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  4. Recombinant Mouse Hepatocyte nuclear factor 1-beta (Hnf1b)

Recombinant Mouse Hepatocyte nuclear factor 1-beta (Hnf1b)

  • 中文名称：
    小鼠Hnf1b重组蛋白
  • 货号：
    CSB-YP010593MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hnf1b重组蛋白
  • 货号：
    CSB-EP010593MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hnf1b重组蛋白
  • 货号：
    CSB-EP010593MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hnf1b重组蛋白
  • 货号：
    CSB-BP010593MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hnf1b重组蛋白
  • 货号：
    CSB-MP010593MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hnf1b
  • Uniprot No.：
    P27889
  • 别名：
    Hnf1b; Hnf-1b; Tcf2; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-558
  • 氨基酸序列
    MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP GSGADLDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQNQGPGQSE DTCSEPTNKK MRRNRFKWGP ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF ANRRKEEAFR QKLAMDAYSS NQTHNLNPLL THGSPHHQPS SSPPNKMSGV RYNQPGNNEV TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHSLLSPDS KMQITVSGGG LPPVSTLTNI HSLSHHNPQQ SQNLIMTPLS GVMAIAQSLN TSQAQGVPVI NSVASSLAAL QPVQFSQQLH SPHQQPLMQQ SPGSHMAQQP FMAAVTQLQN SHMYAHKQEP PQYSHTSRFP SAMVVTDTSS INTLTSMSSS KQCPLQAW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1.
  • 基因功能参考文献：
    1. Loss of HNF1B in renal epithelial cells Results in Kidney Disease with Cysts. PMID: 29735694
    2. HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16.Thus, HNF1beta is a transcriptional activator of Kcnj16. PMID: 28577853
    3. Results provide evidence that downregulation of HNF1b and activation of reactive oxygen species/NF-kappaB-mediated in fl ammation play an important role in PCB-153-induced glucose/lipid metabolic disorder. PMID: 28285191
    4. Hnf1b deletion leads to massively mispatterned ureteric tree network, defective collecting duct differentiation and disrupted tissue architecture, which leads to cystogenesis. This study uncovers a fundamental and recurring role of HNF1B in epithelial organization during early ureteric bud branching and in further patterning and differentiation of the collecting duct system in mouse. PMID: 29158444
    5. This review discusses the role of HNF1B in human and murine pancreas and liver development, summarizes the disease phenotypes and identifies areas for future investigations in HNF1B-associated diabetes and liver disease. [Review Article] PMID: 27615128
    6. role in osmoregulation in renal collecting ducts PMID: 28507058
    7. These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells. PMID: 27107701
    8. HNF-1beta Regulates MicroRNA-200 Expression through a Long Noncoding RNA PMID: 26292219
    9. TNFalpha regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin. PMID: 25503683
    10. Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha. PMID: 23704921
    11. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta. PMID: 23657850
    12. HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. PMID: 23362348
    13. Hepatocyte nuclear factor 1beta controls nephron tubular development. PMID: 23362349
    14. identification of Hnf1b as a target of miR-802-dependent silencing; show that short hairpin RNA (shRNA)-mediated reduction of Hnf1b in liver causes glucose intolerance, impairs insulin signalling and promotes hepatic gluconeogenesis PMID: 23389544
    15. Hnf1b and Pax2 operate to control kidney morphogenesis and ureter differentiation. PMID: 22511595
    16. Overexpression of HNF1beta resulted in accelerated cell proliferation with the protein level up-regulation of plasminogen and plasmin, a converted active form of plasminogen, which play a pivotal role in liver regeneration inducing hepatocyte proliferation. PMID: 21385055
    17. Study identifies new direct target genes of the Hnf1b transcription factors and shows that they play crucial roles in both defining cell fate and controlling terminal functions in the gut epithelium. PMID: 20388655
    18. transcriptional hierarchy between HNF-1beta and PKD (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested, and collectrin is one of such HNF-1beta regulated genes PMID: 17476336
    19. inactivation does not elicit cystic dilation in cystic tubules after their proliferative morphogenetic elongation is complete, giving rise to cysts PMID: 19966811
    20. The results demonstrate that vHNF1 plays a crucial role during the earliest stages of urogenital development and provide novel insights into the regulatory circuits controlling events. PMID: 20040500
    21. These data suggest a requirement for HNF1beta in biliary epithelium formation from the onset of the biliary system development. PMID: 11934849
    22. mutations of HNF-1beta may cause dysregulated ksp-cadherin promoter activity PMID: 12217876
    23. pathogenic consequences of mutations within the HNF-1 beta gene by mRNA analysis. PMID: 15085338
    24. HNF1beta is involved in regulating the beta-cell transcription factor network and is necessary for glucose sensing or glycolytic signaling. PMID: 15142986
    25. Expression profile analysis with mouse cDNA microarrays detected 243 genes whose expression levels were decreased by >50% upon RNAi of HNF-1beta PMID: 15148361
    26. the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain has a role in Pkhd1 (ARPKD) gene transcription and renal cystogenesis PMID: 15647252
    27. Lack of TCF2 results in pancreas agenesis by embryonic day 13.5. PMID: 15668393
    28. The largest series to date of HNF-1beta mutations and confirm HNF-1beta mutations as an important cause of renal disease. PMID: 15930087
    29. These results suggest that expression of Hnf6 and Hnf1b is downstream of C/EBPalpha action in fetal liver development, and that the suppression of C/EBPalpha expression in periportal hepatoblasts may lead to expression of Hnf6 and Hnf1b mRNAs. PMID: 17021047
    30. MAFB, which is itself regulated by vHNF1, acts as a positive modulator of vHnf1 in r5 and r6, whereas another MAF-related factor is absolutely required for the expression of vHnf1 in both the hindbrain and the spinal cord. PMID: 17669392
    31. The expression of Hfn1b protein in the developing pancreas is reported. PMID: 17996499
    32. Overexpression of HNF1beta along with HNF1alpha enhances the activity of OAT1 promoters. PMID: 18029548
    33. HNF-1beta regulates tubulogenesis by controlling the levels of SOCS-3 expression. PMID: 18077349
    34. vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification. PMID: 18635606
    35. Renal transcription factors HNF1alpha, HNF1beta, and HIF-1 might be the central mediators of drug-induced kidney injury and adaptive response pathways. PMID: 18656965
    36. HNF-1beta regulates transcription of the PKD modifier gene Kif12. PMID: 19005009

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HNF1 homeobox family
  • 数据库链接：

    KEGG: mmu:21410

    STRING: 10090.ENSMUSP00000021016

    UniGene: Mm.7226

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