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  4. Recombinant Mouse Hamartin (Tsc1), partial

Recombinant Mouse Hamartin (Tsc1), partial

  • 中文名称：
    小鼠Tsc1重组蛋白
  • 货号：
    CSB-YP863631MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tsc1重组蛋白
  • 货号：
    CSB-EP863631MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tsc1重组蛋白
  • 货号：
    CSB-EP863631MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tsc1重组蛋白
  • 货号：
    CSB-BP863631MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tsc1重组蛋白
  • 货号：
    CSB-MP863631MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tsc1
  • Uniprot No.：
    Q9EP53
  • 别名：
    Tsc1; Kiaa0243; Hamartin; Tuberous sclerosis 1 protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1.
  • 基因功能参考文献：
    1. that Tsc1 specifically regulated the expression of groups of gene sets critically involved in dendritic cells survival, proliferation, metabolism and antigen presentation PMID: 29294307
    2. Moderate increase of TSC1 expression can enhance overall health, particularly cardiovascular health, and improve survival in a gender-specific manner. PMID: 28400571
    3. Tsc1 role in the differentiation of the neural stem cells. PMID: 29184052
    4. TSC1 role in the survival of myelinating oligodendrocytes. PMID: 27416896
    5. The results reveal a role for Tsc1-dependent inhibition of mTORC1 activation during immature NK cell development. PMID: 27601261
    6. Conditional knockout of Tsc1 led to enhanced proliferation and increased reactive oxygen species production and phagocytosis in alveolar macrophages. PMID: 29522719
    7. Co-electroporation of the different aberrant alleles and varying amounts of wildtype TSC1 surprisingly revealed already minimal amounts of functional hamartin to be sufficient for phenotype rescue PMID: 27425891
    8. We established chondrocyte-specific TSC-1 knockout (KO) mice to overactivate the energy metabolic component. PMID: 28523278
    9. the developmental timing of TSC1 loss dictates the severity of neuronal and glial abnormalities and resulting epilepsy PMID: 29023667
    10. This study therefore identifies Tsc1 as a novel candidate Anterior segment dysgenesis gene. PMID: 28250050
    11. Our study identifies Tsc1 as a crucial signaling checkpoint in Dendritic cells (DCs) essential for preserving T-cell homeostasis and response. PMID: 28079897
    12. loss of Pten, which in cones results in less robust mTORC1 activation when compared with loss of Tsc1, still affords long-term cone survival. PMID: 27362797
    13. Here, we provide evidence that deletion of Tsc1 from OPCs, but not differentiating oligodendrocytes, is beneficial to remyelination. This finding contrasts with the loss of oligodendroglia and hypomyelination seen with Tsc1 or Tsc2 deletion in the oligodendrocyte lineage during CNS development and points to important differences in the regulation of developmental myelination and remyelination. PMID: 28694334
    14. these findings highlight a critical role of TSC1 in regulating innate immunity by control of the mTOR1-C/EBPbeta pathway. PMID: 27593484
    15. Recombination and loss of Tsc1 was demonstrated in skin fibroblasts in vivo and in cultured skin fibroblasts. Loss of Tsc1 in fibroblasts in mice does not lead to a model of angiomyolipoma or lymphangioleiomyomatosis. PMID: 27907099
    16. Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Reducing filamin A (FLNA) levels has been shown to decrease Tsc1(+/-) dendritic complexity, these data suggest that increased FLNA levels in Tsc1(+/-) mice contribute to abnormal dendritic patterning in the Tsc1 heterozygote condition of individuals with tuberous sclerosis complex. PMID: 27345385
    17. The present study demonstrates for the first time evidence of microglial activation in a mouse model of TSC with mutation tsc1. PMID: 27263494
    18. suppression of AKT by hyperactivation of mTORC1, inhibition on nuclear ERalpha signaling, and down-regulation of cell-cycle-driving proteins play important roles in the retarded mammary development induced by Tsc1 deletion. PMID: 26795955
    19. TSC1 knockout mice are lean, glucose intolerant with a decreased activation of protein kinase B (Akt/PKB) targets that regulate glucose transporters in skeletal muscle. PMID: 27004103
    20. a pivotal role for Tsc1 in regulating various aspects of visual-pathway development, is reported. PMID: 26449264
    21. Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity. PMID: 26159807
    22. TSC1-KO results in the accumulation of transitional-1 B cells and progressive losses of B cells as they mature beyond the T1 stage. However, Peyer's patch germinal centers are unimpaired in TSC1-KO mice. PMID: 26000908
    23. TSC1 deletion led to enhanced mTORC1 signaling in neural crest derived bones and the increase in bone formation is responsible for the aberrantly increased bone mass. PMID: 25639352
    24. Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 with a Darpp32-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas. PMID: 25548102
    25. Striatum-specific deletion of TSC1 accelerated the onset of motor coordination abnormalities and caused premature death in an Huntington's Disease mouse model. PMID: 25351248
    26. Data indicate that all neurogenin 3 (Neurog3)-tuberous sclerosis complex 1 (Tsc1)-/- mice developed notable adenocarcinoma-like lesions in pancreas starting from the age of 100 days old. PMID: 25425965
    27. Improved insulin sensitivity upon short-term protein restriction requires TSC1 in mice. PMID: 25131199
    28. This study demonstrates that TSC1-mTORC1 signaling contributes to the brown-to-white adipocyte phenotypic switch. PMID: 25213336
    29. The mTORC1 hyperactivation by Tsc1 deletion accelerated malignant phenotypes, including increased tumour mass and enhanced microvascular formation, leading to intracranial haemorrhage. PMID: 24368778
    30. TSC1 acute down-regulation is detrimental to the survival of both primary and transformed T cells PMID: 24633152
    31. These findings provide direct evidence of a CD8 T cell-intrinsic role for TSC1 in the regulation of antigen-specific primary and memory responses. PMID: 24818661
    32. cardiomyopathy caused by cardiac Tsc1 deficiency PMID: 24576459
    33. Tsc1 loss induces mesothelioma. PMID: 23851502
    34. Tsc1(Delta/Delta) macrophages are refractory to interleukin (IL)-4-induced M2 polarization but produce increased inflammatory responses to proinflammatory stimuli. PMID: 24280772
    35. TSC1-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions, resulting in the predominance of iNKT-1 cells. PMID: 24614103
    36. Loss of TSC1 and activation of mTORC1 results in dedifferentiation and dysfunction of the collecting-duct and causes hyperkalemia. PMID: 24203997
    37. Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. PMID: 24282297
    38. T-cell-specific TSC1 deletion increased Th1 & Th17 differentiation & led to severe intestinal inflammation. Conditional deletion in Tregs impaired their suppressive activity. TSC1 is a checkpoint for maintaining immune homeostasis. PMID: 24270422
    39. Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice. PMID: 23475984
    40. Hap1 knockdown in hippocampal neurons induces the downregulation of Tsc1 and stimulates the activity of mTORC1. PMID: 24227713
    41. HIF1a acts as a molecular determinant of newborn neuron survival; its TSC1-dependent up-regulation gave Tsc1(null) neurons a survival advantage, despite their misplacement in a novel microenvironment. PMID: 23349360
    42. TSC1 deficiency in Dendritic cells results in increased mTORC1 but decreased mTORC2 signaling, altered cytokine production, impaired CIITA/MHC-II expression, and defective Ag presentation to CD4 T cells after TLR4 stimulation. PMID: 23776173
    43. This study demonstrate that abnormalities in a discrete population of neurons can cause global brain dysfunction and that phenotype severity depends on developmental timing and degree of mosaic Tsc1 deletion. PMID: 23664552
    44. Our data suggest that conditional knockout of Tsc1 in granulosa cells promotes reproductive activity in mice. PMID: 23335988
    45. TSC1 regulates cell polarity-associated formation of actin fibers through the spatial regulation of Rho family of small GTPases. PMID: 23355874
    46. TSC1 is crucial for T-cell anergy by inhibiting mTORC1 signaling through both ICOS-dependent and -independent mechanisms. PMID: 22891340
    47. These findings support an important role for the Tsc1 gene during GABAergic interneuron development, function, and possibly migration. PMID: 22021912
    48. Tsc1-mutant cells from the neonatal and juvenile subventricular zone generate brain lesions and structural abnormalities; these findings also raise the hypothesis that micronodules and the persistent infiltration of cells to forebrain structures may contribute to network malfunction leading to progressive neuropsychiatric symptoms in TSC PMID: 22068588
    49. In this study of tuberous sclerosis complex pathogenesis in the kidney, the mouse Tsc1 gene was inactivated in the distal convoluted tubules, and kidney development was monitored for pathology. PMID: 22674026
    50. findings demonstrate new roles for Tsc1 in Purkinje cell function and define a molecular basis for a cerebellar contribution to cognitive disorders such as autism; loss of Tsc1 in mouse cerebellar PCs results in autistic-like behaviours, including abnorma PMID: 22763451

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 数据库链接：

    KEGG: mmu:64930

    STRING: 10090.ENSMUSP00000028155

    UniGene: Mm.224354

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