Recombinant Mouse E3 ubiquitin-protein ligase RNF216 (Rnf216), partial

中文名称：

小鼠Rnf216重组蛋白
货号：

CSB-YP019876MO
规格：
来源：

Yeast
其他：

中文名称：

小鼠Rnf216重组蛋白
货号：

CSB-EP019876MO
规格：
来源：

E.coli
其他：

中文名称：

小鼠Rnf216重组蛋白
货号：

CSB-EP019876MO-B
规格：
来源：

E.coli
共轭：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名称：

小鼠Rnf216重组蛋白
货号：

CSB-BP019876MO
规格：
来源：

Baculovirus
其他：

中文名称：

小鼠Rnf216重组蛋白
货号：

CSB-MP019876MO
规格：
来源：

Mammalian cell
其他：

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纯度：

>85% (SDS-PAGE)
基因名：

Rnf216
Uniprot No.：

P58283
别名：

Rnf216; Triad3; Ubce7ip1; Uip83; Zin; E3 ubiquitin-protein ligase RNF216; EC 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1
种属：

Mus musculus (Mouse)
蛋白长度：

Partial
蛋白标签：

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
产品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

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功能：

Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis.
基因功能参考文献：
1. Low RNF216 expression is associated with obesity-induced inflammation. PMID: 28154178
2. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation. PMID: 27995769
3. identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases PMID: 25484083
亚细胞定位：

Cytoplasm.
数据库链接：

KEGG: mmu:108086

UniGene: Mm.381440

Recombinant Mouse E3 ubiquitin-protein ligase RNF216 (Rnf216), partial

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