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  4. Recombinant Mouse Fibrillin-2 (Fbn2), partial

Recombinant Mouse Fibrillin-2 (Fbn2), partial

  • 中文名称：
    小鼠Fbn2重组蛋白
  • 货号：
    CSB-YP733789MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fbn2重组蛋白
  • 货号：
    CSB-EP733789MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fbn2重组蛋白
  • 货号：
    CSB-EP733789MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fbn2重组蛋白
  • 货号：
    CSB-BP733789MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fbn2重组蛋白
  • 货号：
    CSB-MP733789MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fbn2
  • Uniprot No.：
    Q61555
  • 别名：
    Fbn2; Fbn-2Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.; Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels.
  • 基因功能参考文献：
    1. Studies provide evidence for the unique role of fibrillin-2 in regulating BMP-dependent limb patterning and its distinct impact from fbn1 proteins on the commitment and differentiation of marrow mesenchymal stem cells. [review] PMID: 26408953
    2. Fibrillin-2 and periostin are target genes in Osterix-mediated osteoblast differentiation. PMID: 27751812
    3. Fibrillin-2 plays a role in forelimb muscle differentiation and infiltration of fat into the limb connective tissue space. PMID: 26114882
    4. the bronchial epithelial dysplasia accompanying microfibril dysregulation in Adamtsl2(-/-) mice cannot be reversed by TGFbeta neutralization, and thus might be mediated by other mechanisms. PMID: 25762570
    5. We propose that the Mp "worse-than-null" eye phenotype plausibly results from a failure in normal trafficking of proteins that are co-expressed with Fbn2 within the ciliary margin PMID: 24348270
    6. Fbn2 has an indispensable role in ocular morphogenesis in mice. The high incidence of iris coloboma in Fbn2-null animals implies a previously unsuspected role in optic fissure closure. PMID: 24130178
    7. fibrillin-2 exerts a greater positive influence on the mechanical properties of bone than fibrillin-1 assemblies PMID: 21440062
    8. Findings indicate that Fbn2 is involved in integrity of structures required for strength in limb movement. PMID: 20161761
    9. there are distinct functions for fibrillin-2 in peripheral nerves PMID: 12429739
    10. Relaxin regulates its mRNA and protein expression by human dermal fibroblasts and murine fetal skin PMID: 12590922
    11. demonstrate a role for fibrillin-2 in bone and soft connective tissue morphological and biochemical processes PMID: 18838118
    12. coordinated expression of the E2F family is critical for the transcriptional regulation of fibrillin-2 during chondrogenesis. PMID: 19142862

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  • 亚细胞定位：
    Secreted.; [Fibrillin-2]: Secreted, extracellular space, extracellular matrix.; [Placensin]: Secreted.
  • 蛋白家族：
    Fibrillin family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:14119

    STRING: 10090.ENSMUSP00000025497

    UniGene: Mm.20271

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