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  4. Recombinant Mouse Guanine nucleotide-binding protein-like 3-like protein (Gnl3l)

Recombinant Mouse Guanine nucleotide-binding protein-like 3-like protein (Gnl3l)

  • 中文名称：
    小鼠Gnl3l重组蛋白
  • 货号：
    CSB-YP761348MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gnl3l重组蛋白
  • 货号：
    CSB-EP761348MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gnl3l重组蛋白
  • 货号：
    CSB-EP761348MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gnl3l重组蛋白
  • 货号：
    CSB-BP761348MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gnl3l重组蛋白
  • 货号：
    CSB-MP761348MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gnl3l
  • Uniprot No.：
    Q6PGG6
  • 别名：
    Gnl3lGuanine nucleotide-binding protein-like 3-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-577
  • 氨基酸序列
    MMKIRHKNKK PGKGSKGCKK PARQNGKKVT SRPSSAPQIV HGNDHASREA ELKKKRVEEM REKQQVAREQ ERQRHRTMES YCQDVLKRQQ EFEQKEEVLQ ELNMFPQLDD EATRKAYYKE FRKVVEYSDV ILEVLDARDP LGCRCFQMEE TVLRAEGNKK LVLVLNKIDL VPKEIVEKWL EYLLNELPTV AFKASTQHHQ VKNLTRCKVP VDQASESLLK SRACFGAENL MRVLGNYCRL GEVRGHIRVG VVGLPNVGKS SLINSLKRSR ACSVGAVPGV TKFMQEVYLD KFIRLLDAPG IVPGPNSEVG TILRNCIHVQ KLADPVTPVE TILQRCNLEE ISSYYGVSGF QTTEHFLTAV AHRLGKKKKG GVYSQEQAAK AVLADWVSGK ISFYTLPPPT HTLPTHLSAE IVKEMTEVFD IEDTEHANED TMECLAVGES DELLGDMDPQ EMEVRWLHSP LVKIADAIEN RSTVYKIGNL TGYCTKPNRN QMGWPKRNVD HHCPQNNRVV EVSSVDRRPM LQRILETDPL QQGQALASAL KNKKKLQKRS DKIATKLSDS MMSMLDLSGN SDDCAGD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
  • 基因功能参考文献：
    1. work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor)by GNL3L through coactivator competition. PMID: 17623774
    2. GNL3L mediates the mitotic increase of TRF1 protein and promotes the metaphase-to-anaphase transition. PMID: 19487455
  • 亚细胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    TRAFAC class YlqF/YawG GTPase family
  • 数据库链接：

    KEGG: mmu:237107

    STRING: 10090.ENSMUSP00000026297

    UniGene: Mm.45987

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