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  4. Recombinant Mouse Endothelial cell-selective adhesion molecule (Esam), partial

Recombinant Mouse Endothelial cell-selective adhesion molecule (Esam), partial

  • 中文名称：
    小鼠Esam重组蛋白
  • 货号：
    CSB-YP838786MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Esam重组蛋白
  • 货号：
    CSB-EP838786MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Esam重组蛋白
  • 货号：
    CSB-EP838786MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Esam重组蛋白
  • 货号：
    CSB-BP838786MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Esam重组蛋白
  • 货号：
    CSB-MP838786MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Esam
  • Uniprot No.：
    Q925F2
  • 别名：
    Esam; Esam1Endothelial cell-selective adhesion molecule
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Can mediate aggregation most likely through a homophilic molecular interaction.
  • 基因功能参考文献：
    1. ESAM expression in hematopoietic progenitors is essential for erythroid recovery after a bone marrow injury. PMID: 27111450
    2. Runx3 is required for cell identity, homeostasis and function of splenic Esam(high) dendritic cells. PMID: 24204843
    3. ESAM levels clearly mirror the shift of hematopoietic stem cells (HSC) between quiescence and activation, and the intensity of expression is prominent in comparison with other HSC-related antigens. PMID: 22649198
    4. ESAM regulates tumor metastasis through endothelial cell migration and tube formation in metastatic nodules. PMID: 20153339
    5. ESAM inactivation can reduce susceptibility to atherosclerosis by inhibiting plaque neovascularization and macrophage infiltration into the atheroma. PMID: 20406651
    6. findings support a model in which ESAM localizes to platelet contacts following platelet activation in order to limit thrombus growth and stability PMID: 19740102
    7. selectively expressed on endothelial cells and platelets; might be involved in interendothelial cell adhesion PMID: 11847224
    8. ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth PMID: 12819200
    9. The direct interaction between ESAM and MAGI-1 was confirmed by pull-down experiments. The two proteins formed stable complexes in transfected CHO cells. PMID: 15383320
    10. At endothelial tight junctions ESAM participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. PMID: 16818677
    11. ESAM marks hematopoietic stem cells in murine fetal liver and will facilitate studies of hematopoiesis throughout life. PMID: 19096010
    12. Thus, ESAM may regulate albumin extravasation at the glomeruli and play a role in the initiation of diabetic nephropathy. PMID: 19323980

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  • 亚细胞定位：
    Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed in the heart and lung. Weakly expressed in the kidney and skin. Expression is restricted to the vascular endothelial cells. Expressed in the kidney, heart and tongue (at protein level). Also expressed on megakaryocytes and activated plate
  • 数据库链接：

    KEGG: mmu:69524

    STRING: 10090.ENSMUSP00000002011

    UniGene: Mm.41751

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