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  4. Recombinant Mouse Ferritin, mitochondrial (Ftmt)

Recombinant Mouse Ferritin, mitochondrial (Ftmt)

  • 中文名称：
    小鼠Ftmt重组蛋白
  • 货号：
    CSB-YP866687MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ftmt重组蛋白
  • 货号：
    CSB-EP866687MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ftmt重组蛋白
  • 货号：
    CSB-EP866687MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ftmt重组蛋白
  • 货号：
    CSB-BP866687MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ftmt重组蛋白
  • 货号：
    CSB-MP866687MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ftmt
  • Uniprot No.：
    Q9D5H4
  • 别名：
    Ftmt; Ferritin; mitochondrial; EC 1.16.3.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    50-237
  • 氨基酸序列
    A SVASSQDSTR PSRVRQNFHP DSEAAINRQI NLELYASYVY LSMAYYFSRD DVALYNFSKY FLRQSLEERE HAEKLMKLQN QRGGRICLQD IKKPDKDDWE CGLRAMECAL LLEKNVNQSL LDLHTLASEK GDPHLCDFLE THYLHEQVKS IKELGDHVHN LVTMGAPAAG LAEYLFDKHT LGSESKH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
  • 基因功能参考文献：
    1. Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model. PMID: 28963372
    2. Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin. PMID: 27599360
    3. overexpression of MtFt causes a dramatic change in intracellular iron homeostasis and shunting iron to MtFt likely limits its availability for active iron proteins PMID: 15522954
    4. ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance PMID: 16448386
    5. mitochondrial ferritin has a role in tumor growth inhibition by cytosolic iron deprivation PMID: 16757684
    6. PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene PMID: 17565989
    7. Its association with cell types characterized by high metabolic activity and oxygen consumption suggests a role in protecting mitochondria from iron-dependent oxidative damage. PMID: 17625226
    8. ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritin H mRNA. PMID: 18076382
    9. ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation PMID: 18325346
    10. Our results provide evidence that the iron storage function of ferritin plays a major role in preventing iron-mediated cell and tissue damage. PMID: 19492434

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Ferritin family
  • 数据库链接：

    KEGG: mmu:67634

    STRING: 10090.ENSMUSP00000025388

    UniGene: Mm.179144

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