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  4. Recombinant Mouse F-box-like/WD repeat-containing protein TBL1X (Tbl1x)

Recombinant Mouse F-box-like/WD repeat-containing protein TBL1X (Tbl1x)

  • 中文名称：
    小鼠Tbl1x重组蛋白
  • 货号：
    CSB-YP879438MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tbl1x重组蛋白
  • 货号：
    CSB-EP879438MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tbl1x重组蛋白
  • 货号：
    CSB-EP879438MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tbl1x重组蛋白
  • 货号：
    CSB-BP879438MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tbl1x重组蛋白
  • 货号：
    CSB-MP879438MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbl1x
  • Uniprot No.：
    Q9QXE7
  • 别名：
    Tbl1x; Tbl1; F-box-like/WD repeat-containing protein TBL1X; Transducin beta-like protein 1X
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-527
  • 氨基酸序列
    MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQANA AAAAAAAAAT ATSTAATTPA AAAQQNPPKN GEATVNGEEN GAHAINNHSK PMEIDGDVEI PPSKATVLRG HESEVFICAW NPVSDLLASG SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD VTSLDWNSDG TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNKK GNYILSAGVD KTTIIWDAHT GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG CDRPVKTFQG HTNEVNAIKW DPSGMLLASC SDDMTLKIWS MKQDACVHDL QAHSKEIYTI KWSPTGPATS NPNSNIMLAS ASFDSTVRLW DVERGVCIHT LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH IWNTQSGSLV HSYRGTGGIF EVCWNARGDK VGASASDGSV CVLDLRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
  • 基因功能参考文献：
    1. These results suggest that TBL1X is needed for the full activation of TRH and TSHbeta gene promoters by unliganded thyroid hormone receptors. PMID: 29794369
    2. TBL1 deficiency resulted in inhibition of fatty acid oxidation due to impaired functional cooperation with its heterodimerization partner TBL-related (TBLR) 1 and the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha PMID: 21459324
    3. TBLR1 and TBL1 have roles in specific nuclear receptor-mediated gene activation events PMID: 14980219
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat EBI family
  • 组织特异性：
    Expressed in the cochlea.
  • 数据库链接：

    KEGG: mmu:21372

    STRING: 10090.ENSMUSP00000085549

    UniGene: Mm.258476

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