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  4. Recombinant Mouse Integrin alpha-1 (Itga1), partial

Recombinant Mouse Integrin alpha-1 (Itga1), partial

  • 中文名称：
    小鼠Itga1重组蛋白
  • 货号：
    CSB-YP666304MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Itga1重组蛋白
  • 货号：
    CSB-EP666304MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Itga1重组蛋白
  • 货号：
    CSB-EP666304MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Itga1重组蛋白
  • 货号：
    CSB-BP666304MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Itga1重组蛋白
  • 货号：
    CSB-MP666304MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itga1
  • Uniprot No.：
    Q3V3R4
  • 别名：
    Itga1; Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD antigen CD49a
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
  • 基因功能参考文献：
    1. the cross-talk between SFRP4, integrin alpha1beta1, and Notch1 suppresses the cardiac differentiation of P19CL6 cells. PMID: 27542621
    2. Data show that in the absence of Langerhans Cells, CD49a(+) liver NK cells display an inappropriately proinflammatory phenotype that results in increased local skin inflammation. PMID: 26209621
    3. The decrease in hepatic lipid accumulation in HF-fed itga1(-/-) mice was associated with altered free fatty acid metabolism. These studies establish a role for integrin signaling in facilitating hepatic insulin action PMID: 25593319
    4. a crosstalk between integrin alpha1beta1 and TbetaRII is essential for TbetaRII-mediated SMAD activation and fibrotic signaling pathways PMID: 24983314
    5. Synthesis and modeling of linear and cyclic KTS-containing peptides is described that leads to their use as inhibitors of integrin alpha1beta1/alpha2beta1-mediated adhesion and other antiangiogenetic activity in human serum. PMID: 24939421
    6. Data indicate that integrin alpha1beta1 is a key participant in chondrocyte transduction of a hypo-osmotic stress. PMID: 24495803
    7. These findings predict a role for biomechanical insult in the induction of integrin alpha1beta1-dependent Rac1-mediated mesangial cell process invasion of the glomerular capillary tuft as an initiation mechanism of Alport glomerular pathology. PMID: 23911822
    8. Macrophages express the highest levels of alpha1 integrin in the inflamed footpad. PMID: 23509351
    9. overexpression of mesangial integrin alpha1 and podocyte vimentin and integrin alpha3 may be important features of glomerular Alport disease PMID: 23236390
    10. TSC2 controls cell migration, attachment, and spreading through the alpha1beta1-integrin receptor. PMID: 22923640
    11. Integrin alpha1KOAkitaKO Balb/c mouse represents a promising model presenting with most features of human diabetic nephropathy. PMID: 22297672
    12. Data show that the induction of collagen XIII in endothelial cells of Alport syndrome kidneys mediates the selective recruitment of alpha1beta1 integrin-positive monocytes. PMID: 20864678
    13. Collectively, our results suggest that vascular basement membrane components substantially impact gene expression in astrocytes during brain tissue repair. PMID: 20091789
    14. The ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1-dependent Cav-1 expression and consequent EGFR-mediated reactive oxygen species production. PMID: 20368353
    15. data suggest VLA-1 expression defines a population of tissue memory CD4(+) T cells that act as rapid effectors upon influenza reinfection PMID: 20200271
    16. Data demonstrate that engagement of leukocyte-associated alpha(1)beta(1) integrins with ECM plays a pivotal role in mediating intestinal inflammation via promotion of monocyte movement and/or activation within the inflamed interstitium. PMID: 12488427
    17. Integrin alpha 1 is rapidly induced and expressed on effector CD8+ T cells and selectively maintained on memory CD8+ T cells; its blockade inhibits adoptive transfer of antigen-specific delayed-type hypersensitivity responses. PMID: 12960301
    18. Deficiency in the alpha1 integrin subunit is associated with an earlier deregulation of cartilage homeostasis and an accelerated, aging-dependent development of osteoarthritis PMID: 14558093
    19. Alpha1beta1 integrin defines a unique population of peripheral lymph node-derived dendritic cells with altered functional properties and adhesive potential that localizes these cells to sites in lymph nodes where antigen presentation to T cells occurs. PMID: 14688336
    20. VEGF-A induced alpha1 & alpha2 integrins, promoting lymphatic endothelial tube formation & haptotactic migration. Lineage-specific integrin receptor expression contribute to the distinct dynamics of wound-associated angiogenesis & lymphangiogenesis. PMID: 15132990
    21. alpha1beta1 integrin is involved in atherosclerosis by mediating the migration of leukocytes to lesions by adhesion to collagen IV PMID: 15976328
    22. Together, these results show that integrin alpha1beta1 is an important mediator of the compatible osmolyte response in the medulla of the mammalian kidney. PMID: 16106035
    23. alpha1beta1 integrin, a major collagen receptor was expressed by MC615 cells PMID: 16198011
    24. lack of integrin alpha1beta1 exacerbates the glomerular injury in a mouse model of diabetes PMID: 16775606
    25. bone marrow-derived dendritic cell injected by either mesenteric lymph nodes (LN) or spleen and mediastinal LN activated CD8(+) T cells to up-regulate both alpha(4)beta(1) and alpha(4)beta(7) integrins. PMID: 17237400
    26. integrin alpha1beta1- epidermal growth factor receptor cross talk is a key step in negatively regulating Rac1 activation, reactive oxygen species production, and excessive collagen synthesis PMID: 17339338
    27. the interaction between Sema7A and alpha1beta1 integrin is crucial at the site of inflammation PMID: 17377534
    28. Emphasize the importance of alpha(1)beta(1)-integrin in p38 MAPK and FAK phosphorylation during vascular hypertrophy in response to ANG II. PMID: 17660399
    29. VLA-1 and tumor necrosis factor receptor type II (TNFR-II) synergize to protect effector CD8 T cells in influenza-infected airways from apoptosis during acute infection. PMID: 17911590
    30. Oxygen-glucose deprivation produced a further significant increase in subunit beta1 expression by both cell types, but a clear decrease in both alpha1 and alpha 6 subunits by murine astrocytes. PMID: 18032737
    31. Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt. PMID: 18245559
    32. Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells. PMID: 18258846
    33. results indicate that loss of integrin alpha1 subunit decreases incidence and growth of lung epithelial tumors initiated by oncogenic Kras, suggesting that both Kras and integrin alpha1beta1 cooperate to drive growth of non-small cell lung cancer in vivo PMID: 18676835
    34. These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment. PMID: 18832573

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 数据库链接：

    KEGG: mmu:109700

    STRING: 10090.ENSMUSP00000077132

    UniGene: Mm.317280

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