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  4. Recombinant Mouse Heart- and neural crest derivatives-expressed protein 1 (Hand1)

Recombinant Mouse Heart- and neural crest derivatives-expressed protein 1 (Hand1)

  • 中文名称：
    小鼠Hand1重组蛋白
  • 货号：
    CSB-YP727054MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hand1重组蛋白
  • 货号：
    CSB-EP727054MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hand1重组蛋白
  • 货号：
    CSB-EP727054MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hand1重组蛋白
  • 货号：
    CSB-BP727054MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hand1重组蛋白
  • 货号：
    CSB-MP727054MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hand1
  • Uniprot No.：
    Q64279
  • 别名：
    Hand1; Ehand; Hxt; Thing1; Heart- and neural crest derivatives-expressed protein 1; Extraembryonic tissues; heart; autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND; Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Thing-1; Th1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-216
  • 氨基酸序列
    MNLVGSYAHH HHHHHSHPPH PMLHEPFLFG PASRCHQERP YFQSWLLSPA DAAPDFPAGG PPPTTAVAAA AYGPDARPSQ SPGRLEALGS RLPKRKGSGP KKERRRTESI NSAFAELREC IPNVPADTKL SKIKTLRLAT SYIAYLMDVL AKDAQAGDPE AFKAELKKTD GGRESKRKRE LPQQPESFPP ASGPGEKRIK GRTGWPQQVW ALELNQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
  • 基因功能参考文献：
    1. Somatically acquired Hand1A126FS mutation is not causative of hypoplastic left heart syndrome PMID: 29016838
    2. a non-essential role for Hand1 in mouse limb morphogenesis, is reported. PMID: 28576769
    3. Surviving Hand1;Hand2 mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair. PMID: 28732025
    4. Within the pharyngeal arches, the distal-most of the proximo-distally oriented subdomains of cranial neural crest cells, the distal cap, is marked by expression of the transcription factor Hand1 and gives rise to the ectomesenchymal derivatives of the lower incisors. PMID: 27335460
    5. Data suggest the protection role of haploinsufficiency of heart and neural crest derivatives expressed transcript 1 protein (Hand1) after acute myocardial infarction (AMI). PMID: 27601324
    6. Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh. Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 transactivation of the Ihh proximal promoter. PMID: 26918743
    7. Re-expression of HAND1 in colon cancer cells induces terminal differentiation. PMID: 25032847
    8. Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis PMID: 25053435
    9. Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing H3K14ac in the fetal heart. PMID: 24857828
    10. Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption. PMID: 24086110
    11. that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo. PMID: 23911935
    12. Hand1-mediated activation of Tbeta4 is essential for yolk sac vasculogenesis and embryonic survival, and administration of synthetic TB4 partially rescues yolk sac capillary plexus formation in Hand1-null embryos. PMID: 20975697
    13. Data define a critical threshold of Hand1 expression that is necessary for embryonic survival. PMID: 20737509
    14. Results show that Hand1 regulates development of lateral mesoderm derivatives and its loss in extraembryonic mesoderm is the primary cause of lethality in Hand1-null embryos. PMID: 20506548
    15. Hand1-driven Cre marks specific lineages within the extra embryonic tissues, placenta, sympathetic nervous system, limbs, jaw, and several cell types within the cardiovascular system. PMID: 20882677
    16. expressed in the adult-rodent heart and is modulated during cardiac hypertrophy PMID: 12359233
    17. eHAND expression may be related to the anteroventral identity of the mesoderm. PMID: 12666206
    18. These data indicate that Hand1 is required for angiogenesis and vascular smooth muscle recruitment in the yolk sac. PMID: 15073150
    19. CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy PMID: 15172687
    20. Hand1 and Stra13 promote cell cycle exit and restrict cells towards the Trophoblast Giant cell fate. PMID: 15196947
    21. Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription PMID: 15576406
    22. MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
    23. increased transcriptional activity of Hand1 caused by Sox15 might promote the transcription of the target gene resulting in the trophoblast giant cell differentiation in the mouse placenta PMID: 16759287
    24. Hand1 is a crucial cardiac regulatory protein that controls the balance between proliferation and differentiation in the developing heart. PMID: 17050624
    25. the importance of Hand1 transcription factor in the transcriptional circuitry of craniofacial and tooth development PMID: 17764670
    26. Study shows nucleolar sequestration of Hand1 accompanies sustained cell proliferation and renewal, whereas release of Hand1 into the nucleus leads to its activation, thus committing cells to a differentiated giant-cell fate. PMID: 17891141
    27. Hand1 is expressed in apical cells lining maternal blood spaces. PMID: 18448564
    28. Expression of HAND1 is maintained in sympathetic neurons throughout fetal and postnatal development when these neurons depend on nerve growth factor for survival. PMID: 18724272
    29. HMGA1 proteins bind directly to Hand1 promoter both in vitro and in vivo and inhibit Hand1 promoter activity PMID: 19060921
    30. Overexpression of Hand1 in the adult mouse heart leads to mild cardiac hypertrophy and a reduction in life expectancy. elevated HAND1 may provide one of the molecular links between the failing heart and arrhythmia. PMID: 19376125

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  • 亚细胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.
  • 组织特异性：
    Smooth muscle cells of the gut and adrenal tissue.
  • 数据库链接：

    KEGG: mmu:15110

    STRING: 10090.ENSMUSP00000046999

    UniGene: Mm.4746

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