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  4. Recombinant Mouse G-protein coupled receptor family C group 6 member A (Gprc6a), partial

Recombinant Mouse G-protein coupled receptor family C group 6 member A (Gprc6a), partial

  • 中文名称：
    小鼠Gprc6a重组蛋白
  • 货号：
    CSB-YP817012MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gprc6a重组蛋白
  • 货号：
    CSB-EP817012MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gprc6a重组蛋白
  • 货号：
    CSB-EP817012MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gprc6a重组蛋白
  • 货号：
    CSB-BP817012MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gprc6a重组蛋白
  • 货号：
    CSB-MP817012MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gprc6a
  • Uniprot No.：
    Q8K4Z6
  • 别名：
    Gprc6aG-protein coupled receptor family C group 6 member A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
  • 基因功能参考文献：
    1. If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A. PMID: 28180060
    2. findings imply the possibility to ameliorate menopause-induced metabolic disorder by GPRC6A and adiponectin signaling PMID: 29194451
    3. GPCR6A activation by Alum leads to the initiation of innate inflammatory responses whereas it is an important signal for the limitation of adaptive immune responses induced by Alum, partially explained by B cell IL-10. PMID: 26602597
    4. the loss of osteocalcin/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis PMID: 24009262
    5. the GPRC6A receptor is involved in regulating exercise behaviour PMID: 23680430
    6. Activation of GPRC6A by L-arginine did not stimulate insulin secretion. PMID: 22714012
    7. Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. PMID: 23271661
    8. the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 secretion PMID: 23269670
    9. GPRC6A is a novel molecular target for regulating prostate growth and cancer progression. PMID: 21681779
    10. These findings suggest that GPRC6A is a candidate for mediating the response to Ocn in the bone-pancreas endocrine loop regulating insulin signaling. PMID: 21425331
    11. GPRC6A is functionally important in regulating non-genomic effects of androgens in multiple tissues. PMID: 20947496
    12. Osteoblasts and BMSCs derived from GPRC6A(-/-) mice exhibited an attenuated response to extracellular calcium-stimulated extracellular signal-related kinase (ERK) activation, diminished alkaline phosphatase expression, and impaired mineralization ex vivo PMID: 19874200
    13. Cloning and characterization of mouse GPRC6A family C orphan receptor show the highest degree of amino acid identity to the fish 5.24 odorant receptor and mammalian calcium-sensing receptor (CaSR). PMID: 15816861
    14. GPRC6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor PMID: 16199532
    15. GPRC6A(-/-) mice have a metabolic syndrome characterized by defective osteoblast-mediated bone mineralization, abnormal renal handling of calcium and phosphorus, fatty liver, glucose intolerance and disordered steroidogenesis. PMID: 19050760
    16. data do not support a role for GPRC6A in normal bone physiology PMID: 19103720
    17. GPRC6A is a promiscuous L-alpha-amino acid receptor most potently activated by basic amino acids. PMID: 15576628

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 组织特异性：
    Expressed at high level in liver, lung, spleen and heart. Expressed at lower level in kidney, skeletal muscle and brain. Expressed in E7, E11, E15 and E17 embryos.
  • 数据库链接：

    KEGG: mmu:210198

    STRING: 10090.ENSMUSP00000020062

    UniGene: Mm.221031

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