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  4. Recombinant Mouse H-2 class I histocompatibility antigen, D-B alpha chain (H2-D1), partial

Recombinant Mouse H-2 class I histocompatibility antigen, D-B alpha chain (H2-D1), partial

  • 中文名称：
    小鼠H2-D1重组蛋白
  • 货号：
    CSB-YP355779MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠H2-D1重组蛋白
  • 货号：
    CSB-EP355779MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠H2-D1重组蛋白
  • 货号：
    CSB-EP355779MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠H2-D1重组蛋白
  • 货号：
    CSB-BP355779MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠H2-D1重组蛋白
  • 货号：
    CSB-MP355779MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    H2-D1
  • Uniprot No.：
    P01899
  • 别名：
    H2-D1; H-2 class I histocompatibility antigen; D-B alpha chain; H-2D(B)
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the presentation of foreign antigens to the immune system.
  • 基因功能参考文献：
    1. many self-peptides in the L(d) system (or the HLA-B system) would exhibit enhanced binding to Arg(97) alleles compared with Trp(97) alleles. PMID: 24064213
    2. The identification and characterization of two CD4+ T cell epitopes of Lpp20 helps understand the protective immunity of Lpp20 in H.pylori infection. PMID: 23234363
    3. Data show that At early stages, tumors demonstrated reduced MHC class I expression and increased expression of natural killer group 2D ligands (NKG2D-L). PMID: 19950185
    4. Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin PMID: 11842259
    5. A deecline in H-2D(B) and H-2D(K) expression with increasing thickness of cutaneous melanomas in transgenic mice and its reversal by interferon gamma therapy results implicate a regulatory defect as a principal cause of the loss of MHC class I antigens. PMID: 12140378
    6. Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics. PMID: 12682111
    7. efficient control of solid allogeneic tumors by NK cells depends on codelivery of both B7-1 and major histocompatibility complex class I (H-2Dd)on the tumor cells. PMID: 12933569
    8. crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin PMID: 16511243
    9. Data show that, despite the absence of H2-D1 and H2-K1 moecules, adult Purkinje cell in these transgenic mice are monoinnervated as in wild-type animals. PMID: 18418877
    10. class I single-chain trimers are more immunogenic than even preprocessed Ag in the form of an epitope minigene PMID: 19342630
    11. results show that neuronal MHC class Ia (H2-K(b)/D(b)) molecules are present in motor axons, are important for organization of neuromuscular junctions and motor recovery after nerve lesion, and that Schwann cells may mediate their actions PMID: 19864563
    12. crystal structure PMID: 11580250

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    MHC class I family
  • 数据库链接：

    KEGG: mmu:14964

    STRING: 10090.ENSMUSP00000134570

    UniGene: Mm.439675

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