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  4. Recombinant Mouse Homeobox protein cut-like 2 (Cux2), partial

Recombinant Mouse Homeobox protein cut-like 2 (Cux2), partial

  • 中文名称：
    Recombinant Mouse Homeobox protein cut-like 2(Cux2) ,partial
  • 货号：
    CSB-YP006229MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein cut-like 2(Cux2) ,partial
  • 货号：
    CSB-EP006229MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein cut-like 2(Cux2) ,partial
  • 货号：
    CSB-EP006229MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein cut-like 2(Cux2) ,partial
  • 货号：
    CSB-BP006229MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein cut-like 2(Cux2) ,partial
  • 货号：
    CSB-MP006229MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cux2
  • Uniprot No.：
    P70298
  • 别名：
    Cux2; Cutl2Homeobox protein cut-like 2; Homeobox protein Cux-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.
  • 基因功能参考文献：
    1. CUX2 inhibited HNF6 transcriptional regulation of the sex-specific gene promoters CYP2C11 and CYP2C12, blocking HNF6 repression of CYP2C11 and HNF6 activation of CYP2C12. PMID: 26218442
    2. results suggest that the persistent expression of CUX2 in postmitotic neurons contributes to the maintenance of genome integrity through its stimulation of oxidative DNA damage repair. PMID: 26221032
    3. Results suggest that Cux2 expression reflects hippocampal neurogenesis and identifies non-self-renewing neural progenitors in the subgranular zone of the dentate gyrus PMID: 25252086
    4. Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia PMID: 25996137
    5. Cux2 activity plays an important role for ongoing neurogenesis in the olfactory epithelium PMID: 24512687
    6. The downregulation of CUX2 in male liver at puberty contributes to the developmental changes establishing adult patterns of sex-specific gene expression. PMID: 22966202
    7. Cux2 is expressed and may participate in development of a specific subtype of myelinated TrkA(+) nociceptors. PMID: 21945863
    8. Data suggest a lineage relationship between subventricular zone precursors, appearing as early as embryonic day 11.5, and upper cortical layer neurons. PMID: 15238450
    9. Cux-2 mRNA expression is found in the embryonic subventricular zone of the cerebral cortex, overlapping with bromodeoxyuridine-positive dividing precursors, but it is not expressed in the ventricular zone. PMID: 15452856
    10. Cux-2 is a key element in control of proliferation rates of subventricular zone precursors and number of upper cortical neurons, without altering the number of deep cortical layers. PMID: 18033766
    11. This work defines novel roles for Cux2 as a transcription factor that integrates cell-cycle progression with neural progenitor development during spinal cord neurogenesis. PMID: 18223201
    12. Cux-2 control the development of Reelin expressing cortical interneurons. PMID: 18327765
    13. Notch1 regulates Cux2 expression. Although Notch1 signaling can be inhibitory to the expression of proneural genes, it is also required for interneuron formation during spinal cord development. PMID: 19542352

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CUT homeobox family
  • 组织特异性：
    Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.
  • 数据库链接：

    KEGG: mmu:13048

    STRING: 10090.ENSMUSP00000083497

    UniGene: Mm.156172

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