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  4. Recombinant Mouse Homeobox protein DLX-2 (Dlx2)

Recombinant Mouse Homeobox protein DLX-2 (Dlx2)

  • 中文名称：
    小鼠Dlx2重组蛋白
  • 货号：
    CSB-YP006953MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dlx2重组蛋白
  • 货号：
    CSB-EP006953MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dlx2重组蛋白
  • 货号：
    CSB-EP006953MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dlx2重组蛋白
  • 货号：
    CSB-BP006953MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dlx2重组蛋白
  • 货号：
    CSB-MP006953MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dlx2
  • Uniprot No.：
    P40764
  • 别名：
    Dlx2; Tes-1; Tes1Homeobox protein DLX-2; Homeobox protein TES-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-332
  • 氨基酸序列
    MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGAGAGPGGN SNSSSSNSSL HKPQESPTLP VSTATDSSYY TNQQHPAGGG GGGASPYAHM GSYQYHASGL NNVSYSAKSS YDLGYTAAYT SYAPYGTSSS PVNNEPDKED LEPEIRIVNG KPKKVRKPRT IYSSFQLAAL QRRFQKTQYL ALPERAELAA SLGLTQTQVK IWFQNRRSKF KKMWKSGEIP TEQHPGASAS PPCASPPVSA PASWDFGAPQ RMAGGGPGSG GGGAGSSGSS PSSAASAFLG NYPWYHQASG SASHLQATAP LLHPSQTPQA HHHHHHHHHA GGGAPVSAGT IF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
  • 基因功能参考文献：
    1. Dlx2 overexpression may alter the alveolar bone, cementum and periodontal ligament (PDL) phenotypes in mice. PMID: 28447749
    2. the expression level and the spatiotemporal expression patterns of Dlx2 may be important in regulating the development of post-natal condyle in mice, and also offered a possible temporalmandibular joint osteoarthritis model animal for future studies. PMID: 27315306
    3. The activation of DLX2 signaling might improve tissue regeneration mediated by MSCs of dental origin. Results provide insight into the mechanism underlying the directed differentiation of MSCs of dental origin. PMID: 24756434
    4. the prethalamic factors Dlxs upregulated by Ascl1/Helt deficiency play unique roles in regulating thalamic progenitor specification. PMID: 25512300
    5. Dlx2 overexpression in neural crest stem cells may be a new pathogenesis of facial cleft and spinal kyphosis in mammals. PMID: 23246068
    6. Dlx2 is one critical player in shifting TGFbeta from its tumour suppressive to its tumour-promoting functions. PMID: 21897365
    7. Dlx2 and FoxJ1 physically interact and synergistically regulate the Dlx2, FoxJ1, and amelogenin promoters PMID: 21504905
    8. in hippocampal precursors Dlx2 promoted neurogenesis but not neural stem cell activation PMID: 20417282
    9. Results suggest that DLX2 and EGFR signalling interact at multiple levels to coordinate neuronal proliferation in the postnatal subventricular zone. PMID: 19683576
    10. ectopic expression of Dlx2 induced the expression of glutamic acid decarboxylases (GADs) PMID: 11782417
    11. Dlx2 has a role in deteriming mouse basal ganglia and neocortex axonal development PMID: 12421703
    12. Dlx-2 does not play a direct role in dopamine phenotypic differentiation and tyrosine hydroxylase gene regulation in adult olfactory bulb. Widespread expression of Dlx in adult brains suggests these genes may have additional roles in mature animals. PMID: 12722102
    13. In Nkx2.1 mutants, the early but not late populations of Dlx2-expressing cells originating in the ventral telencephalon that migrate to the cortex are lost. PMID: 12902388
    14. In this review, Dlx2 is an early bone morphogenetic protein 2 responsive gene in osteoblasts. PMID: 12957859
    15. The gene expression profile of Dlx2 subpallium was studied at different embryonic days. PMID: 15376329
    16. These results suggest a role for Dlx genes in regulating ectomesenchymal cell adhesion and supports the possibility that the skeletal dysmorphology seen in Dlx null mice may derive from abnormalities at the condensation stage. PMID: 15848386
    17. complex containing the Evf-2 ncRNA and the Dlx-2 protein forms in vivo, suggesting that the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity PMID: 16705037
    18. Dlx2 is required for coordinating programs of neurite maturation and migration. PMID: 17582329
    19. GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing lens: correlation with Dlx2 and Dlx5. PMID: 17969168
    20. DLX2 binds to a specific region of the TrkB promoter in retinal neuroepithelium during embryogenesis. PMID: 18086710
    21. Dlx2 acts potently neurogenic in adult lateral subependymal zone cells in vitro. PMID: 18562615

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 组织特异性：
    Expressed only in neural and other ectodermal structures of the head: the brain, the vomeronasal organ, and the preameloblasts of the teeth. Primarily expressed in the germinal cells of the ventral forebrain in the midgestational embryo, and in both dorsa
  • 数据库链接：

    KEGG: mmu:13392

    STRING: 10090.ENSMUSP00000024159

    UniGene: Mm.3896

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