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  4. Recombinant Mouse E3 ubiquitin-protein ligase UBR4 (Ubr4), partial

Recombinant Mouse E3 ubiquitin-protein ligase UBR4 (Ubr4), partial

  • 中文名称：
    小鼠Ubr4重组蛋白
  • 货号：
    CSB-YP025519MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ubr4重组蛋白
  • 货号：
    CSB-EP025519MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ubr4重组蛋白
  • 货号：
    CSB-EP025519MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ubr4重组蛋白
  • 货号：
    CSB-BP025519MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ubr4重组蛋白
  • 货号：
    CSB-MP025519MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ubr4
  • Uniprot No.：
    A2AN08
  • 别名：
    Ubr4; Kiaa0462; Zubr1E3 ubiquitin-protein ligase UBR4; EC 2.3.2.27; N-recognin-4; RING-type E3 ubiquitin transferase UBR4; Zinc finger UBR1-type protein 1; p600
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
  • 基因功能参考文献：
    1. Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from cultured podocytes and native glomeruli. Ubiquitylomic analysis of mouse glomeruli revealed that podocin is ubiquitylated at two lysine residues. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. PMID: 26792178
    2. This study is the first to identify a novel E3 ubiquitin ligase component, UBR4, in the murine SCN and to implicate the N-end rule degradation pathway as a potential player in regulating core clock mechanisms and photic entrainment. PMID: 25084275
    3. UBR4-deficient mice die during embryogenesis and exhibit pleiotropic abnormalities, including impaired vascular development in the yolk sac. PMID: 23431188
    4. Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding in mice. PMID: 16081543
    5. This study identified protein 600 (p600) as a novel microtubule-associated protein (MAP) developmentally regulated in neurons. p600 exhibits the unique feature to interact with the endoplasmic reticulum (ER). PMID: 18385319
    6. Found murine p600 (formally called RBAF600) copurified with the E7 oncoprotein in C127 cells. This interaction was found to correlate with the ability of E7 to increase transformation. PMID: 16081543
    7. Member of UBR box protein family, termed Ubr4. Binds to destabilizing N-terminal residues of N-end rule substrates. Participates in degradation of N-end rule substrates. PMID: 16055722

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
  • 蛋白家族：
    UBR4 family
  • 组织特异性：
    Widely expressed in adult and embryonic stages with highest levels in testis and brain.
  • 数据库链接：

    KEGG: mmu:69116

    STRING: 10090.ENSMUSP00000095433

    UniGene: Mm.271956

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