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  4. Recombinant Mouse FH1/FH2 domain-containing protein 3 (Fhod3), partial

Recombinant Mouse FH1/FH2 domain-containing protein 3 (Fhod3), partial

  • 中文名称：
    小鼠Fhod3重组蛋白
  • 货号：
    CSB-YP758839MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fhod3重组蛋白
  • 货号：
    CSB-EP758839MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fhod3重组蛋白
  • 货号：
    CSB-EP758839MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fhod3重组蛋白
  • 货号：
    CSB-BP758839MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fhod3重组蛋白
  • 货号：
    CSB-MP758839MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fhod3
  • Uniprot No.：
    Q76LL6
  • 别名：
    Fhod3; Fhos2; Kiaa1695FH1/FH2 domain-containing protein 3; Formin homolog overexpressed in spleen 2; mFHOS2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in actin filament polymerization in cardiomyocytes. Actin-organizing protein that may cause stress fiber formation together with cell elongation.
  • 基因功能参考文献：
    1. Perinatal KO of Fhod3 in the heart caused juvenile lethality at around day 10 after birth with enlarged hearts composed of severely impaired myofibrils, indicating that Fhod3 is crucial for postnatal heart development. PMID: 29158260
    2. these findings suggest the possibility that Fhod3 contributes to the pathogenesis of cMyBP-C-related cardiomyopathy and that Fhod3 is critically involved in cMyBP-C-mediated regulation of cardiac function via direct interaction. PMID: 29686099
    3. Up regulation of FHOD3 play a crucial role in the pathogenesis of cardiac hypertrophy in mouse model. PMID: 28438902
    4. during embryonic cardiogenesis, Fhod3 functions as the essential reorganizer of actin filaments at the central region of maturating sarcomeres via the actin-binding activity of the FH2 domain PMID: 26848968
    5. Analysis of casein kinase 2 alpha knockout mice showed that phosphorylation by casein kinase 2 is also required for proper targeting of muscle Fhod3 to the myofibrils in embryonic cardiomyocytes in situ. PMID: 23052206
    6. embryonic heart of mice specifically expresses the Fhod3 mRNA isoform harboring the three alternative exons PMID: 22509354
    7. actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells. PMID: 19706596

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Formin homology family
  • 组织特异性：
    Expressed in the heart, including left ventricle, kidney, brain and skeletal muscle, including soleus and tibialis anterior (at protein level).
  • 数据库链接：

    KEGG: mmu:225288

    STRING: 10090.ENSMUSP00000041361

    UniGene: Mm.329322

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