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  4. Recombinant Mouse Integrin alpha-3 (Itga3), partial

Recombinant Mouse Integrin alpha-3 (Itga3), partial

  • 中文名称：
    小鼠Itga3重组蛋白
  • 货号：
    CSB-YP737083MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Itga3重组蛋白
  • 货号：
    CSB-EP737083MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Itga3重组蛋白
  • 货号：
    CSB-EP737083MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Itga3重组蛋白
  • 货号：
    CSB-BP737083MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Itga3重组蛋白
  • 货号：
    CSB-MP737083MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itga3
  • Uniprot No.：
    Q62470
  • 别名：
    Itga3Integrin alpha-3; CD49 antigen-like family member C; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
  • 基因功能参考文献：
    1. These results demonstrate multiple roles of integrin-alpha3 at the neuromuscular junction. PMID: 28386022
    2. K63-linked polyubiquitination of Akt plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required for ureteric bud development and may represent a novel mechanism whereby integrins regulate signaling pathways. PMID: 25808491
    3. alpha3beta1-dependent alternative polyadenylation of MMP-9 mRNA occurs through a signaling pathway that involves extracellular signal-regulated kinase/mitogen-activated protein kinases. PMID: 25751421
    4. NR1, a novel antioxidant, ameliorated glucose-induced impaired podocyte adhesive capacity and subsequent podocyte depopulation partly through a3b1 integrin upregulation. PMID: 25503068
    5. This study reveals a previously unidentified role of laminin-111 in early stem cell differentiation.[Laminin-111] PMID: 24706882
    6. These findings demonstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fibulin-2 and other genes that promote matrix remodeling and invasion. PMID: 24694902
    7. Activation of signaling cascades downstream from alpha3beta1 integrin promotes prosurvival and proproliferative signals required for the malignant growth of basal mammary epithelial cells. PMID: 24077284
    8. modest reductions in Integrin alpha3 function, as measured in in vitro assays, can have a substantial impact on metastatic behavior in vivo PMID: 24002891
    9. integrin alpha3beta1 has a role in basement membrane stability through fibulin-2 induction, both in neonatal skin and in adult wounds PMID: 24390135
    10. GPR56 functions together with alpha3beta1 integrin in regulating cerebral cortical development. PMID: 23874761
    11. Results indicate that the basement membrane extract (BME) embedment of islets can up-regulate the expression of alpha3 integrin and its signal transduction, which may improve islet viability. PMID: 23587851
    12. During myoblast fusion integrin alpha3 associates with integrin beta1 and ADAM12, and also CD9 and CD81. PMID: 23671573
    13. overexpression of mesangial integrin alpha1 and podocyte vimentin and integrin alpha3 may be important features of glomerular Alport disease PMID: 23236390
    14. In the absence of alpha3beta1, tumor initiation is dramatically decreased because of increased epidermal turnover, leading to a loss of 7,12-dimethylbenzanthracene-initiated label-retaining keratinocytes. PMID: 23236172
    15. The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1 PMID: 22728432
    16. alpha3beta1 integrin-mediated stimulation of the Rac/PAK pathway is required for the inhibition of myosin light-chain kinase activity, permitting completion of the myoepithelial cell contraction/relaxation cycle and successful lactation. PMID: 21487391
    17. We show that integrin alpha3beta1 is a positive regulator of endothelial-VEGF PMID: 20639457
    18. analysis of its promoter activity PMID: 12230564
    19. cathepsin L and alpha(3) integrin have roles in podocyte migration PMID: 15197181
    20. Integrin alpha3beta1 has a role in directing the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1 PMID: 15265981
    21. Alpha3beta1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes PMID: 15728252
    22. results suggested that core fucosylation is essential for the functions of alpha3beta1 integrin PMID: 17043354
    23. role for alpha3beta1 in augmenting TGFbeta-mediated induction of MMP-9 in immortalized or transformed keratinocytes during skin carcinogenesis PMID: 17762853
    24. Alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain. PMID: 17848500
    25. The gamma 2 chain C-terminus plays an indirect but essential role in laminin-332 recognition by alpha 3 beta 1 integrin and, hence, its cellular functions. PMID: 18045589
    26. alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. PMID: 18246199
    27. Results identify non-overlapping functions of integrins alpha3beta1, alpha7beta1 and alpha6beta1 on different laminin isoforms, and suggest a role for these interactions in controlling neurite outgrowth from adult DRG neurons. PMID: 18590826
    28. Data suggest that integrin alpha3beta1 is a critical coordinator of epithelial-mesenchyme transition signaling pathways involving beta-catenin and pSmad2. PMID: 19104148
    29. integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed. PMID: 19118220
    30. alpha3beta1 integrin, a major laminin receptor, and c-Met, the receptor for hepatocyte growth factor, signal coordinately to regulate the expression of Wnt7b in the papilla of the developing kidney PMID: 19176588
    31. six genes (Csk, Itga3, Jarid2, Prkaca, Rarg, and Sall4), known to cause NTDs when deleted, that are also down-regulated in p53 -/- embryos. PMID: 19229884
    32. netrin-1-alpha3beta1 integrin interactions modulate distinct routes of interneuronal migration and the consequent positioning of groups of cortical interneurons in the developing cerebral cortex. PMID: 19383784
    33. These findings identify a novel role for alpha3beta1 integrin in promoting wound angiogenesis through a mechanism of crosstalk from epidermal to endothelial cells, and they implicate MRP3 in this integrin-dependent crosstalk. PMID: 19435806

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed in heart and brain. Only isoform 1 is detected in lung.
  • 数据库链接：

    KEGG: mmu:16400

    STRING: 10090.ENSMUSP00000001548

    UniGene: Mm.57035

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