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  4. Recombinant Mouse Fez family zinc finger protein 2 (Fezf2)

Recombinant Mouse Fez family zinc finger protein 2 (Fezf2)

  • 中文名称：
    小鼠Fezf2重组蛋白
  • 货号：
    CSB-YP866847MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fezf2重组蛋白
  • 货号：
    CSB-EP866847MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fezf2重组蛋白
  • 货号：
    CSB-EP866847MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fezf2重组蛋白
  • 货号：
    CSB-BP866847MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fezf2重组蛋白
  • 货号：
    CSB-MP866847MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fezf2
  • Uniprot No.：
    Q9ESP5
  • 别名：
    Fezf2; Fez; Fezl; Zfp312Fez family zinc finger protein 2; Forebrain embryonic zinc finger-like protein 2; Zinc finger protein 312; Zinc finger protein Fez-like
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-455
  • 氨基酸序列
    MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP AALEADSSQS KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSEFWKSSLR AGGGGGGGSG GGAPVCGASG LCKTNCGVCC KAELGLAPSA LPAGRVIKPQ VINQAVGLPA SGSLYYFNYL DSTAYPPSEL LGGHLFPSGL LNAQAPTSLA AHPKLFLLEN AKLASLAADK FPHPASYPHK ERLHAPLEQV LKENSALTAE RGGVKSHSKL PGGSTDSKPK NFTCEVCGKV FNAHYNLTRH MPVHTGARPF VCKVCGKGFR QASTLCRHKI IHTQEKPHKC NQCGKAFNRS STLNTHIRIH AGYKPFVCEF CGKGFHQKGN YKNHKLTHSG EKQYKCTICN KAFHQVYNLT FHMHTHNDKK PFTCATCGKG FCRNFDLKKH VRKLHDSVGP TATPSAKDLA RTVQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation.
  • 基因功能参考文献：
    1. Taken together, our results show that Fezf2 is indispensable in differentiation of bipolar precursors into cone OFF bipolar cells and in functional maturation of cone ON bipolar cells during development of mouse retina. PMID: 29559301
    2. findings indicate a wider role for Fezf2 within gene expression networks that underpin the diversity of layer 5 cortical projection neurons. PMID: 26234885
    3. transient expression ofFezf2in the retina modulates the transcription ofBrn3band the survival of RGCs. PMID: 26861874
    4. Study shows that the transcription factor Fezf2 directly regulates various tissue-restricted antigens genes in medullary thymic epithelial cells independently of Aire. Mice lacking Fezf2 in mTECs displayed severe autoimmune symptoms, including the production of autoantibodies and inflammatory cell infiltration targeted to peripheral organs. PMID: 26544942
    5. Satb2 and Fezf2 regulation promotes subcerebral projection neuron identity in the developing cerebral cortex PMID: 26324926
    6. Characterized the activity of regulatory regions around the Fezf2 locus at stages of corticogenesis. Identified a promoter that was sufficient for expression in the cerebral cortex, and enhancers that drove reporter gene expression in forebrain domains. PMID: 24618363
    7. Fezf2 is a selector gene able to regulate the expression of gene sets that collectively define mouse corticospinal motor neurons (CSMN). PMID: 24997765
    8. Ectopic Fezf2 expression is sufficient to redirect the fate of subventricular zone stem cells. PMID: 25002477
    9. Our findings establish a new, distinct physiological identity of Fezf2-expressing neurons within mature motor cortex. PMID: 24647950
    10. These results identify Fezf2 radial glial cells as a multipotent neocortical progenitor and suggest that the existence, and molecular identity, of laminar-fate-restricted RGCs awaits further investigation. PMID: 24314728
    11. findings reveal that SOX transcription factors converge onto a cis-acting element of Fezf2 and form critical components of a regulatory network controlling the identity and connectivity of corticospinal neurons PMID: 22678282
    12. Fezf2 controls the specification of telencephalic progenitors from mouse embryonic stem cell PMID: 21330470
    13. These results identify Fezf1 and Fezf2 as important regulators of olfactory system development and sensory neuron identity. PMID: 21452247
    14. This study demonstrated that fez2 in the neocortex individual populations of projection neurons cell-extrinsically control the laminar fate of interneurons and the assembly of local inhibitory circuitry. PMID: 21338885
    15. the study demonstrated that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling. PMID: 20953195
    16. Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain. PMID: 20431123
    17. Fezl functions in the formation of subplate neurons and thalamocortical axons. PMID: 15188439
    18. Fezl is required for the birth and specification of corticospinal motor neurons. PMID: 16157277
    19. Putative zinc-finger transcriptional repressor Fezl regulates the specification or differentiation of layer 5 and 6 neurons during mammalian cortical development. PMID: 16284245
    20. Zfp312 plays a critical role in layer- and neuronal subtype-specific patterning of cortical axonal projections PMID: 16314561
    21. These data indicate that Fez and Fezl repress the caudal diencephalon fate in the rostral diencephalon, and ZLI formation probably depends on Fez/Fezl-mediated formation of diencephalon subdivisions. PMID: 16971467
    22. In Fezl-deficient mice, most of the thalamic and cortical axons stop in the internal capsule and at the pallial-subpallial boundary at E14.5. This abnormality is transient, and the thalamic and cortical axons reach their targets at E15.5. PMID: 17503485
    23. The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. PMID: 18678899

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Highly expressed in neocortical layer V, moderately expressed in layer VI. Expressed in subcortically projecting neurons.
  • 数据库链接：

    KEGG: mmu:54713

    STRING: 10090.ENSMUSP00000022262

    UniGene: Mm.34644

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