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  4. Recombinant Mouse Hyaluronidase-3 (Hyal3)

Recombinant Mouse Hyaluronidase-3 (Hyal3)

  • 中文名称：
    小鼠Hyal3重组蛋白
  • 货号：
    CSB-YP848696MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hyal3重组蛋白
  • 货号：
    CSB-EP848696MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hyal3重组蛋白
  • 货号：
    CSB-EP848696MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hyal3重组蛋白
  • 货号：
    CSB-BP848696MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hyal3重组蛋白
  • 货号：
    CSB-MP848696MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hyal3
  • Uniprot No.：
    Q8VEI3
  • 别名：
    Hyal3; Hyl3Hyaluronidase-3; Hyal-3; EC 3.2.1.35; Hyaluronoglucosaminidase-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-412
  • 氨基酸序列
    LLQVPEHP FSVVWNVPSA RCKAHFGVHL PLDALGIVAN HGQHFHGQNI SIFYKNQFGL YPYFGPRGTA HNGGIPQAVS LDHHLARAAH QILHSLGSSF AGLAVLDWEE WYPLWAGNWG PHRQVYLAAS WVWTQQMFPG LDPQEQLHKA HTSFEQAARA LMEYTLQLGR TLRPSGLWGF YRYPACGNGW HKMASNYTGH CHAAITTRNT QLRWLWAASS ALFPSIYLPP RLPLAYRQAF VRHRLEEAFR VALLEHSHPL PVLAYSRLTH RSSGRFLSLD DLMQTIGVSA ALGTAGVVLW GDLSFSSSEE KCWRLHDYLV GTLGPYVINV TKAAMACSHQ RCHGHGRCAR KDPGQMEAFL HLQPDDSLGA WNSFRCHCYS GWAGPTCLEP KP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
  • 基因功能参考文献：
    1. Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway. PMID: 21732362
    2. Hyal3 null sperm showed delayed cumulus penetration and reduced acrosomal exocytosis. PMID: 20586096
    3. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. PMID: 11929860
    4. Hyal3 may contribute to hyaluronan metabolism by augmenting the activity of Hyal1. PMID: 18234732
    5. Hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia. PMID: 18653706
    6. HYAL3 does not play a major role in constitutive hyaluronan degradation PMID: 18762256

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  • 亚细胞定位：
    Secreted. Cell membrane. Cytoplasmic vesicle, secretory vesicle, acrosome. Endoplasmic reticulum. Early endosome.
  • 蛋白家族：
    Glycosyl hydrolase 56 family
  • 组织特异性：
    Expressed in testis, epididymal tissue, epididymal luminal fluid (ELF), acrosome-intact (AI) sperm and caput (CAP), corpus (COR) and caudal (CAU) sperm. Higher expression in sperm than testis (at protein level). Liver, kidney, skin, brain, stomach and tes
  • 数据库链接：

    KEGG: mmu:109685

    STRING: 10090.ENSMUSP00000042667

    UniGene: Mm.447916

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