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  4. Recombinant Mouse Hypoxia up-regulated protein 1 (Hyou1), partial

Recombinant Mouse Hypoxia up-regulated protein 1 (Hyou1), partial

  • 中文名称：
    小鼠Hyou1重组蛋白
  • 货号：
    CSB-YP862399MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hyou1重组蛋白
  • 货号：
    CSB-EP862399MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hyou1重组蛋白
  • 货号：
    CSB-EP862399MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hyou1重组蛋白
  • 货号：
    CSB-BP862399MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hyou1重组蛋白
  • 货号：
    CSB-MP862399MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hyou1
  • Uniprot No.：
    Q9JKR6
  • 别名：
    Hyou1; Grp170; Hypoxia up-regulated protein 1; GRP-170; 140 kDa Ca(2+)-binding protein; CBP-140
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
  • 基因功能参考文献：
    1. The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygendeprived conditions PMID: 27748851
    2. Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins. PMID: 24327659
    3. These results suggest that although ORP150 is protective against bleomycin-induced lung injury, this protein could stimulate bleomycin-induced pulmonary fibrosis by increasing pulmonary levels of TGF-beta1 and myofibroblasts. PMID: 22892132
    4. Results reveal a previously unrecognized attribute of Grp170 as a superior DNA-binding chaperone capable of amplifying TLR9 activation on pathogen recognition. PMID: 22207611
    5. AICAR infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis PMID: 21296878
    6. Secreted grp170 can bind to and co-transport out of tumour cells a full length tumour antigen that may play a role in the anti-tumour immune response. PMID: 20210603
    7. Grp170 displays multiple peptide binding domains; the presence of two strong peptide binding regions in such a large protein may facilitate the interactions and assembly of two substate proteins. PMID: 14674765
    8. demonstrated that expression of ORP150 in developing brain most likely serves a cytoprotective function in Purkinje cells PMID: 14960622
    9. The 150-kDa oxygen-regulated protein may be cytoprotective against ischemia/reperfusion injury via reduction of endoplasmic reticulum stress and probably also inhibition of apoptosis. PMID: 15223375
    10. ORP150 exerts cytoprotective effects in renal tubular epithelia subjected to I/R injury and suggest a key role for ER stress in the renal tubular response to acute renal failure PMID: 15240565
    11. Systemic expression of ORP150 in Akita mice improves insulin intolerance, whereas the exclusive overexpression of ORP150 in pancreatic beta-cells of Akita mice did not change their glucose tolerance. PMID: 15734840
    12. involvement of ORP150 in insulin secretion in MIN6 cells PMID: 15841037
    13. molecular chaperoning is involved in stress protein interactions with APCs, antigen binding, and in eliciting antitumor immunity, thus bridging this ancient function of stress proteins in prokaryotes to their ability to elicit immunity in higher organisms PMID: 16424054
    14. Grp170 depleted of endoplasmic reticulum retention sequence "KNDEL," when secreted by B16 melanoma cells, maintains its highly efficient chaperoning activities and is significantly superior to both hsp70 and gp96. PMID: 16849461
    15. Our observations led to the hypothesis that ORP150 protects against MPTP/MPP(+)-induced neurotoxicity, and indicate the importance of the ER environment in maintaining the nigrostriatal pathways. PMID: 17330988
    16. Overexpression of ORP150 in mice leads to abetalipoproteinemia with alteration of glucose and lipid metabolism. PMID: 17605339
    17. These findings suggest that overexpression of ORP150 causes accumulation of ORP150 in the rough-surfaced endoplasmic reticula, resulting in vacuolar degeneration in the skeletal muscle of ORP-Tg mice. PMID: 18250584
    18. Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 PMID: 18483274
    19. grp170 elicits systemic tumor immunity and may be used to improve treatment outcomes for prostate cancer. PMID: 19142636

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  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Heat shock protein 70 family
  • 数据库链接：

    KEGG: mmu:12282

    STRING: 10090.ENSMUSP00000068594

    UniGene: Mm.116721

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