179
  • 别名：
    IRF-9;IFN-alpha-responsive transcription factor subunit;ISGF3 p48 subunit;Interferon-stimulated gene factor 3 gamma;ISGF-3 gamma;Transcriptional regulator ISGF3 subunit gamma
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    51.5 kDa
  • 表达区域：
    1-399aa
  • 氨基酸序列
    MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFKAWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTLPNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNCNSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAERSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLITVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Irf9 Proteins

靶点详情

  • 功能：
    Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • 基因功能参考文献：
    1. Surface features in the interacting domains of IRF9 and STAT2 have diverged to enable specific interaction between these family members and to enable the antiviral response. PMID: 29317535
    2. findings illustrate an essential role for IRF9, as a mediator downstream of IFNAR, in preventing overwhelming antigen exposure causing CD8(+) T cell exhaustion and leading to chronic viral infection. PMID: 28878077
    3. We found that STAT-1(-/-) MRL lpr m, but not IRF-9(-/-) or IFNAR-2(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils. PMID: 26636548
    4. IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 and STAT2 than IRF9; and 2) signaling pathways not involving STAT1, STAT2, or IRF9 play a minor role only in mediating IFN-alpha-stimulated genes expression in MGCs. PMID: 28213522
    5. IRF9 is a vascular injury-response molecule that promotes VSMC proliferation. IRF9 expression is upregulated during neointima formation. PMID: 25319116
    6. IFN-alpha/beta is able to drive the formation of a Stat2 and IRF-9 complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics. PMID: 26019270
    7. In a murine model of dextran sodium sulfate -induced colitis, IRF9 deficiency protects animals, whereas the combined loss of interferon I and interferon III receptors worsens their condition. PMID: 25918247
    8. STAT2/IRF9 regulates antiviral activity through a prolonged ISGF3-like transcriptional response. PMID: 25564224
    9. IRF9 mediated myocardial reperfusion injury PMID: 25150882
    10. IRF9 directly activates neuronal death signaling pathways through the downregulation of Sirt1 deacetylase in response to acute I/R stress. PMID: 25186738
    11. IFN-beta-induced necroptosis of macrophages proceeds through tonic IFN-stimulated gene factor 3 (ISGF3) signaling, which leads to persistent expression of STAT1, STAT2, and IRF9 and sustained Rip3 activation. PMID: 25049377
    12. IRF9 inhibits the development of cardiac hypertrophy by suppressing the transcriptional activity of myocardin in the heart. PMID: 24144649
    13. Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice. PMID: 23471885
    14. STAT1, not STAT2 or IRF9, prevent the emergence of a lethal antiviral CD4(+) T-cell response after lymphocytic choriomeningitis virus infection. PMID: 22496215
    15. role for IRF9 in immune regulation within the gut mucosa PMID: 20428250
    16. Through association of IFN-responsive factor 9 (IRF9) with the IFN stimulation response element, IFN-alpha enhances both the induction and maintenance of programmed death (PD)-1 expression on T cell receptor-engaged primary mouse T cells. PMID: 21263073
    17. analysis of IFN-stimulated response elements (ISREs) that bind to both the IFN-stimulated gene factor 3 (ISGF3) as well as to IFN response factor 7 (IRF7) PMID: 20943654
    18. NOD1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections PMID: 20389019
    19. Transcriptional amplification requires recruitment of the interferon-stimulated gene factor 3 (ISGF3) complex upon activation of myeloid dendritic cells. PMID: 20083668
    20. upregulated during lymphocytic choriomeningitis virus infection, a process dependent on IFN-alpha/beta not IFN-gamma PMID: 15919906
    21. Upregulation of TLR7 by IFN-alpha was greatly reduced in Irf9 -/- and Stat1 -/- B cells PMID: 18340381

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    IRF family
  • 数据库链接：

    KEGG: mmu:16391

    STRING: 10090.ENSMUSP00000120525

    UniGene: Mm.2032

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