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  4. Recombinant Mouse Inositol 1,4,5-trisphosphate receptor type 3 (Itpr3), partial

Recombinant Mouse Inositol 1,4,5-trisphosphate receptor type 3 (Itpr3), partial

  • 中文名称：
    小鼠Itpr3重组蛋白
  • 货号：
    CSB-YP011914MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Itpr3重组蛋白
  • 货号：
    CSB-EP011914MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Itpr3重组蛋白
  • 货号：
    CSB-EP011914MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Itpr3重组蛋白
  • 货号：
    CSB-BP011914MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Itpr3重组蛋白
  • 货号：
    CSB-MP011914MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itpr3
  • Uniprot No.：
    P70227
  • 别名：
    Itpr3Inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 表达区域：
    2517 – 2670aa
  • 氨基酸序列
    DTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRV KNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVS HLTSQLNELKEQMTEQRKRRQRLGFVDVQNCMSR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
  • 基因功能参考文献：
    1. study demonstrated that IP3R-mediated Ca(2+) release plays an essential role in regulating B cell development, proliferation, Ab production, and B cell regulatory function in vivo PMID: 28615414
    2. the IP3R3-Ca(2+) pathway is required for nitric oxide-induced cardiomyocyte differentiation of embryonic stem cells. PMID: 27349290
    3. a spontaneous mutation of Itpr3 in a progenitor of the BTBR strain produces a heretofore unrecognized dysfunction of GPCR-mediated taste transduction PMID: 23859941
    4. IP3R3 expressing microvillous cells are actively responsive to injury and promote recovery PMID: 23516531
    5. IP(3)receptor-mediated activation of potassium channels provides a mechanism for glutamatergic and cholinergic inputs to selectively suppress striatal output neuron activity. PMID: 23392696
    6. The data suggested that that hair shedding is actively controlled by the IP3R3/NFAT-dependent signaling pathway, possibly through the regulation of cytokeratin filaments in keratinocytes. PMID: 22572820
    7. InsP3 receptors co-localize with ORAI calcium release-activated calcium modulator 1 (Orai1) channels in pancreatic acinar cells, even in IP3-deficient knockout mice. PMID: 21568942
    8. analysis of allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors PMID: 21150295
    9. These findings demonstrate that KRAP physically associates with IP(3)R and regulates the proper localization of IP(3)R in the epithelial cells in vivo and cultured cells. PMID: 21420385
    10. The characterization of IP3R3 microvillous cells as non-neuronal chemoresponsive cells helps to explain the differing descriptions of microvillous cells in the literature. PMID: 20958798
    11. Knockdown of IP(3)R3 by small interfering RNA increased apoptosis in differentiating cells but not in undifferentiated ES cells. PMID: 20075939
    12. Measurements of intracellular calcium changes show that both Itpr3 and ryanodine receptors are involved in a calcium-induced calcium release mechanism, which amplifies the initial Ca2+ influx through plasma membrane T-type calcium channels. PMID: 20519450
    13. evaluated its role in mediating TGF-beta induced Ca(2+) influx in mesangial cells PMID: 11934702
    14. concomitant loss of ITPR3 expression and consequent defects in Ca(2+) signaling, may substantially contribute to the mechanism of the loss of genomic discrimination, in vivo, between the fed and fasted states PMID: 12606813
    15. it is concluded that most IP3R are expressed in intracellular stores but a tiny fraction is reliably directed to the plasma membrane, where they contribute substantially to the Ca2+ entry evoked by the B-cell receptor PMID: 16840702
    16. IP3-R mediated calcium release modulates spontaneous activity in cardiomyocytes and may promote the appearance of arrhythmic activity. PMID: 17379641
    17. that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation. PMID: 17925404
    18. Itpr3 receptor regulates the differentiation of granule cell precursors after postnatal day 12 in the cerebellum. PMID: 18194433
    19. Gene expression of IP3 receptor(ITPR)-3 plays a key role in the activation and differentiation of CD4 T cells; ITPR-3 downregulation is associated with the failure of T cell receptor ligation to trigger calcium release in CD4 T cells. PMID: 19050248
    20. cell death dependence on the IP3-dependent calcium signaling PMID: 19692655

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    InsP3 receptor family
  • 数据库链接：

    KEGG: mmu:16440

    STRING: 10090.ENSMUSP00000038150

    UniGene: Mm.458106

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