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  4. Recombinant Mouse Intelectin-1a (Itln1)

Recombinant Mouse Intelectin-1a (Itln1)

  • 中文名称：
    小鼠Itln1重组蛋白
  • 货号：
    CSB-YP011901MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Itln1重组蛋白
  • 货号：
    CSB-EP011901MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Itln1重组蛋白
  • 货号：
    CSB-EP011901MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Itln1重组蛋白
  • 货号：
    CSB-BP011901MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Itln1重组蛋白
  • 货号：
    CSB-MP011901MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itln1
  • Uniprot No.：
    O88310
  • 别名：
    Itln1; Intl; Itln; Itln1a; Itlna; Intelectin-1a; Galactofuranose-binding lectin; Intestinal lactoferrin receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-298
  • 氨基酸序列
    A EENLDTNRWG NSFFSSLPRS CKEIKQEHTK AQDGLYFLRT KNGVIYQTFC DMTTAGGGWT LVASVHENNM RGKCTVGDRW SSQQGNRADY PEGDGNWANY NTFGSAEAAT SDDYKNPGYF DIQAENLGIW HVPNKSPLHN WRKSSLLRYR TFTGFLQHLG HNLFGLYKKY PVKYGEGKCW TDNGPALPVV YDFGDARKTA SYYSPSGQRE FTAGYVQFRV FNNERAASAL CAGVRVTGCN TEHHCIGGGG FFPEGNPVQC GDFASFDWDG YGTHNGYS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind mammalian glycans. Probably plays a role in the defense system against microorganisms. May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption.
  • 基因功能参考文献：
    1. these studies conclude that ITLN contributes to allergen-induced Il-25, Il-33, and Tslp expression in asthma and atopic dermatitis PMID: 28224996
    2. Omentin protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/NOS3-dependent mechanism. PMID: 27607575
    3. omentin reduces the development of atherosclerosis by reducing inflammatory response of macrophages through the Akt-dependent mechanisms PMID: 26714927
    4. miR-584 contributes to the post-transcriptional expression of lactoferrin receptor during the perinatal period. PMID: 19665576
    5. Intelectin, a molecule expressed by airway epithelial cells and upregulated in asthma, is required for IL-13-induced MCP-1 and -3 production in mouse lung epithelial cells and contributes to allergic airway inflammation. PMID: 19965981
    6. Data show that the mouse lactoferrin receptor (MLfR) functions as a receptor for MLf, is expressed and localized in various tissues, and may be involved in the indispensable function of MLf during early embryonic development. PMID: 15222482
    7. Strategic localization of intelectin at the enterocyte brush border suggests that trimeric intelectin serves as an organizer and stabilizer of the brush border membrane. PMID: 16866365
    8. These findings support the notion that until the development-dependent expression of DMT1 in the intestine is induced, mouse LfR may serve as an alternative iron uptake pathway. PMID: 16936804
    9. intelectin is a host defense lectin that assists phagocytic clearance of microorganisms. PMID: 19179460

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
  • 组织特异性：
    Expressed in small intestinal Paneth cells in uninfected mice. Expression also detected in various other tissues including stomach, kidney, ovary and brain.
  • 数据库链接：

    KEGG: mmu:16429

    STRING: 10090.ENSMUSP00000043837

    UniGene: Mm.247426

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