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  4. Recombinant Mouse Integrin alpha-IIb (Itga2b), partial

Recombinant Mouse Integrin alpha-IIb (Itga2b), partial

  • 中文名称：
    小鼠Itga2b重组蛋白
  • 货号：
    CSB-YP865567MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Itga2b重组蛋白
  • 货号：
    CSB-EP865567MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Itga2b重组蛋白
  • 货号：
    CSB-EP865567MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Itga2b重组蛋白
  • 货号：
    CSB-BP865567MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Itga2b重组蛋白
  • 货号：
    CSB-MP865567MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itga2b
  • Uniprot No.：
    Q9QUM0
  • 别名：
    Itga2b; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
  • 基因功能参考文献：
    1. alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia. PMID: 28815933
    2. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin. PMID: 28954813
    3. Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling. PMID: 26790499
    4. platelets clearly support early steps in pulmonary metastasis via GPIIb-dependent formation of platelet-tumor-aggregates PMID: 28253287
    5. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals. PMID: 27010197
    6. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. PMID: 25298035
    7. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation. PMID: 24969775
    8. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. PMID: 24523237
    9. reduction of talin-beta3 integrin binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding PMID: 24585775
    10. deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation. PMID: 24385425
    11. Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation. PMID: 24030382
    12. Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation. PMID: 23640884
    13. These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen. PMID: 23216754
    14. Here we show that platelet integrin CD41 (alphaIIb), currently thought to only transiently mark fetal hematopoietic stem cells, is expressed on an adult subtype that accumulates with age. PMID: 23564910
    15. identified Hic-5 as a novel and specific regulatory factor for thrombin-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice. PMID: 22812543
    16. These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality. PMID: 22730538
    17. Impaired spreading on fibrinogen and clot retraction with normal levels of alpha(IIb)beta(3) was observed in Lgals1(-/-) platelets, indicating a failure in the "outside-in" signaling through this integrin. PMID: 22456341
    18. Glycoprotein IIb/IIIa-targeted microbubbles specifically bind to activated platelets in vitro, allowing real-time molecular imaging of acute arterial thrombosis in a mouse model. PMID: 22647975
    19. Data indicate that the inflammatory cytokines TNF-alpha and IL-1 could be key components of the endothelial cell (EC) response and alphaIIb-beta3 integrin in platelets was required for late-phase thrombus stability. PMID: 22096246
    20. Only the threonine 410 gets dephosphorylated, possibly in an integrin aIIbb3-dependent manner PMID: 21645497
    21. Murine CD41 is a unique marker of the earliest hematopoietic cells that emerge from the mesodermal (brachyury+) compartment and contribute first to primitive hematopoiesis and definitive hematopoiesis in the blood island region of the murine yolk sac. PMID: 21618089
    22. differential and temporal expression of CD41 by hematopoietic stem cells in the distinct hematopoietic territories suggests a developmental/dynamic regulation of this marker throughout development. PMID: 21415271
    23. Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 facilitates delayed but sustained integrin activation PMID: 20971951
    24. vinculin is not required for the traditional functions of alpha(IIb) beta(3) or the platelet actin cytoskeleton PMID: 20670372
    25. Studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions. PMID: 20947017
    26. The involvement of fibronectin/RGD-binding integrins including alpha3beta1 and alpha5beta1 as well as glycoprotein IIb in megakaryocyte-induced osteoblast proliferation, was examined. PMID: 20052668
    27. Thrombin-stimulated PP1cgamma(-/-) platelets showed decreased alpha(IIb)beta(3) activation despite comparable levels of alpha(IIb)beta(3), PAR3, PAR4 expression and normal granule secretion. PMID: 20016849
    28. important role for PI3K p110 beta in regulating the avidity of high affinity integrin alpha(IIb)beta(3) receptors, necessary for the cellular transmission of contractile forces PMID: 19940148
    29. study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA PMID: 20075254
    30. Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. PMID: 11686325
    31. Integrin alpha 2b is expressed in midgestation embryos at sites of hematopoietic stem cell generation and multiple lineages derive from c-kit(+)alphaIIb(+) progenitors. PMID: 11884039
    32. integrin alpha(IIb)beta3 activation is induced by G12/G13 activated Gi-mediated signaling pathways PMID: 12183468
    33. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. PMID: 12393529
    34. The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. PMID: 12871637
    35. Results suggest that CD41 expression marks the onset of primitive and definitive hematopoiesis in the murine embryo and persists as a marker of some stem and progenitor cell populations in the fetal liver and adult marrow. PMID: 12900455
    36. caspase-12 participates in the development of fully functional signaling pathways linking some G-protein-coupled receptors to alphaIIbbeta3 activation. PMID: 15059849
    37. integrin alpha(IIb)beta3 adhesive function is regulated by platelet FXIII and calpain PMID: 15131115
    38. alpha IIb beta 3 signaling in platelets is regulated by SHIP1 and Lyn kinase PMID: 15166241
    39. CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect PMID: 15226180
    40. T176 I mutation, located in the N-terminal region in the W3:1-2 connecting strand of the beta-propeller, reveals the N-terminal alpha IIb domain plays an important structural role in the formation of heterodimer and is also involved in fibrinogen binding PMID: 15543332
    41. A function for GPIIb on mast cells is suggested by the altered adhesion of gbIIb-/- bone marrow mast cells to fibronectin- and vitronectin-coated surfaces. GPIIb could influence the in vivo differentiation or homing of tissue mast cells. PMID: 15781330
    42. the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin assembly by spread platelets PMID: 16051597
    43. GP IIb not only mediates platelet aggregation but also triggers platelet adhesion to exposed extracellular matrices and dysfunctional endothelial cells PMID: 16103235
    44. Time to half-disappearance of pro-alphaIIb (t1/2) was the same in (1) HEK293 cells transfected with (a) alphaIIb plus beta3, (b) alphaIIb alone, (c) mutant beta 3 and beta3-null megakaryocytes. PMID: 16304048
    45. TSSC6 appears to regulate integrin alpha(IIb)beta(3) "outside-in" signaling events in platelets and is necessary for stability of arterial thrombi in vivo. PMID: 16720835
    46. Megakaryote cells in bone marrow cells contain this antigen. PMID: 17420226
    47. talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo PMID: 18086863
    48. support an unsuspected role of alphaIIbbeta3/serotonin transporter(SERT)associations as well as alphaIIbbeta3 activation in control of SERT activity in vivo PMID: 18317590
    49. Protein phosphatase 2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 signaling pathway PMID: 18334487
    50. interaction with alphaIIbbeta3; and, consequently, the two src-family kinases can mediate different functional responses. PMID: 18430780

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 数据库链接：

    KEGG: mmu:16399

    STRING: 10090.ENSMUSP00000099375

    UniGene: Mm.26646

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