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  4. Recombinant Mouse Epiplakin (Eppk1), partial

Recombinant Mouse Epiplakin (Eppk1), partial

  • 中文名称：
    小鼠Eppk1重组蛋白
  • 货号：
    CSB-YP851246MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Eppk1重组蛋白
  • 货号：
    CSB-EP851246MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Eppk1重组蛋白
  • 货号：
    CSB-EP851246MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Eppk1重组蛋白
  • 货号：
    CSB-BP851246MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Eppk1重组蛋白
  • 货号：
    CSB-MP851246MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Eppk1
  • Uniprot No.：
    Q8R0W0
  • 别名：
    Eppk1; EPPKEpiplakin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.
  • 基因功能参考文献：
    1. Epiplakin is a protective protein during acute pancreatitis, and that its loss causes impaired disease-associated keratin reorganization. PMID: 25232867
    2. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels. PMID: 25617501
    3. Lacking epiplakin affects cell differentiation of the corneal epithelium, as well as its proliferation activity and its structural integrity. PMID: 23599337
    4. Eppk1 serves as a useful marker for detecting the hepatic progenitor population in the developing and adult liver PMID: 21216305
    5. These results suggest that Eppk1 is expressed both in embryonic and adult retina and may be involved in retinal development. PMID: 20151282
    6. characterization of the epiplakin gene locus and the isolation of full-length epiplakin cDNA using BAC vectors; expression is restricted to epithelial tissues and its gene maps to mouse chromosome 15 PMID: 12791695
    7. EPPK might be linked functionally with keratin 6. PMID: 16382146
    8. Serves as a useful marker for detecting pancreatic progenitor cells in developing and regenerating pancreas. PMID: 18498355

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Apicolateral cell membrane. Basolateral cell membrane. Cell junction. Cell junction, hemidesmosome. Cell junction, tight junction. Cell projection.
  • 蛋白家族：
    Plakin or cytolinker family
  • 组织特异性：
    High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively
  • 数据库链接：

    KEGG: mmu:223650

    UniGene: Mm.259929

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