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  4. Recombinant Mouse IgG receptor FcRn large subunit p51 (Fcgrt), partial

Recombinant Mouse IgG receptor FcRn large subunit p51 (Fcgrt), partial

In Stock
  • 中文名称：
    小鼠Fcgrt重组蛋白
  • 货号：
    CSB-EP717217MO
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Fcgrt
  • Uniprot No.：
    Q61559
  • 别名：
    FcRn;IgG Fc fragment receptor transporter alpha chain;Neonatal Fc receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    37.9
  • 表达区域：
    22-297aa
  • 氨基酸序列
    SETRPPLMYHLTAVSNPSTGLPSFWATGWLGPQQYLTYNSLRQEADPCGAWMWENQVSWYWEKETTDLKSKEQLFLEALKTLEKILNGTYTLQGLLGCELASDNSSVPTAVFALNGEEFMKFNPRIGNWTGEWPETEIVANLWMKQPDAARKESEFLLNSCPERLLGHLERGRRNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSSARSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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Fcgrt Proteins

靶点详情

  • 功能：
    Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
  • 基因功能参考文献：
    1. The main function of hepatic FcRn is to direct albumin into the circulation, thereby also increasing hepatocyte sensitivity to toxicity. PMID: 28330995
    2. Preproinsulin fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development. PMID: 25918233
    3. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. PMID: 25658443
    4. Characterization and screening of IgG binding to the neonatal Fc receptor. PMID: 24802048
    5. Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria PMID: 24357670
    6. Abundant intracellular IgG in enterocytes and endoderm lacking FcRn. PMID: 23923029
    7. Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding. PMID: 24652290
    8. FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance PMID: 24290911
    9. Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes. PMID: 23181795
    10. AMG 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose. PMID: 22189693
    11. an increase in lymphoid follicles and Helicobacter bacterial load in knock-out mice PMID: 22089027
    12. Data show that FcRn traps antigen and protects it from degradation within an acidic loading compartment in association with the rapid recruitment of key components of the phagosome-to-cytosol cross-presentation machinery. PMID: 21628593
    13. Findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs. PMID: 21402891
    14. These studies demonstrate that FcRn-mediated transport is a mechanism by which IgG can act locally in the female genital tract in immune surveillance and in host defense against sexually transmitted diseases. PMID: 21368166
    15. Fetal, but not maternal, FcRn is required for induction of Fetal and neonatal immune thrombocytopenia. PMID: 20647570
    16. No binding of albumin was observed at physiological pH to neonatal Fc receptor. At acidic pH, a 100-fold difference in binding affinity was observed. PMID: 20018855
    17. Mouse FcRn is promiscuous in its antibody binding specificity, interacting with IgG from human, mouse, rabbit, guinea pig, bovine, sheep and rat. PMID: 11717196
    18. Direct evidence is provided that FcRn is responsible for both perinatal IgG transport and IgG homeostatic function. PMID: 12646614
    19. FcRn promotes humorally mediated autoimmune disease. PMID: 15124024
    20. sequence analysis of promoter indicates that availability of specific TFs may contribute to the regulation of Fcgrt expression PMID: 15627500
    21. the amount of albumin saved from degradation by FcRn-mediated recycling is the same as that produced by the liver PMID: 16210471
    22. report a therapeutic strategy to beneficially alter the pharmacokinetics of IgG antibodies via pharmacological inhibition of the neonatal Fc receptor (FcRn) using high-dose IgG therapy PMID: 17717602
    23. Mice lacking FcRn accumulated IgG in the glomerular basement membrane as they aged, and tracer studies showed delayed clearance of IgG from the kidneys of FcRn-deficient mice PMID: 18198272
    24. FcRn maintains levels of pathogenic autoantibodies and thereby promotes tissue injury in experimental epidermolysis bullosa acquisita. PMID: 18542899
    25. A previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody, is shown. PMID: 18599440
    26. The intracellular trafficking pathway and functions of FcRn may be altered by the association of major histocompatibility (MHC) class II invariant chain (Ii) during physiological and inflammatory conditions. PMID: 18684948
    27. Results indicate that FcRn-dependent internalization of IgG may be important not only in cells taking up IgG from an extracellular acidic space, but also in endothelial cells participating in homeostatic regulation of circulating IgG levels. PMID: 18843053
    28. FcRn is responsible for virtually all immunoglobulin G transport from mother to fetus during gestation. PMID: 19234152
    29. renal FcRn reclaims albumin, thereby maintaining the serum concentration of albumin, but facilitates the loss of IgG from plasma protein pools PMID: 19661163

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.
  • 数据库链接：

    KEGG: mmu:14132

    STRING: 10090.ENSMUSP00000003512

    UniGene: Mm.3303

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