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  4. Recombinant Mouse Histone deacetylase 9 (Hdac9)

Recombinant Mouse Histone deacetylase 9 (Hdac9)

  • 中文名称：
    小鼠Hdac9重组蛋白
  • 货号：
    CSB-YP010245MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hdac9重组蛋白
  • 货号：
    CSB-EP010245MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hdac9重组蛋白
  • 货号：
    CSB-EP010245MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hdac9重组蛋白
  • 货号：
    CSB-BP010245MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hdac9重组蛋白
  • 货号：
    CSB-MP010245MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hdac9
  • Uniprot No.：
    Q99N13
  • 别名：
    Hdac9; Hdac7b; Hdrp; Mitr; Histone deacetylase 9; HD9; EC 3.5.1.98; Histone deacetylase 7B; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-588
  • 氨基酸序列
    MHSMISSVDV KSEVPMGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL LLIQQQQQIQ KQLLIAEFQK QHENLTRQHQ AQLQEHIKEL LAIKQQQELL EKEQKLEQQR QEQEVERHRR EQQLPPLRGK DRGRERAVAS TEVKQKLQEF LLSKSATKDT PTNGKNHSVG RHPKLWYTAA HHTSLDQSSP PLSGTSPSYK YTLPGAQDSK DDFPLRKTAS EPNLKVRSRL KQKVAERRSS PLLRRKDGNL VTSFKKRVFE VAESSVSSSS PGSGPSSPNN GPAGNVTENE ASALPPTPHP EQLVPQQRIL IHEDSMNLLS LYTSPSLPNI TLGLPAVPSP LNASNSLKDK QKCETQMLRQ GVPLPSQYGS SIAASSSHVH VAMEGKPNSS HQALLQHLLL KEQMRQQKLL VAGGVPLHPQ SPLATKERIS PGIRGTHKLP RHRPLNRTQS APLPQSTLAQ LVIQQQHQQF LEKQKQYQQQ IHMNKLLSKS IEQLKQPGSH LEEAEEELQG DQSMEDRAAS KDNSARSDSS ACVEDTLGQV GAVKVKEEPV DSDEDAQIQE MECGEQAAFM QQVIGKDLAP GFVIKVII
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
  • 基因功能参考文献：
    1. HDAC9 may be involved in the process of diabetic nephropathy. PMID: 27633396
    2. decline in HDAC9c expression over time was accompanied by increased EZH2 expression. PMID: 27250566
    3. Xenograft study in nude mice showed that downregulation of HDAC9 inhibited tumor growth and development in vivo. PMID: 27033599
    4. Dach2 and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog and Gdf5 appear to stimulate muscle reinnervation through parallel pathways PMID: 26483211
    5. HDAC9 is a novel, important and physiologically relevant modulator of bone remodeling and skeletal homeostasis. PMID: 25793404
    6. Class IIa HDAC9 interact with Class IIb HDAC6 to modulate cell movement and survival in GnRH neurons PMID: 25873389
    7. Compared with HDAC9(+/+)ApoE(-/-) mice, HDAC9(-/-)ApoE(-/-) mice exhibited markedly reduced lesion sizes throughout atherosclerotic aortas and significantly less advanced lesions. PMID: 25388417
    8. HDAC9 deletion decreased atherosclerosis in LDLr(-/-) mice with minimal effect on plasma lipids. Macrophage HDAC9 upregulation is atherogenic via suppression of cholesterol efflux and generation of alternatively activated macrophages in atherosclerosis. PMID: 25035344
    9. Genetic ablation of HDAC9 improves adipogenic differentiation and systemic metabolic state during a high-fat diet, resulting in diminished weight gain, improved glucose tolerance and insulin sensitivity, and reduced hepatosteatosis. PMID: 24101673
    10. Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases HDAC4, 5 and 9 PMID: 23297420
    11. HDAC9 promotes angiogenesis and transcriptionally represses the endothelial cell miR-17-92 cluster. PMID: 23288173
    12. HDAC9 is responsible for repressing ChAT gene expression in NG108-15 neuronal cells and thus plays an important role in cholinergic differentiation. PMID: 22226696
    13. Data indicate that although histone deacetylases HDAC6, HDAC9, and Sirt1 all deacetylated Foxp3, each protein had different effects on transcription factors that control expression of the gene encoding Foxp3. PMID: 22715468
    14. investigation of role of class IIa HDAC isoenzymes in pancreas development: Data suggest HDAC4, -5, and -9 are key regulators controlling the pancreatic beta-/delta-cell lineage. PMID: 21953612
    15. HDAC9 acts as an epigenetic switch in effector T cell-mediated systemic autoimmunity. PMID: 21708950
    16. findings provide new insights into mechanisms of adipogenic differentiation and document a critical regulatory role for HDAC9 in adipogenic differentiation through a deacetylase-independent mechanism PMID: 21680747
    17. findings indicate that chromatin remodeling with nucleocytoplasmic translocation of HDAC9 regulates activity-dependent gene expression and dendritic growth in developing cortical neurons PMID: 20525066
    18. Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. PMID: 19879272
    19. MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase PMID: 12242305
    20. These results suggest that JMJ represses alphaMHC expression via protein-protein interaction with MEF2A. PMID: 15737621
    21. The transcriptional repressor HDAC9 forms a negative-feedback loop in the transcriptional circuitry of muscle differentiation. PMID: 17101791
    22. HDRP acts as a negative regulator of the Shh pathway and the absence of HDRP results in hyper-activation of this pathway resulting in polydactyly PMID: 18480421
    23. HDAC4, HDAC5, HDAC7 and HDAC9 were found associated with cardiac development. PMID: 19412888

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 组织特异性：
    Expressed at high levels in heart, brain and spleen. Expressed in skeletal muscle.
  • 数据库链接：

    KEGG: mmu:79221

    STRING: 10090.ENSMUSP00000106443

    UniGene: Mm.310551

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