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  4. Recombinant Mouse Hepatocyte nuclear factor 3-gamma (Foxa3)

Recombinant Mouse Hepatocyte nuclear factor 3-gamma (Foxa3)

  • 中文名称：
    小鼠Foxa3重组蛋白
  • 货号：
    CSB-YP008796MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Foxa3重组蛋白
  • 货号：
    CSB-EP008796MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Foxa3重组蛋白
  • 货号：
    CSB-EP008796MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Foxa3重组蛋白
  • 货号：
    CSB-BP008796MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Foxa3重组蛋白
  • 货号：
    CSB-MP008796MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxa3
  • Uniprot No.：
    P35584
  • 别名：
    Foxa3; Hnf3g; Tcf-3g; Tcf3gHepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; Forkhead box protein A3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-353
  • 氨基酸序列
    MLGSVKMEAH DLAEWSYYPE AGEVYSPVNP VPTMAPLNSY MTLNPLSSPY PPGGLQASPL PTGPLAPPAP TAPLGPTFPS LGTGGSTGGS ASGYVAPGPG LVHGKEMAKG YRRPLAHAKP PYSYISLITM AIQQAPGKML TLSEIYQWIM DLFPYYRENQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWALHPSSG NMFENGCYLR RQKRFKLEEK AKKGNSATSA SRNGTAGSAT SATTTAATAV TSPAQPQPTP SEPEAQSGDD VGGLDCASPP SSTPYFSGLE LPGELKLDAP YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL NAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility.
  • 基因功能参考文献：
    1. FOXA3 is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells. PMID: 28379539
    2. These findings reveal an obligatory coregulatory role of Foxa3 in the regulation of ER-alpha expression and of the Foxa3/ER-alpha cascade, at least in part, in the pathogenesis of androgen deficiency caused by type 2 diabetes mellitus. PMID: 28645613
    3. These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells. PMID: 27107701
    4. studies provide the first demonstration, to our knowledge, that Foxa3 is a direct target of GC action in adipose tissues and point to a role of Foxa3 as a mediator of the side effects induced in fat tissues by chronic treatment with synthetic steroids PMID: 26957608
    5. transcription factor Foxa3 was a strong promoter of liver regeneration. PMID: 25934503
    6. during aging, Foxa3 is up-regulated in brown and inguinal white fat depots, and midage Foxa3-null mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion, improved insulin sensitivity, and increased longevity PMID: 25225406
    7. Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease. PMID: 24392884
    8. Foxa3 promotes adipocyte differentiation by cooperating with C/EBP beta and - delta to transcriptionally induce PPAR gamma expression. PMID: 23798556
    9. these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels. PMID: 22586590
    10. FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program PMID: 22595668
    11. Intraovarian excess androgen in polycystic ovary syndrome may result in excess follicles by inducind Foxo 3a translocation. PMID: 20032061
    12. binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. PMID: 12000309
    13. Foxa3 is a transcriptional regulator with a dominant phenotype in germ cell maintenance PMID: 17488644
    14. Unlike FOXA2, FOXA3 did not regulate mucous metaplasia in allergic airway disease and asthma. PMID: 19628779

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine), also present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.
  • 数据库链接：

    KEGG: mmu:15377

    STRING: 10090.ENSMUSP00000043173

    UniGene: Mm.42260

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