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  4. Recombinant Mouse Histone deacetylase 6 (Hdac6), partial

Recombinant Mouse Histone deacetylase 6 (Hdac6), partial

  • 中文名称：
    小鼠Hdac6重组蛋白
  • 货号：
    CSB-YP010242MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hdac6重组蛋白
  • 货号：
    CSB-EP010242MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hdac6重组蛋白
  • 货号：
    CSB-EP010242MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hdac6重组蛋白
  • 货号：
    CSB-BP010242MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hdac6重组蛋白
  • 货号：
    CSB-MP010242MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hdac6
  • Uniprot No.：
    Q9Z2V5
  • 别名：
    Hdac6; Histone deacetylase 6; HD6; EC 3.5.1.98; Histone deacetylase mHDA2; Tubulin-lysine deacetylase HDAC6; EC 3.5.1.-
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
  • 基因功能参考文献：
    1. These findings suggested that HDAC6 contributes to mitochondrial thermogenesis in brown adipose tissue by increasing UCP1 expression through cAMP-PKA signaling pathway. PMID: 29890133
    2. overexpression of Hdac6 extends reproductive lifespan in mice PMID: 28251586
    3. Hdac6-/- mice display low serum levels of inflammatory cytokine IL-6 and correspondingly an increased survival to a systemic infection with Listeria monocytogenes. The impaired bacterial clearance in the absence of HDAC6 appears to be caused by a defect in autophagy. PMID: 29281743
    4. deletion or inhibition of the cytoplasmic shuttling factor HDAC6 suppressed neuritic tau bead formation in neurons. PMID: 28854366
    5. HDAC6 inhibition and the regulation of Prx1 activity may play a significant role in protecting retinal cells and in particular photoreceptors. PMID: 29048427
    6. Results link the aberrant GlyRS-HDAC6 interaction to Charcot-Marie-Tooth disease type 2D pathology and suggest HDAC6 as an effective therapeutic target. PMID: 29520015
    7. 3T3-L1 cells treated with the siRNA against HDAC6 reduced the autophagy level and enhanced collagen-induced cilia elongation, implying that HDAC6 was involved in mediating autophagy PMID: 28811097
    8. identified that class II histone deacetylase 6 deacetylates and subsequently activates mDia2. PMID: 28255013
    9. Study demonstrated that global Hdac6 knock-out mice show dopaminergic abnormalities. The behavioral and pharmacological analysis revealed that Hdac6 gene ablation results in an increased response of postsynaptic D2R. PMID: 27544826
    10. Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 axis and suggest a functional interplay between these two proteins in ciliary homeostasis. PMID: 27028867
    11. Suppression of HDAC6 enhanced the interaction between HIF-1alpha and HSP70 under hypoxic conditions. PMID: 28116619
    12. Overall, our results provide the first evidence that HDAC6 is capable of inducing expression of pro-inflammatory genes by regulating the ROS-MAPK-NF-kappaB/AP-1 pathways and serves as a molecular target for inflammation. PMID: 27208785
    13. MAP3K4 activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6. PMID: 28273454
    14. HDAC6 is a critical regulator of a pro-apoptotic p53 K120 acetylation and mitochondrial function in mesenchymal stem cells PMID: 29054408
    15. HDAC6 inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2+) levels. PMID: 28887310
    16. These data thus reveal that HDAC6 represses IL-17 production in T cells, providing novel insights into the role of HDAC6 in the immune system. PMID: 28382171
    17. A decrease of HDAC6 expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer. PMID: 28700998
    18. HDAC6 inhibition reduces tumor growth and PD-L1 production in vivo. PMID: 26775640
    19. Specific HDAC6 inhibitor, tubacin, reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP levels, and improved renal function in mouse model of autosomal dominant polycystic kidney disease (ADPKD). Thus, HDAC6 could play a role in cyst formation and could serve as a potential therapeutic target in ADPKD. PMID: 27165822
    20. Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by Hdac6 (histone deacetylase 6 protein). PMID: 28760828
    21. ARID1A mutation inactivates the apoptosis-promoting function of p53 by upregulating HDAC6, indicating that pharmacological inhibition of HDAC6 is a therapeutic strategy for ARID1A-mutated cancers. PMID: 28737768
    22. findings showed that CAMDI regulates neuronal migration through the modulation of HDAC6 and indicate that HDAC6 hyperactivation by CAMDI deletion causes psychiatric behaviors, at least in part, through delayed radial migration due to impaired centrosomes PMID: 27737934
    23. HDAC6 contributes to the pathogenesis of rhabdomyolysis-induced acute kidney injury. PMID: 28052874
    24. In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt and activated glycogen synthase kinase (GSK)-3beta. PMID: 26452072
    25. HDAC6 may represent an optimal target for future immunosuppressant therapeutics with a particular role in transplantation. PMID: 27222932
    26. Further PS treatment resulted in recovery of axonal outgrowth and enhanced retrograde axonal transport by decreasing histone deacetylase 6 (HDAC6) levels and thus increasing acetylation of alpha-tubulin levels. Thus, we have identified the molecular pathway that leads to neurodegeneration in FD and have demonstrated that phosphatidylserine treatment has the potential to slow progression of neurodegeneration PMID: 27997532
    27. HDAC6-mediated autophagy negatively regulates primary cilia length during silibinin treatment and has the potential to serve as a therapeutic target for primary cilia-associated ciliopathies. PMID: 27435857
    28. HDAC6 is an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by cytotoxic T lymphocytes. PMID: 26869226
    29. It protects neurons from toxicity of prion peptide, and that this protection occurs at through the regulation of the PI3k-Akt-mTOR axis. PMID: 26507311
    30. mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6. PMID: 26581825
    31. We therefore tested that reducing HDAC6 levels by genetic manipulation would attenuate early cognitive and behavioral deficits in R6/1 mice PMID: 26445700
    32. HDAC6 plays an important role in the function of CMA pathway under the HI stress induced by SCI and it may be a potential therapeutic target in acute SCI model. PMID: 26649145
    33. functional loss or suppression of the tumor suppressor HDAC6 is caused by induction of miR-221 through coordinated JNK/c-Jun- and NF-kappaB-signaling pathways during liver tumorigenesis PMID: 25817558
    34. Hyperacetylation of Hsp90 is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 inhibitors increase Hsp90 acetylation and modulate GR chaperone dynamics. PMID: 25442004
    35. This study demonstrated that hdac6 increase in skeletal muscle in muscle atrophy. PMID: 26372908
    36. Results indicate that Histone deacetylase 6 has neuroprotective effects in an animal model of amyotrophic lateral sclerosis. PMID: 26164555
    37. Our results indicate that HDAC6 is a critical regulator of MFN2 degradation by MARCH5, thus protecting mitochondrial connectivity from hypoxic stress. PMID: 26210454
    38. An important role for HDAC6 in regulating the mammalian Hh pathway. PMID: 25552369
    39. results indicate that HDAC6 negatively regulates NLRP3 inflammasome activation through its interaction to ubiquitinated NLRP3 PMID: 26471297
    40. These data thus suggest that HDAC6 is an important regulator of LPS-induced macrophage activation and might be a potential target for the management of inflammatory disorders. PMID: 25330030
    41. The Hdac6 tg mice reported in this study provide the proof of principle of anti-virus function by Hdac6 in vivo PMID: 25482409
    42. Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6) is a key determinant of cilium size in growth-arrested cells via HDAC6 activation and HDAC6 subcellular distribution. PMID: 24667272
    43. In cells expressing HDAC6 mutated in the ubiquitin-binding domain, the AAA ATPase factor p97/VCP mediates rapid inactivation of HSF1. PMID: 25298398
    44. The major finding of the study is that HDAC6 is a regulatory target for the specific lineage commitment of embryonic stem cells. PMID: 25662604
    45. It appears as a key modulator of cell protective response to the cytotoxic a-syn aggregates. PMID: 24866403
    46. HDAC6 is not required for ROS-dependent ER stress-induced apoptosis of nasopharyngeal carcinoma cells PMID: 24771510
    47. HDAC6 forms a previously unknown molecular complex with STAT3, association that was detected in both the cytoplasmic and nuclear compartments of the antigen presenting cells PMID: 25108026
    48. Suggest that HDAC6 plays a role in angiotensin II-induced heart failure, and associated skeletal muscle wasting. PMID: 24858848
    49. HDAC6, primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 as a transcriptional activator. PMID: 24747960
    50. Sept7 provides a physical scaffold for HDAC6 to achieve efficient microtubule deacetylation, thereby negatively regulating microtubule stability to an optimal level for neuritogenesis. PMID: 24113571

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, axon.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 组织特异性：
    Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level).
  • 数据库链接：

    KEGG: mmu:15185

    STRING: 10090.ENSMUSP00000033501

    UniGene: Mm.29854

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