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  4. Recombinant Mouse Histone deacetylase 4 (Hdac4), partial

Recombinant Mouse Histone deacetylase 4 (Hdac4), partial

  • 中文名称：
    小鼠Hdac4重组蛋白
  • 货号：
    CSB-YP010240MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hdac4重组蛋白
  • 货号：
    CSB-EP010240MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hdac4重组蛋白
  • 货号：
    CSB-EP010240MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hdac4重组蛋白
  • 货号：
    CSB-BP010240MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hdac4重组蛋白
  • 货号：
    CSB-MP010240MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hdac4
  • Uniprot No.：
    Q6NZM9
  • 别名：
    Hdac4; Histone deacetylase 4; HD4; EC 3.5.1.98
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
  • 基因功能参考文献：
    1. intracellular trafficking of HDAC4 contributes to the vulnerability of cells expressing pathogenic alpha-synuclein mutants. PMID: 27785754
    2. Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKalpha2-dependent manner. PMID: 28688716
    3. HDAC4 stimulates MRTF-A expression and drives fibrogenesis in hepatic stellate cells by targeting miR-206 PMID: 28548935
    4. The cytoplasmic location and function of HDAC4 is controlled by the activity of salt-inducible kinase (SIK). These results establish a cytoplasmic role for HDAC4 and identify HDAC4, SIK, and ENIGMA as mediators of vascular calcification. PMID: 28588072
    5. CaMKIV is a key regulator of neuronal intracellular HDAC4 trafficking during stroke PMID: 26969532
    6. This study suggested that HDAC4-induced transcriptional inactivation of CREB is responsible for isoflurane-induced cognitive dysfunction in the brain. PMID: 27544482
    7. the phenotype seen in the Hdac4(-/-) mice is partially derived from elevation in MMP-13 and may be due to a bone remodeling disorder caused by overexpression of this enzyme. PMID: 27320207
    8. beige adipocyte renaissance was governed by liver kinase b1 and histone deacetylase 4 in white adipocytes. PMID: 28882900
    9. class IIa HDAC function could be used to enhance metabolic health in chronic diseases driven by physical inactivity. PMID: 27626651
    10. Results show that HDAC4 inhibits myogenic differentiation and promoted C2C12 cell proliferation. Its expression is under the regulation of mir-378a which targets its promotor region. PMID: 27661135
    11. our results imply that under steady stage, HDAC4 is not required for the development and function of multiple T cell lineages PMID: 28177888
    12. HDAC4-mediated SUMOylation of the corepressor DACH1 is decreased, which protects DACH1 from proteasomal degradation PMID: 27239042
    13. The eating-disorder (ED) associated HDAC4(A778T) mutation alters feeding behaviors in female mice. The HDAC4(A778T) mouse line is a novel model of ED-related behaviors and identifies mitochondrial biogenesis as a potential molecular pathway contributing to behavioral deficits. PMID: 27884425
    14. Nuclear HDAC4 binds to chromatin as well as to MEF2A transcription factor, leading to histone deacetylation and altered neuronal gene expression. By using a Cdkl5 knockout (Cdkl5 -/Y) mouse model, we found that hypophosphorylated HDAC4 translocates to the nucleus of neural precursor cells, thereby reducing histone 3 acetylation. PMID: 27466189
    15. Data (including data from studies using knockout mice) suggest that S100A1 (S-100 calcium-binding protein A1, alpha chain) is involved in protein kinase A- (RIIalpha and RIIbeta)-dependent signaling resulting in nuclear redistribution/influx of HDAC4 (histone deacetylase 4) in skeletal muscle fibers. PMID: 28409622
    16. results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 degradation. PMID: 27875543
    17. PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells. PMID: 27333946
    18. postmitotic expression SOD1G93A mutant gene promotes a FAPS phenotype in C2C12 cells, by upregulating HDAC4 protein and preventing the BAF60C-SWI/SNF complex myogenic commitment PMID: 26491230
    19. miR-29a was involved in the regulation of HDAC4 and modulation of the profibrogenic phenotype in hepatic stellate cells. PMID: 26305546
    20. This study demonstrated that hdac4 increase in skeletal muscle in muscle atrophy. PMID: 26372908
    21. These results demonstrate that miR-140 ensures the robustness of the PTHrP/HDAC4 regulatory system by suppressing MEF2C-inducing stimuli. PMID: 25529628
    22. The data of this study demonstrated pronounced and distinctively different changes in the expression of class IV HDAC in subfields of the hippocampus after an acute status epilepticus, during epileptogenesis and in chronic TLE. PMID: 26238735
    23. Phosphorylation and localization of HDAC4 contributes to establishing fiber type-specific transcriptional programs. PMID: 25728750
    24. HDAC4 is a novel inflammatory pain mediator. PMID: 25903105
    25. Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. PMID: 25187650
    26. HDAC4 is a novel regulator of Pax7-dependent satellite cell proliferation. PMID: 25205686
    27. Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. PMID: 24717296
    28. As variants in the Hdac4 gene are associated with obesity in humans, the results indicate that the cAMP-HDAC4 pathway functions importantly in maintaining insulin sensitivity and energy balance via its effects on the innate immune system. PMID: 24768298
    29. the ratjadone C-mediated nuclear retention assay can potentially be used as a screening tool to identify novel regulatory mechanisms of HDAC4 and its functional partners in various pathophysiological conditions. PMID: 25854767
    30. p38 promotes HDAC4 degradation by increasing caspase-mediated cleavage. PMID: 25447540
    31. the cross talk between HDAC4 and STAT6 is an important regulatory mechanism of Arg1 transcription in dendritic cells PMID: 25332236
    32. data suggest that basal, but not evoked, N-MethylD-apartate Receptor activity regulates gene expression in part through Histone Deacetylase 4, and, that HDAC4 has neuroprotective functions under conditions of low NMDAR activity. PMID: 25392500
    33. The absence of HDAC4 had no effect on the acetylation profile of the murine neonate brain. PMID: 24278330
    34. Data show that HDAC4 plays global roles in the regulation of gene transcription, cell growth, survival and proliferation, and their aberrant expression or activity leads to cancer development. PMID: 24579951
    35. HDAC4 inhibition promotes cardiac progenitor cell-derived cardiac regeneration and improves the restoration of cardiac function in myocardial infarction. PMID: 24944198
    36. HDAC4 is a critical regulator of osteoclast differentiation. PMID: 24934156
    37. HDAC4 reduction delays cytoplasmic aggregate formation, restores bdnf transcript levels, and rescues neuronal and cortico-striatal synaptic function in Huntington's disease mouse models. PMID: 24302884
    38. a context-dependent role of miR-206 in regulating hypertrophy PMID: 24023888
    39. We examined whether HDAC4 controls vascular smooth muscle cell proliferation and migration. PMID: 24166750
    40. Protein kinase A and CaMKII pathways play important opposing roles in skeletal muscle gene expression by oppositely affecting the subcellular localization of HDAC4. PMID: 23652597
    41. Activation of MEF2 reverses the oncogenic properties of cells expressing HDAC4. PMID: 24043307
    42. these results identify HDAC4 as an important regulator of Gadd45a in denervation-induced muscle atrophy and elucidate Gadd45a as a convergence point for distinct upstream regulators during muscle denervation and fasting. PMID: 23941879
    43. Neurons are less dependent on HDAC4 expression for their survival; neuronal death in HDAC4 knockout mice may be from HDAC4 deficiency in nonneural cells. PMID: 23239283
    44. HDAC4 oxidation decreased in cardiac-specific Nox4 knockout mice 2 weeks after transverse aortic constriction. Nox4 knockdown attenuated O(2)(-) production in the nucleus & prevented phenylephrine-induced oxidation & nuclear exit of HDAC4. PMID: 23271793
    45. CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A. PMID: 23151343
    46. Long-lasting stress-inducible changes in AChE's promoter choices, identify the chromatin changes that support this long-term transcriptional memory, and reveal HDAC4 as a mediator of these effects in the hippocampus. PMID: 23236169
    47. HDAC4, a histone deacetylase that shuttles between the nucleus and cytoplasm, controls a transcriptional program essential for synaptic plasticity and memory. PMID: 23141539
    48. The data showed that the reactive oxygen species generated by NOX2 play important roles in muscle remodeling due to intense muscle activity and that the nuclear effluxes of HDAC4 and HDAC5 are differentially regulated by Ca2+ and reactive oxygen species. PMID: 22648949
    49. Data show that HDAC4 binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2. PMID: 22658415
    50. The resuklts of this study suggested that HDAC4 is a crucial positive regulator of learning and memory, both behaviorally and at the cellular level, and that inhibition of Hdac4 activity may have unexpected detrimental effects to these processes. PMID: 22875922

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 数据库链接：

    KEGG: mmu:208727

    STRING: 10090.ENSMUSP00000008995

    UniGene: Mm.318567

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