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  4. Recombinant Mouse Histone deacetylase 7 (Hdac7), partial

Recombinant Mouse Histone deacetylase 7 (Hdac7), partial

  • 中文名称：
    小鼠Hdac7重组蛋白
  • 货号：
    CSB-YP010243MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hdac7重组蛋白
  • 货号：
    CSB-EP010243MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hdac7重组蛋白
  • 货号：
    CSB-EP010243MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hdac7重组蛋白
  • 货号：
    CSB-BP010243MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hdac7重组蛋白
  • 货号：
    CSB-MP010243MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hdac7
  • Uniprot No.：
    Q8C2B3
  • 别名：
    Hdac7; Hdac7a; Histone deacetylase 7; HD7; EC 3.5.1.98; Histone deacetylase 7A; HD7a
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response.
  • 基因功能参考文献：
    1. HDAC7 is a bona fide transcriptional repressor essential for B cell development. PMID: 27810920
    2. In the dorsal hippocampus, HDAC7 expression is decreased following contextual fear conditioning. PMID: 28283560
    3. This study demonstrated that hdac7 decrease in skeletal muscle in muscle atrophy. PMID: 26372908
    4. HDAC7 in osteoclasts is an important molecular regulator of MITF activity and bone homeostasis. PMID: 25875108
    5. Hdac7 degradation enhances beta-catenin transcriptional activity in growth plate chondrocytes. PMID: 25389289
    6. In hepatic stellate cells, CYLD removed HDAC7 from the hepatocyte growth factor promoter and induced HGF expression. PMID: 24811579
    7. HDAC7 overexpression suppresses, whereas HDAC7 deletion enhances, osteoclastogenesis PMID: 23204328
    8. Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance PMID: 23103766
    9. Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear beta-catenin translocation. PMID: 21836063
    10. Data suggest that HDAC7 nuclear export governs a self-sustaining autoexcitatory loop. PMID: 21398603
    11. Data indicate that CTLs had high expression of the histone deacetylase HDAC7 but continually phosphorylated and exported this transcriptional repressor from the nucleus. PMID: 21399638
    12. HDAC7 is a neuroprotective protein acting by a mechanism that is independent of its deacetylase activity but involving the inhibition of c-jun expression. PMID: 21118817
    13. Sp1 plays an important role in the regulation of Hdac7 gene expression in SMC differentiation from ES cells PMID: 20889501
    14. Results provide novel insight into the mechanisms that regulate myocyte differentiation and migration by controlling the subcellular distribution of HDAC7 in differentiating myoblasts. PMID: 20621129
    15. Hdac7 maintains vascular integrity by repressing MMP-10. PMID: 16873063
    16. These results strongly suggest that CRM1 mediated-nuclear export of HDAC7 is independent of HDAC7 phosphorylation and its association with 14-3-3s. PMID: 16956611
    17. Myosin phosphatase dephosphorylates HDAC7 and promotes its nuclear localization, leading to the repression of the HDAC7 target, Nur77, and the inhibition of apoptosis in CD4+CD8+ thymocytes. PMID: 17369396
    18. The expression of distinct HDAC7 mutants or the abrogation of HDAC7 expression can either enhance or inhibit the signal-dependent differentiation of a CD4(+)/CD8(+) cell line. PMID: 17470548
    19. HDAC7 undergoes alternative splicing during ES cell differentiation. HDAC7 splicing is important for SMC differentiation and vessel formation in embryonic development PMID: 19174469
    20. HDAC4, HDAC5, HDAC7 and HDAC9 were found associated with cardiac development. PMID: 19412888
    21. the beneficial effects of HDAC inhibitors are not predominantly mediated through the inhibition of HDAC7 PMID: 19484127

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 组织特异性：
    Highly expressed in heart and lung. Expressed at intermediate level in muscle.
  • 数据库链接：

    KEGG: mmu:56233

    STRING: 10090.ENSMUSP00000112110

    UniGene: Mm.384027

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