Recombinant Mouse Extracellular calcium-sensing receptor (Casr), partial

1. CaSR signaling reduces AQP2 abundance both via AQP2-targeting miRNA-137 and the p38-MAPK/AQP2-pS261/ubiquitination/proteasomal axis. PMID: 29212817
2. The identification of the activation of CaSR-mediated protective pathway in renal cells sheds light on a possible cellular protective mechanism against Cd-induced kidney injury. PMID: 29348484
3. In mouse strains with parathyroid-specific deletions of Klotho and CaSR and dual deletion of both genes, ablating CaSR in the parathyroid glandss increases PTH synthesis. CaSR together with Klotho regulates PTH biosynthesis and parathyroid growth. PMID: 29618612
4. These findings indicate that cardiac function could be enhanced significantly by combination therapy with CaSR inhibition and ESC transplantation; the effect was better than ESC transplantation alone, and the mechanism might be associated with a reduction in cell apoptosis via the inhibition of the MAPK pathway. PMID: 28281186
5. These studies indicate that the CaSR activation impairs glucose tolerance by a combination of alpha- and beta-cell defects and also influences pancreatic islet mass. PMID: 28575322
6. These findings suggest that trabecular bone formation can occur independently of the CaSR, and that the CaSR plays a collaborative role in the PTH anabolic effects on bone. PMID: 26579618
7. Vdr and Casr are required for beta-catenin-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding. PMID: 28368538
8. we suggest that decreased Ca2+ levels and increased CaSR expression might be involved in increased insulin secretion to compensate for insulin resistance in aged mice. PMID: 27441644
9. physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR. PMID: 26911344
10. CaSR was localized in the basolateral membrane of basolateral membrane of type-B intercalated cell and was more expressed during alkali-loading PMID: 25500736
11. Demonstrate a role for CaSR in cardiovascular system and suggest physiologically relevant changes in extracellular Ca(2+) concentrations could contribute to setting blood vessel tone levels and heart rate by directly acting on the cardiovascular CaSR. PMID: 26538090
12. Both vitamin D and calcium are needed for protection against malignant transformation of the colon and that their effect is modulated by the presence of a functional CaSR. PMID: 25758239
13. fluoride might be able to affect calcium homeostasis by regulating PTH, PTHrP, and CaSR PMID: 25645361
14. the activation of CaSR in the collecting duct prevents the cyclic AMP-dependent increase in AQP2-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin response. PMID: 25977473
15. Deoxynivalenol induced cholecystokinin and glucagon-like peptide 1 release by enteroendocrine cells in mediated by casR/TRPA1 signaling. PMID: 25787141
16. Calcium-sensing receptor has a role in airway hyperresponsiveness and inflammation in allergic asthma PMID: 25904744
17. CaSR and OGR1 reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification impairs CaSR PMID: 26261299
18. results demonstrate a critical tumor suppressive role of CaSR in the colon. Restoration of CaSR expression and function is linked to regulation of the balance between proliferation, differentiation, and apoptosis PMID: 25701758
19. Data show that gamma-Glutamyl cysteine and gamma-glutamyl valine -mediated activation of calcium-sensing receptor (CaSR) prevents tumor necrosis factor-alpha (TNF-alpha)-induced pro-inflammatory signaling. PMID: 25558818
20. nearly doubled in GPR4-/- kidneys, in the absence of apparent disturbances of Ca(2+) homeostasis PMID: 25972512
21. These results suggest a new paradigm for regulation of intestinal ion transport in which HCO3(-) secretion may be fine-tuned by CaSR in accordance with nutrient availability and state of digestion and absorption. PMID: 25792563
22. The genetic mutations in the calcium-sensing receptor from patients with autosomal dominant hypocalcemia repressed the transcription of miR-9 and miR-374 genes. PMID: 25071082
23. CaSR activation triggers Ca(2+)-dependent duodenal bicarbonate secretion PMID: 25331955
24. the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice PMID: 24842610
25. brain phenotype in postnatal CaSR null mice, was investigated. PMID: 23564401
26. Increased luminal calcium concentration leads to enhanced fluid reabsorption in the proximal tubule, a process related to activation of CaSR. PMID: 23615500
27. These data together support the concept that CaSR overexpression and overactivity play a causal role in potentiating traumatic brain injury PMID: 23360235
28. Ca2+ -sensing receptor and parathyroid hormone are functionally coupled to maintain erythrocyte homeostasis PMID: 23528155
29. CaSR is functionally expressed in mESCs, and activation of CaSR is involved in the differentiation of mESCs into cardiomyocytes by facilitating the expression of NKx2.5 and GATA-4. PMID: 23314289
30. Data from transgenic/knockout mice suggest that mammary gland CaSR is important in PTHrP (parathyroid hormone-like peptide) secretion in milk, in calcium secretion (in milk) and excretion (in urine), and in avoiding hypercalcemia in lactating mothers. PMID: 23782944
31. Data suggest that CaSR signaling in mesenteric arteries stimulates eNOS (nitric oxide synthase 3) and nitric oxide production and regulates calcium-induced vasodilation. Data from knockout mice suggest that eNOS knockout upregulates CaSR expression. PMID: 23639802
32. Induced formation of aberrant crypt foci (ACF) caused by azoxymethane (AOM) injection in 'rescued' CaSR-/PTH- (C-/P-) double knockout colons compared with colons from control CaSR+/PTH+ (C+/P+) mice to study the role of CaSR. PMID: 23545937
33. Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. PMID: 23271661
34. Loss of the full-length CaSR impairs the ability of PTH and CaSR knockout mice to mitigate the rise in serum Mg induced by Mg loading when the mice have been rendered normocalcemic by supplementation with Ca but not in nonsupplemented hypocalcemic mice. PMID: 23360827
35. Activation of the Ca(2+)-sensing receptor in the thick ascending limb increases Cldn14 expression, which in turn blocks the paracellular reabsorption of Ca(2+). PMID: 23283989
36. the murine calcium-sensing receptor (CASR) activates the NLRP3 inflammasome, mediated by increased intracellular Ca(2 ) and decreased cellular cyclic AMP (cAMP); findings indicate that Ca(2) and cAMP are two key molecular regulators of the NLRP3 inflammasome that have critical roles in the molecular pathogenesis of cryopyrin-associated periodic syndromes PMID: 23143333
37. The calcium-sensing receptor (CaR) plays a role in normal epidermal development. PMID: 22622426
38. renal Casr regulates calcium reabsorption in the thick ascending limb, independent of any change in PTH, by increasing the lumen-positive driving force for paracellular Ca(2+) transport PMID: 22997254
39. The extracellular calcium-induced increase in cytosolic Ca(2+) due to upregulated CaSR, contributes to the augmented Ca(2+) influx and excessive pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. PMID: 22730443
40. CaR-AQP2 interplay represents an internal renal defense to mitigate the effects of hypercalciuria on the risk of calcium precipitation during antidiuresis PMID: 22403735
41. The Ca(++) sensing receptor (CaSR) acts upstream of the microRNA-claudin-14 axis. PMID: 22373575
42. Cadherin Cdh2 (Ncad) and the calcium receptor Casr show higher gene expression and variability only in fetal bone marrowat 17.5 days post coitum (dpc). PMID: 22276210
43. CaR signaling in a broad population of osteoblasts is essential for bone development and remodeling. PMID: 21956637
44. CaSR control colonic epithelial cell proliferation in vivo and suggest that the mechanism involves regulation of beta-catenin phosphorylation. PMID: 22094462
45. Deletion of PTH in CaR- deficient mice resulted in rescue of early lethality, normocalcemia, increased serum phosphorus, and normalization in skeletal growth. PMID: 21966280
46. These results indicate that in neonates, the CaR mediates alterations in bone turnover in response to changes in dietary calcium and modulates PTH-stimulated bone turnover. PMID: 21542007
47. These findings indicate that amino acids have a direct effect on CCK cells to stimulate CCK release by activating CaSR and suggest that CaSR is the physiological mechanism through which amino acids regulate CCK secretion. PMID: 21183662
48. The present data suggest that CaSR is required for hormone secretion in the specific response to L-Phe by the native I cell, and that a receptor-mediated mechanism may inhibit hormone secretion in the absence of a fully functional CaSR. PMID: 21252045
49. that extracellular Ca(2+) does not trigger spontaneous glutamate release by simply increasing calcium influx but stimulates CaSR PMID: 21430159
50. PTH-mediated bone resorption may require calcium-stimulated CaSR-mediated enhancement of osteoclastic activity. PMID: 20200973

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KEGG: mmu:12374

STRING: 10090.ENSMUSP00000069080

UniGene: Mm.103619