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  4. Recombinant Mouse Heme oxygenase 2 (Hmox2)

Recombinant Mouse Heme oxygenase 2 (Hmox2)

  • 中文名称：
    小鼠Hmox2重组蛋白
  • 货号：
    CSB-YP010584MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hmox2重组蛋白
  • 货号：
    CSB-EP010584MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hmox2重组蛋白
  • 货号：
    CSB-EP010584MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hmox2重组蛋白
  • 货号：
    CSB-BP010584MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hmox2重组蛋白
  • 货号：
    CSB-MP010584MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hmox2
  • Uniprot No.：
    O70252
  • 别名：
    Hmox2; Heme oxygenase 2; HO-2; EC 1.14.14.18
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-315
  • 氨基酸序列
    SSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT QFVKDFLKGN IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT ELHRKAALIK DMKYFFGENW EEQVKCSEAA QKYVDRIHYV GQNEPELLVA HAYTRYMGDL SGGQVLKKVA QRALKLPSTG EGTQFYLFEH VDNAQQFKQF YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG SMLARETLED GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA ASVALVAGLL AWYYM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
  • 基因功能参考文献：
    1. This study demonstrated that HO-2 is involved in reducing inflammatory responses mediated by macrophages. Downstream factors (TNF-alpha, IL1beta and IL-6) that play a role in the TLR4 signaling pathway were suppressed in HO-2 overexpressing macrophages. HO-2 enhanced the survival of allografted skin. PMID: 30099287
    2. Decreased oxygen consumption and increased mitochondrial ROS production in response to hypoxia were dependent upon HO-2 expression. HO-2 expression regulated HIF-1alpha and JNK signaling in a mitochondrial ROS-dependent manner. PMID: 29849867
    3. This study demonstrated that Deletion of the heme oxygenase-2 aggravates brain injury following stroma-free hemoglobin-induced PMID: 26831741
    4. HO-2 shRNA and HO-2 overexpression plasmids were used to observe the effect of HO-2 in cerebral microvascular endothelial cells. mRNA and protein levels of TNF-alpha and IL6 were increased and decreased, respectively, compared with control groups. PMID: 24788682
    5. macrophage HO-2 is required for proper macrophage function but is insufficient to correct the impaired healing of the HO-2(-/-) cornea, suggesting that corneal epithelial expression of HO-2 is a key to resolution and repair in wound healing PMID: 25342128
    6. These results demonstrate a sex-specific effect of HO-2 deficiency on the development of renovascular hypertension and its effects on the heart in response to the increase in blood pressure. PMID: 23721883
    7. HO-2 critically contributes to the adequacy of arteriovenous fistula blood flow and function. PMID: 23678042
    8. protein-protein interactions between HO-2 and adiponectin highlight the role of HO-2 as a molecular chaperone for adiponectin assembly, while HO-1 increases adiponectin levels. PMID: 23438433
    9. PFKFB4 and HO-2 are expressed in a coordinated manner to maintain glucose homeostasis. PMID: 22892400
    10. ells other than neutrophils contribute to the exaggerated inflammation and impaired wound healing seen in the HO-2 null cornea PMID: 21695050
    11. deficiency in HO-2 alters both the kinetics of secondary damage and fine motor recovery after traumatic brain injuries. PMID: 20389079
    12. The the expression of HO-2 protein was increased in the sub-endocardial myocardium of ventricles under hypoxia, while HO-1 protein level was increased in the full-thickness walls. PMID: 19819905
    13. HO-2 expression protects neurons against TBI by reducing lipid peroxidation via the catabolism of free heme PMID: 12736340
    14. HO-2 mediates opioid tolerance, the expression of mechanical allodynia after opioid withdrawal, and in gene regulation occurring during treatment with morphine. PMID: 14580950
    15. HO-2 participates in the thermal hyperalgesia and mechanical allodynia that occur in 2 commonly used models of chronic inflammatory and neuropathic pain. PMID: 14622721
    16. physiologic effects of exogenous and endogenous VIP in the internal anal sphincter are mediated by HO2-synthesized CO. PMID: 14983060
    17. is involved in oxygen sensing and responsible for the ventilation-perfusion matching that optimizes oxygenation of pulmonary blood PMID: 15219859
    18. These results suggest that HO-2 gene deletion protects neurons in mixed neuron-astrocyte cultures from heme-mediated oxidative injury. PMID: 15377391
    19. Expression levels of HO-2 protein is transiently reduced in the liver at 7 days of hypoxia, and increased in the heart at 28 days. PMID: 16137650
    20. The results suggest that the deleterious action of nNOS would counteract the role of HO-2 in neuroprotection. PMID: 16181097
    21. HO-2 plays a major role in neuroprotection from oxidative stress, an effect that is mediated by cGMP and bilirubin. PMID: 16181104
    22. Highly present in wildtype animals and not detectable in HO-2 knockout mice. PMID: 16181109
    23. HO-2 activity is essential in preserving renal function and morphology in STZ-induced diabetic mice probably via mitigation of concomitant oxidative stress. PMID: 16524951
    24. role of heme oxygenase-2 as an oxygen sensor PMID: 16683713
    25. HO-2 is critical for protection of cerebrovascular endothelium against apoptotic changes induced by oxidative stress and cytokine-mediated inflammation. PMID: 16822952
    26. The data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K(+) channel gene expression but it does not alter the intrinsic O(2) sensitivity of carotid body or adrenal medulla cells. PMID: 16966473
    27. HO-2 sets in place a basal tone of anti-inflammatory signals that may be a prerequisite for the ordered execution of an inflammatory and reparative response. PMID: 17071585
    28. HO-2(-/-) mice, which fail to induce HO-1, have exacerbated inflammation in response to injury. The 12/15-LOX and HO systems function in concert to control inflammation. PMID: 17384141
    29. Suggest membrane potential gradient in small intestine is dependent on carbon monoxide generated by HO-2 in interstital cells of Cajal. PMID: 17510199
    30. Report the role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers. PMID: 18495834
    31. The results provide additional evidence that HO2 plays a critical protective role against ICH-induced early brain injury. PMID: 18674596
    32. is demonstrated that neither deletion of HO-2 nor BK channels affect acute, sustained, and chronic vascular responses to alveolar hypoxia in the lung. PMID: 19498059
    33. Blood pressure and renal blood flow responses to increased ANG II or inhibition of nitric oxide are not significantly enhanced in HO-2 KO mice. PMID: 19846746

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  • 亚细胞定位：
    Microsome. Endoplasmic reticulum.
  • 蛋白家族：
    Heme oxygenase family
  • 数据库链接：

    KEGG: mmu:15369

    STRING: 10090.ENSMUSP00000004172

    UniGene: Mm.272866

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