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  4. Recombinant Mouse E3 ubiquitin-protein ligase TRIM33 (Trim33), partial

Recombinant Mouse E3 ubiquitin-protein ligase TRIM33 (Trim33), partial

  • 中文名称：
    小鼠Trim33重组蛋白
  • 货号：
    CSB-YP859171MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim33重组蛋白
  • 货号：
    CSB-EP859171MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trim33重组蛋白
  • 货号：
    CSB-EP859171MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim33重组蛋白
  • 货号：
    CSB-BP859171MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim33重组蛋白
  • 货号：
    CSB-MP859171MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim33
  • Uniprot No.：
    Q99PP7
  • 别名：
    Trim33; Kiaa1113; E3 ubiquitin-protein ligase TRIM33; EC 2.3.2.27; Ectodermin homolog; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
  • 基因功能参考文献：
    1. Data show that tripartite motif 33 (TRIM33) mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes. PMID: 28844090
    2. Trim33 is thus revealed as being essential for the navigation of macrophages and neutrophils towards developmental or inflammatory cues within vertebrate tissues. PMID: 28724755
    3. Study reveals new important functions of TRIM33 in macrophage production and activation by LPS and pinpoints TRIM33 as an important transcriptional actor of monocyte/macrophage mediated inflammation. PMID: 27974684
    4. TRIM33 is necessary for osteoblast proliferation by regulating cell cycle and for differentiation via bone morphogenetic protein signaling pathway. PMID: 28063228
    5. these results indicate that Trim33 deficiency leads to the expansion of a subset of myeloid cells characterizing the myelodysplastic/myeloproliferative neoplasm. PMID: 27130375
    6. Trim33 altered expression of a small group of genes in the testis and the gene with the most significant increase was transcribed from an upstream RLTR10B. PMID: 26624618
    7. TRIM33 deficiency results in high expression of Ifnb1 at late stages of macrophages activation. PMID: 26592194
    8. our work indicates that TIF1gamma exerts its tumor-suppressive functions in part by promoting chromosomal stability. PMID: 26282171
    9. The findings reveal an essential role for TRIM33 in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation. PMID: 25919951
    10. This study demonistrated that Smad4 and Trim33 regulate neural stem cells in the developing cortex in mice. PMID: 23765158
    11. Epithelium-specific Tak1:Smad4- and Trim33:Smad4-double mutants display reduced expression of Mmp13 in palatal medial edge epithelial cells. PMID: 25523394
    12. The dermatomyositis autoantigen TIF1gamma is markedly up-regulated during muscle regeneration in human and mouse muscle cells. PMID: 25186009
    13. reduces invasion and metastasis of hepatocellular carcinoma cells PMID: 24954480
    14. These data provide a new paradigm for Tif1gamma in regulating the balance between lymphoid- and myeloid-derived hematopoietic stem cells (HSC) through TGF-beta signaling, leading to HSC aging. PMID: 25002492
    15. TIF1gamma plays essential roles in multiple murine blood lineages and that its function in transcription elongation is evolutionally conserved. PMID: 23159334
    16. Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. PMID: 22469842
    17. Study reports an essential role for TRIM33 in the activation of Gsc and Mixl1 by nodal signals, and delineate how Smads gain access to poised promoters of master regulators under the command of nodal TGF-beta signals. PMID: 22196728
    18. Loss of Tif1g in mouse HSCs favored the expansion of the granulo-monocytic progenitor compartment & induced the age-dependent appearance of a cell-autonomous myeloproliferative disorder resembling human CMML. PMID: 21537084
    19. Somatic hepatocyte-specific inactivation of TRIM24, TRIM28, or TRIM33 all promote hepatocellular carcinoma in a cell-autonomous manner in mice. PMID: 21531907
    20. intracellular negative control of Smad function by ectodermin/Tif1gamma is a crucial element in the cellular response to TGFbeta signals in mammalian tissues PMID: 20573697
    21. transcriptional intermediary factor has a major role in the differentiation of hematopoietic cells PMID: 15314655
    22. Generation of mice with conditional allele for Trim33 is reported. PMID: 18543301
    23. In a mouse model, study showed that Tif1gamma was dispensable for normal pancreatic development but cooperated with Kras activation to induce pancreatic tumors reminiscent of human Intraductal Papillary Mucinous Neoplasms (IPMNs). PMID: 19629168

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  • 亚细胞定位：
    Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Ubiquitous with high level in testis.
  • 数据库链接：

    KEGG: mmu:94093

    STRING: 10090.ENSMUSP00000029444

    UniGene: Mm.195036

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