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  4. Recombinant Mouse Integrin alpha-V (Itgav), partial

Recombinant Mouse Integrin alpha-V (Itgav), partial

  • 中文名称：
    小鼠Itgav重组蛋白
  • 货号：
    CSB-YP011877MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Itgav重组蛋白
  • 货号：
    CSB-EP011877MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Itgav重组蛋白
  • 货号：
    CSB-EP011877MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Itgav重组蛋白
  • 货号：
    CSB-BP011877MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itgav
  • Uniprot No.：
    P43406
  • 别名：
    Itgav; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 act as a receptor for CD40LG.
  • 基因功能参考文献：
    1. Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis PMID: 29061963
    2. Unaffected by Postn, Vav-Itgav(-/-) haematopoietic stem cell proliferate faster in vitro, illustrating the importance of Postn-Itgav interaction. PMID: 27905395
    3. These results demonstrate that OPN expressed by fatigue-resistant/slow motor neurons is involved in the second-wave neurodegeneration by up-regulating MMP-9 through alphavbeta3 integrin in the mouse model of amyotrophic lateral sclerosis. PMID: 27264390
    4. Angiogenic activity in the atherosclerotic plaques coincides with alphavbeta3-integrin by the adventitial vasa vasorum and intraplaque neovascularization. PMID: 27302657
    5. Tat PTD-Endostatin-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat PTD-Endostatin-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases. PMID: 27233450
    6. The synergy of circulating factor suPAR and APOL1 G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD. PMID: 28650456
    7. Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM. PMID: 27493116
    8. Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta. PMID: 26901152
    9. This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity. PMID: 26965188
    10. the present results suggest that CS-E is capable of inhibiting OA-induced osteoclast differentiation by blocking the interaction of OA to integrin a5b3 and heparan sulfate proteoglycan . PMID: 25820496
    11. identify alphavbeta3 as the primary integrin heterodimer mediating shear stress-induced proinflammatory responses and as a key contributor to early atherogenic inflammation PMID: 26212910
    12. Therapeutic delivery of alphavbeta1 inhibitor attenuated bleomycin-induced pulmonary fibrosis and carbon tetrachloride-induced liver fibrosis. PMID: 25995225
    13. alphaVbeta6 integrin-deficiency results in periodontal pathogens invading gingiva and aortic adventitia and eliciting inflammasome activation. PMID: 26371120
    14. These results suggest that phloretin was an inhibitor of actin podosomes and sealing zone, disrupting alpha5beta3 integrin-c-Src-Pyk2/Syk signaling pathway for the regulation of actin cytoskeletal organization in osteoclasts. PMID: 25834823
    15. Lung histology revealed aberrant elastin production and impaired lung septation in oxygen-exposed lungs, while tropoelastin, integrin alphav, fibulin-1, fibulin-2 and fibulin-4 gene expression were elevated. PMID: 25428696
    16. Our study demonstrates that the sOPN/integrin alphav axis, which induces T cell chemotaxis toward macrophages, is critical for suppressing hyperinflammation during the first 3 h of endotoxemia. PMID: 25972484
    17. Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation. PMID: 25822023
    18. These results suggest that integrin alphavbeta3 mediates the synergetic regulation of Cbfa1 transcription activity by gravity and IGF-1 via PI3K signaling. PMID: 25263523
    19. Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.[ITGAV] PMID: 24294595
    20. beta3/kindlin-2 interaction promotes outside-in alphaVbeta3 signaling selectively, with biological consequences in vivo PMID: 25587038
    21. Data indicate that influenza A virus H1N1 increases collagen deposition, transforming growth factor beta (TGFbeta) activity, and levels of detectable alphavbeta6 integrin in lung. PMID: 25339175
    22. alpha5 and alphav integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo PMID: 25670798
    23. Integrin alphaVbeta3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells. PMID: 25488971
    24. results reveal that loss of alphav in epithelial cells that lack p53 promotes squamous cell carcinomas development PMID: 24469034
    25. These data suggest that therapeutics antagonizing alphaV integrin function could be used to prevent fibrotic PCO following cataract surgery. PMID: 24495224
    26. Integrin alphav beta3/Dap12 double-deficient developed profound osteoporosis. PMID: 25547154
    27. The integrin alpha5beta1-mediated extracellular matrix signal through the RGD sequence is involved in embryonic enchondral ossification. PMID: 24375788
    28. Integrin alphaVbeta8 activates angiosuppressive TGFbeta gradients in the brain, which inhibit endothelial cell sprouting. PMID: 25406396
    29. integrin alphavbeta8 is a marker of T regulatory cells and functions in a cell intrinsic manner in mediating the processing of latent TGF-beta1 from the latent TGF-beta1/GARP complex on the surface of Activated T regulatory cells. PMID: 25127859
    30. alphavbeta3 was necessary and sufficient for Slug activation PMID: 25117682
    31. There is a scaffolding role for 14-3-3theta in assisting the delivery of Cx43 and integrin alpha5 to the plasma membrane for the formation of mechanosensitive hemichannels in osteocytes. PMID: 24163432
    32. integrin alphav may be integral to a mechanosensing machinery in osteoblastic cells and involved in activation of a Src-JNK-YAP/TAZ pathway in response to mechanical stimulation. PMID: 24726648
    33. AKT activated by fluid flow shear stress directly phosphorylates Cx43 and integrin alpha5, and Ser-373 of Cx43 plays a predominant role in mediating the interaction between these two proteins and Cx43 hemichannel opening PMID: 24563481
    34. Integrin alphavbeta3 and thyroid hormones promote expansion of progenitors in embryonic neocortex. PMID: 24496617
    35. Overexpression of Prtg and Radil activates alpha5beta1-integrins to high-affinity conformational forms. PMID: 23744351
    36. GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent PMID: 24023288
    37. Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin alphaV. PMID: 23933892
    38. regulates enamel biomineralization PMID: 23264742
    39. study provides evidence that (99m)Tc-RGD-4CK is a promising agent for noninvasive determination of alphabeta3 integrin status and therapy monitoring in BAC PMID: 23867618
    40. The expression of PDGFRalpha and CD51 among bone marrow stromal cells characterizes a large fraction of nestin+ cells containing most fibroblastic CFUs, mesenspheres, and self-renewal capacity after transplantation PMID: 23776077
    41. PDGF and integrin alphavbeta3 coordinate to have an antagonistic effect in the reactive oxygen species production at focal adhesion sites to regulate cell adhesion and migration. PMID: 23465490
    42. alphavbeta8 integrin, via interactions with RhoGDI1, regulates activation of Rho proteins to promote glioblastoma multiforme cell invasiveness. PMID: 23283986
    43. High alphav Integrin expression is associated with inflammatory neovascularization during graft-versus-host disease. PMID: 23327924
    44. Data indicate that the effect of TLR4 signaling was mainly mediated by nuclear factor-kappaB (NF-kappaB), and suggest that the combination of NF-kappaB inhibitor and alphavbeta3 antagonist would be a novel therapeutic option for the prevention of tumor metastasis. PMID: 22494046
    45. expression of alphavbeta3 suppresses activation of RhoA thus inhibiting LIMK1 phosphorylation of cofilin. indicates that alphavbeta3 integrin suppresses the RhoA/ ROCK/LIMK1 pathway. PMID: 23362664
    46. Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity. PMID: 23028753
    47. Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner. PMID: 22885106
    48. The Protein kinase D (PKD) mediates signals from the platelet-derived growth factor receptor (PDGF-R) to control alphavbeta3 integrin recycling. PMID: 22975325
    49. Podocyte VEGF-A regulates alpha(V)beta(3) integrin signaling in the glomerulus. PMID: 22808199
    50. These results indicate that DICAM acts as a negative regulator of osteoclast differentiation by suppressing the integrin alphaVbeta3 pathway. PMID: 22492581

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
  • 蛋白家族：
    Integrin alpha chain family
  • 数据库链接：

    KEGG: mmu:16410

    STRING: 10090.ENSMUSP00000028499

    UniGene: Mm.227

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